Prof. arafat

ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ



Nationality : Jordanian
Marital Status: Married with three children
Petra University, Faculty of Pharmacy and Medical Sciences
Amman – Jordan.
P.O.Box (960435)
Telephone No. 00962-6-5347671
Fax No: 00962-6-5349079
e-mail : [email protected]

Professor of Pharmaceutical Chemistry,
Dean of the Faculty of Pharmacy and Medical Sciences
University of Petra, Amman Jordan since 1992 till now.


1. Ph.D in Pharmaceutical Chemistry, 1980, School of Pharmacy U.W.I.S.T, 2. M.Sc in Pharmaceutical Analysis, 1977, School of Pharmacy U.W.I.S.T, 3. B.Sc Pharmacy, June, 1974, School of Pharmacy, Baghdad University, Iraq. ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

**Dean, Faculty of Pharmacy and Medical Technology, University of Petra
Amman Jordan, 1992 till now.
** Dean, Faculty of Pharmacy Jordan University 1991-1992
**Principal Investigator of Bioequivalence studies since 1983 till now.
**Consultant and Reviewer for the Ministry of Health in Jordan in subjects related
to Bioequivalence and Bioavailability studies.
**Chairman of Pharmaceutical Chemistry Department, School of Pharmacy,
Jordan University, Amman Jordan 1988-1989.
**Assistant Dean, School of Pharmacy, Jordan University, Amman Jordan, 1986 –
**Associate Professor, 1990, School of Pharmacy, Jordan University Amman
**Assistant Professor, 1983, School of Pharmacy, Jordan University, Amman
**January, 1982 - October 1983, Senior Researcher, ACDIMA, Amman, Jordan
**January, 1980 - January 1982, Head of the Quality Control Department, Kuwait
Pharmaceutical Plant, Kuwait
**June, 1974 -June 1975 Pharmacist in-charge, Al-Hanan Pharmacy Kuwait.

During the period of 1983 till now, I have been teaching the following courses:
**Organic Pharmaceutical Chemistry
**Analytical Chemistry
**Medicinal Chemistry
**Instrumental Analysis
**Advanced Instrumental Analysis
ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ


1. Factors Influencing Polymorphic Transition of Hyoscine N-Butyl Bromide.
T.Arafat, M.Saleh and A.Badwan.
Drug Development and Industrial Pharmacy. 14(15-17), 2127- 2142 (1988).

2. Physicochemical Study of Terfenadine Glassy State.
M.Sheikh Salem, M.Hassan, H.Alkaysi, T.Arafat, A.Abumalooh
and A.Badwan.
International Conference of Pharmaceutical Technology. Paris.
3.Levelling off the Effect of particle Size on Dissolution in Spironolactone
A.Badwan, Nabulsi, M. Saleh, and T.Arafat.
International Conference on Pharmaceutical Technology. Paris.
4. Bromhexine Determination by Diazotization Using Potentiometric Titration.
Analytical Letter, Vol. 2, 1990.
5. Physicochemical Properties of Ethinyloestradiol E.Sallam, N. Salman, T. Arafat, and R. Zaru.
6th Pharmaceutical Technology Conference, Paris. June 1992
6. Dissolution Characteristics of Interactive Powder Mixtures.
E.Sallam, H.Ibrahim, M.Takieddinin, T.Baghal, M.Saket, R.Awad
and T.Arafat.
8th Pharmaceutical Technology Conference, Monte Carlo. June 1994
7. Studies Relating to the Content Uniformity of Suppositories.
E.Sallam, H.Ibrahim, M.Takieddin M.Saket, R.Awad, T.Arafat
and M. Othman.
Drug Development and Industrial Pharmacy, 15(14-16), 2653-2673, 1989.
ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

