Natural Lipid Management & Optimization of Cardiac and Vascular Health
THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION IS INTENDED FOR PHYSI-
CIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS.
THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARY SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT
INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. Lipotrienols RYR™ is a powerful combination of natural substances intended to favorably
modulate the blood lipid profile and optimize cardiac and vascular health, including high delta-
Serving Size 2 capsulesServings Per Container 30
fraction tocotrienols, organic red yeast rice extract (Monascus purpurea), and lycopene with added
Amount Per Serving % Daily Value Organic Red Yeast Rice (Monascus purpureus)
Red yeast rice is the product of yeast (Monascus purpureus ) grown on rice, containing several
compounds collectively known as monacolins, substances known to modulate blood lipids.1
Overall, studies suggest that RYR may reduce cardiovascular risk2-3 by virtue of its lipid modulat-
Other Ingredients: Microcrystalline cellulose,
ing1, anti-inflammatory4, antioxidant5, and antimicrobial properties, as well as its ability to lower
blood pressure and reduce proliferation of the arterial layer known as the intima, the area of thevessel where atherosclerotic lesions occur.6-8
The red yeast rice in Lipotrienols RYR™ is USDA certified organic and grown in the USA. Designs for Health takes great care to assay our red yeast rice to assure that there are undetectable levels of citrinin (< 1 ppm), as well as substantial levels of naturally-occurring monocolin compounds (4 mg per 2 capsule serving). Tocotrienols
Research by Bristol Myers Squibb, and others, has demonstrated that delta and gamma tocotrienols are the most effective tocotrienol fractions at modulating blood lipids, especially in the absence of tocopherols.9 Tocotrienols are often supplied from rice bran oil or palm oil. These contain between 30-50% tocopherols. Tocopherols greater than 20% decrease the effect of tocotrienols on modulating blood lipids. Annatto tocotrienols, used in Lipotrienols RYR™, are a unique makeup of 90% delta-tocotrienol and 10% gamma-tocotrienol with zero tocopherols. Research has clearly proven the ability of tocotrienols to modulate blood lipids.10 Tocotrienols decrease the conversion of farnesyl, a mevalonate derived intermediate, to farnesol, which usually goes on to make squalene and ultimately cholesterol. The increasing farnesol pool then signals the proteolytic degradation and downregulation of the HMG-CoA reductase enzyme. Tocotrienols also upregulate LDL receptors and LDL clearance and also inhibit the progression of carotid artery stenosis that may lead to stroke.9-10
Profound synergism has been demonstrated in the peer-reviewed literature regarding the concomitant use of both lovastatin andtocotrienols in favorably altering serum lipid profiles and reducing biomarkers of cardiovascular risk.11-12 For example, a 14%reduction in total cholesterol was seen when used alone vs. a 20% reduction when taken together.13 Since red yeast rice is alsoa HMG-CoA reductase inhibitor it is likely that similar synergistic effects between red yeast rice and tocotrienols would also beobserved.
Lycopene is a carotenoid present in human serum, liver, adrenal glands, lungs, prostate, colon, and skin at higher levels thanother carotenoids. Lycopene has been found to possess antioxidant and antiproliferative properties in animal and in vitro stud-ies. Numerous epidemiological investigations have correlated high intake of lycopene-containing foods or high lycopene serum
levels with reduced incidence of cancer, cardiovascular disease, and macular degeneration.14-16 A group of researchers gave post-menopausal women either HRT (hormone replacement therapy) or 2 mg lycopene. Both gave similar significant reductions intotal cholesterol and LDL and an increase in HDL.17 Women who do not wish to use HRT during menopause can receive thesame protection from coronary artery disease by consuming lycopene.
Lecithin (40% phoshatidylcholine) has been shown in research to enhance absorption of lycopene and likely aids absorption ofthe other fat-soluble compounds such as the tocotrienols.18
How to Take Lipotrienols RYR™
Dosage: As a dietary supplement, take two capsules with food, at night, since cholesterol synthesis is greatest while sleeping. Take a few hours away from an alpha-tocopherol, vitamin E, containing product such as a multivitamin.
Should Anything Else Be Taken with Lipotrienols RYR™?