8. A Bioequivalence Study of two Products of Ranitidine Tablets.
M.Saket, T.Arafat, R.Awad, H.Ibrahim, M. Saleh, E.Sallam,
S.Zmeili and M.Gharaibeh.
Current Therapeutic Research, Vol. 46, 5, 924-931, 1989.
9. A bioequivalence Study of two Products of Dipyridamole Tablets.
T.Arafat, M.Saket, R.Awad, H.Ibrahim, M.Saleh, M.gharaibeh,
E.Sallam and M.Shber.
International Journal of Clinical Pharmacology Therapy and Toxicology. vol.
27, 11, 564-567, 1989.
10. Analysis of Ranitidine in Plasma using High Pressure Liquid
T.Arafat, M.Saket, R.Awad, M.Saleh, E.Sallam and M.Gharaiabeh
Alexandria Journal of Pharmaceutical Science. 1990.
11. High Performance Liquid Chromatography (HPLC) Determination of
Nifedipine in Human Serum.
T.Arafat, Y.Al-Qussuis, H.Mouti, S.Zmieli, S.Judeh and O.Shaheen. Dirasat,Vol. 17, Number 3, 1990.
12. Terfenadine
A.Badwan, H.Alkaysi, L. Owis, M.Salem and T.Arafat.
"Analytical Profile of Drug Substances" .Vol. 19, 627-661, 1990.
13. Some Formulation Aspects of Terfenadine Solid Dispersion.
A.Badwan, A.Abumallh, L.Owis, M.Salem, H.Alkaysi and T.Arafat
Eur. J. Pharm. Biopharm, 37(3), 166-170, 1991.
ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

14. Pharmacokinetics and Pharmacodynamics of Two Commercial Oral Nifedipine
O.Shaheen, S.Zmeili, Y.Al-Qussuois, T.Arafat and H.Mouti.
International. J. of Clinical Pharmacology, Therapy and Toxocology. Vol.29
(9), 337-341, 1991.
15. A Bioequivalence Study of Two Products of Furosemide Tablets.
R.Awad, T.Arafat, M.Saket, M.Saleh, M.Gharaibeh, S.Zmeili,
E.Sallam, M.Shubair and S.Qobrosi
International J. of Clinical Pharmacology, Therapy and Toxocology.Vol.
30 (1), 18-23, 1992.
16. Tenoxicam Polymorphic Modifications
L.Nabulsi, L.Owais, T.Arafat and A.Badwan.
6th International Conference on Pharmaceutical Technology, Paris, June, 1992.
17. Pharmacokinetics and Pharmacodynamics of Two Oral Formulations of
Metformin Hydrochloride.
T.Arafat, A.Kaddoumi, M.Shami and M.Yassin.
Advances In Therapy, Vol. 11, No.1, 21-33, 1994.
18. A Bioequivalence Study of Two Brands Of Captopril Tablets.
T.Arafat, A.Kaddoumi, N.Al-Muhtasib, M.Shami, M.Yassin and
A.Jehanli. Advances In Therapy, Vol. 11, No .6, 320-330, 1994.
19. A Liquid Chromatographic Method For The Determination of Norfloxacin in
Alex. J. Pharma. Sci., Vol. 9(1), February, 1995.
20. Determination of Cisapride in Biological Samples.
T.Arafat, M.Shami, A.Kaddoumi, A.Badwan and M.Yassin.
Alex. J. Pharma. Sci., Vol., 9(1), February, 1995.
ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

21. Determination of Terfenadine in Commercial Dosage Forms By
Spectrofluorimetry and High Performance Liquid Chromatography
T.Arafat and A.Kaddoumi.
Alex. J. of Pharma. Sci. Vol., 9 (2), 113 , June.1995.
22.Determination of Captopril in Human Blood by an Enzyme - Linked
Immunosorbent Assay.
A. Jehanli, T. Arafat and M. Al-Shami
J.Pharma. Pharmacology, Vol. 48, (914-917), 1996.
23. Ibubrofen Sustained - Release Dosage Forms.
M.Gharaiabeh, T.Arafat and E. Sallam.
Clinical Drug Investigation, Vol.11, (3), 174 - 183, 1996
24. Pharmacokinetic and Pharmacodynamic Profiles of Two Brands of Amlodipine
Determined by Enzyme Linked Immmunosorbent Assay
K.Matalka, T.Arafat, T.El-Thaher, K. Qawasmeh, S. Shebli, M.Hamad and
A. Badwan.
J.Pharm. Pharmacol. Commun. Vol. 6, 539- 544, 2000.