Since Lipotrienols RYR™ affects the HMG-CoA-reductase enzyme, although more subtly than statin medications, it may mildly reduce endogenous production of coenzyme Q10. Therefore, it is advised that those taking Lipotrienols RYR™ also take supplemental CoQ10, such as Q•Avail or Q•Avail Nano by Designs for Health. For even more aggressive lipid control consider DFH Cholesterol Support Packets. Who Should Not Take Lipotrienols RYR™
This product is not recommended for pregnant and lactating women. Cholesterol levels naturally increase during pregnancy tosupport the necessary increase in hormone production.
1. Patrick, L. and Uzick, M. Cardiovascular disease: C-reactive protein and the inflammatory disease paradigm: HMG-CoA reductase inhibitors, alpha-tocopherol, red
yeast rice, and olive oil polyphenols. A review of the literature. Altern.Med Rev. 2001;6(3):248-271.
2. Zhao, S. P., Lu, Z. L., Du, B. M., Chen, Z., Wu, Y. F., Yu, X. H., Zhao, Y. C., Liu, L., Ye, H. J., and Wu, Z. H. Xuezhikang, an extract of cholestin, reduces
cardiovascular events in type 2 diabetes patients with coronary heart disease: subgroup analysis of patients with type 2 diabetes from China coronary secondary prevention study (CCSPS). J Cardiovasc.Pharmacol 2007;49(2):81-84.
3. Journoud, M. and Jones, P. J. Red yeast rice: a new hypolipidemic drug. Life Sci. 4-16-2004;74(22):2675-2683. 4. Liu, L., Zhao, S. P., Cheng, Y. C., and Li, Y. L. Xuezhikang (red yeast rice) decreases serum lipoprotein(a) and C-reactive protein concentrations in patients with
coronary heart disease. Clin Chem. 2003;49(8):1347-1352.
5. Martinkova, L., Patakova-Juzlova, P., Krent, et al. Biological activities of oligoketide pigments of Monascus purpureus. Food Addit.Contam 1999;16(1):15-24. 6. Hsieh, P. S. and Tai, Y. H. Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats. J Agric.Food Chem.
7. Kohama, Y., Matsumoto, S., Mimura, T., Tanabe, N., Inada, A., and Nakanishi, T. Isolation and identification of hypotensive principles in red-mold rice. Chem Pharm
8. Qi, G., Dingy, Z., Li, L., and Anle, Z. Effects of xuezhikang on neointimal proliferation and C-myc gene expression after angioplasty in rabbits. Chinese Journal of
9. Tomeo AC, Geller M, Watkins TR, Gapor A, and Bierenbaum ML. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids 1995
10. Qureshi, Qureshi, Wright et al. 1991. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols. J. Am. Clin. Nut 53:1021S-1026S. 11. Qureshi AA, Peterson DM. The combined effects of novel tocotrienols and lovastatin on lipid metabolism in chickens. Atherosclerosis 2001;156(39-47)12. McAnally JA, Gupta J, Sodhani S, et al. Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo. Exp Biol Med 2007;232:523-531. 13. Qureshi AA, et al. Synergistic effect of tocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans. J. Nutr
14. Knekt P, Reunanen A, Jarvinen R, et al. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 1994;139(12):1180-
15. Morris DL, Kritchevsky SB, Davis CE. Serum carotenoids and coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up
16. Fuhrman B, Elis A, Aviram M. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL
receptor activity in macrophages. Biochem Biophys Res Commun 1997;233(3):658-662.
17. Misra R. et al. LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial.
J. Obstet Gynaecol Res. 2006 Jun;32(3):299-304.
18. Megumi Nishimukai and Hiroshi Hara. Enteral Administration of Soybean Phosphatidylcholine Enhances the Lymphatic Absorption of Lycopene. J. Nutr. 134:1862-
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29. AUGUST 1997 - Königlicher Erlass über die Herstellung von und den Handel mit Lebensmitteln, die Pflanzen oder Pflanzenpräparate enthalten oder daraus bestehen (offizielle deutsche Übersetzung: Belgisches Staatsblatt vom 27. Oktober 1999) Die vorliegende inoffizielle koordinierte Fassung enthält die Abänderungen, die vorgenommenworden sind durch: - den Ministeriellen Erlass vom 6.
It’s Changing Faster than Moore’s Law, but Is U.S. Policy Keeping Pace?In 1990, the U.S. launched an audacious scientific endeavor with the potential to changethe practice of medicine when the National Institutes of Health and the Department ofEnergy joined with the international community in a quest to sequence all 3 billion let-ters, or base pairs, in the human genome, which is the complete