25. Enzyme Linked Immunosorbent Assay for Determination of Amlodipine in
K.Matalka, T.El-Thaher , Mohammad Saleem, T.Arafat, , Ahmed Jehanli
and A. Badwan.
J.of Clinical Laoratory Analysis. Vol. 15, 47- 53, 2001.
26. Assessment of a controlled release hydrophilic matrix formulation for
metoclopramide HCl.
Enas Hasan, Bassam Amro, Tawfiq Arafat, Adnan Badwan
European Journal of Pharmaceutics and Biopharmaceutics 55 (2003) 339-344.
ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ
27. Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enelapril and enalaprilat by two specific enzyme immunoassays T.Arafat, et al.
Journal of Clinical Pharmacy and Therapeutics, June {2005}, 30, 1 - 10
28. Effect of Steric bulk and stereochemistry on the rates of diketopiperazine
formation from N-aminoacyl-2,2-didimethylthiazolidine-4-carboxamidee
(dipeptideamides) – a model for a new prodrug linker system.
Ghadeer A.R. Suaifan , Mary F. Mahon, Tawfiq Arafat, and Michael D.
Tetrahedron 62, (2006) 11245- 11266.
29. A trend of low serum Vit. B12 in Jordanian adults from two ethnic groups in
Nancy Hakooz, Rana Abu- Dahab, Tawfiq Arafat and Mohammed Hamad.
Jordan Medical Journal, Vol; 40, no: 2 page 80-87 , 2006.
30. Validated liquid chromatographic–ultraviolet method for the quantitation of
tadalafil in human plasma using liquid–liquid extraction.
Ashok K. Shakya a,∗, Ahmed N.A. Abu-awwad b, Tawfiq A. Arafat b,
Munther Melhim.
J. of Chromatography and biomedical Application
accepted 29 January 2007

31. Synthetic approach to peptides containing the L-Gln-L Val-D(s) Dmt Motif
Ghadeer A.R. Suaifan , Tawfiq Arafat, and Michael D. Threadgill Bio0rganic and Medicinal Chemistry, Volume 15, (2007), 3474 - 3488.

ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

32. Smoking behavior modulates pharmacokinetics of orally administered
A.M Yousef Ph.D, Tawfiq Arafat, Ph.D, N.R. Bulatova Md. Ph.D, and R.Al-
Zumyli, B.Sc
Journal of Clinical Pharmacy and Therapeutics, (2008) 33, 439- 449.
33. Simultaneous Determination of Triprolidine and Pseudoephedrine in Human
Plasma by Liquid Chromatography-ion trap mass spectrometry
Ashok K. Shakya*1, Tawfiq A. Arafat2¶, Ahmad N. Abu awwad2,Munther
Melhim2, Jafar Al-Ghani2 and Mahmoud J. Yacoub2
Journal of Chromatography B, 2009

34. Tamsulosin quantification in human plasma by high performance liquid
Chromatography coupled to electrospray tandem mass spectrometry
Ashok K. Shakya1, Nancy M. Hakooz, Tawfiq A. Arafat, Ahmed N.A. Abu-
awwad, Jafar AbdEl-Ghani and Munther Melhim
Acta Chromatographica Journal, volu.22, 2010, 99-116
35. Simple and rapid HPLC method for the determination of alfuzosin in human
Ashok K. Shakya1, Tawfiq A. Arafat, Ahmad Abuawaad, Hamza Al-Hroub,
Munther Melhim
Jordan Journal of Pharmaceutical Sciences, volume 3, 2010, 25-36

36. Genetic Analysis of Thiopurine Methyl Transferase Polymorphisim in
Jordanian Population
Nancy Hakooz, Tawfiq Arafat, Debbie Payne, William Ollier, Julie Andrews
and William Newman
Poster Presentation in Portugal

ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

Bioadhesive controlled metronidazole release matrix based on chitosan and
xanthan gum.
Eftaiha Ala'a F; Qinna Nidal; Rashid Iyad S; Al Remawi Mayyas M; Al Shami
Munther R; Arafat Tawfiq A; Badwan Adnan A
Marine drugs 2010;8(5):1716-30.

38. Enhancement of Oral Bioavailability of Insulin in Humans
Adnan Badwan, mayas Remawi, Amani Elsayed, Tawfiq Arafat, Munther
Melhim, Omar Abu Hijleh, and naser Idkaidek,
Neuroendocrinology letters, Volume 30 No,1 , 2009, 101 - 105
39. Effect of Licorice Drink on the Systemic Exposure of Verapamil in Rabbits
Ibraheem D.Al-Deeb, Tawfiq Arafat and Yacoub M. Irshid
Drug Metabolism Letters,2010, 4, 173-179
40. Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans Nasir Idkaidek,Ph.D.* , Tawfiq Arafat, Ph.D.
Accepted for Publication,in Journal of Clinical Pharmacology, 2011 41. Influence of Genetic Variation in Enzyme CYP2C19 and the Effect on the Pharmacokinetic Profile of Lansoprazole, Screening the Allele frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 in the Jordanian Population. Nancy Hakooz. Imad Zallom and Tawfiq Arafat
Oral Presentation in Kuwait, 2011

42. Effect of Mint Drink on metabolism of Nicotine as measured by Nicotine to Cotinine Ratio in Urine of Jordanian Smoking Volunteers Abdulrahman Ghazi, Abdulazim Salhab, Tawfiq Arafat, and Yacoub irshaid
Nicotine and Tobaco Research, 2011, (1-7). ﺍﺭـــــﺘﺒﻝﺍ ﺔـــﻌﻤﺎﺠ
(ﺓﺩﻤﺘﻌﻤ ﺔﺼﺎﺨ ﺔﻌﻤﺎﺠ )
Faculty of Pharmacy &Medical Sciences. ﺔﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍﻭ ﺔﻝﺩﻴﺼﻝﺍ ﺔﻴﻠﻜ

43. The Effect of Ethyl Acetate Extracts of Pomelo Mix on Systemic Exposure of
Verapamil in Rabbits.
Suad Aqel, Yacoub Irshaid, Munir Gharaibeh and Tawfiq Arafat
Drug Metabolism letters, 2011, 5, 92- 98

Genetic polymorphism of CYP2C19 in a Jordanian population:
influence of allele frequencies of CYP2C19*1 and CYP2C19*2
on the pharmacokinetic profile of lansoprazole Imad Zalloum • Nancy Hakooz • Tawfiq Arafat
Mol. Biol Rep, July 2011,
Plasma concentrations of 25-hydroxyvitamin D among Jordanians:
Effect of biological and habitual factors on vitamin D status
Eyad M Mallah1*, Mohammad F Hamad2, Mays A ElManaseer3, Nidal
Qinna2, Nasir M Idkaidek3, Tawfiq A Arafat1and Khalid Z Matalka2 BMC Clinical Pathology 2011, 11:8
Metformin IR versus XR Pharmacokinetics in Humans
Nasir Idkaidek, Tawfiq Arafat, Munther Melhim , Jaafar Alawneh and Nancy
Journal of Bioequivalence & Bioavailability (accepted)

UDP-glucoronosyltransferase 1A4(UGTIA4)polymorphisms in a Jordanian
Nancy Hakooz, Sameh Alzubiedi, Al-Motassem Yousef, Tawfiq Arafat,
Rana Dajani, Nidaa Ababneh, Said Ismail
Mol. Bioi Rep. 25, February, 2012.


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