Journal homepage: www.jakraya.com/journal/vri Efficacy of Ivermectin – Clorsulon combination against mixed helminthic infection in goat – a case report Rajeev Ranjan Kumar1* and Stuti Vatsya2 Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar-263145 (Uttarakhand), India. Abstract
A combination of Ivermectin (at 0.2 mg/kg body weight S/C) and Clorsulon (at 2 mg/kg body weight S/C) was tested against mixed infection of gastro-intestinal nematodosis, fasciolosis and amphistomosis in goat. The results of the present study revealed that the anthelmintic was effective in controlling gastrointestinal nematodosis and fasciolosis only. Key words: Ivermectin, clorsulon, fasciolosis, gastro-intestinal
fasciolosis and amphistomosis are the common respectively. The eggs were identified as per their parasitic diseases of ruminants including goats morphology described by Soulsby (1982). The throughout the country. These diseases are also widely distributed in goats of Uttarakhand which coproculture and the larvae were harvested and hamper livestock production in terms of poor used for larval identification as per the key of growth rate, reduction in carcass quality and also make them susceptible to other infectious diseases. Several drugs have been used to control theses Diagnosis
diseases under field conditions. Therefore, the aim of the present study was to evaluate the sample, animal was found positive for Fasciola efficacy of Ivermectin plus Clorsulon against gigantica (EPG-90), amphistome (EPG-20) and natural infection with gastrointestinal nematodes, mixed infection of strongyles (EPG-4900). The Fasciola gigantica and amphistome in a goat. revealed that the animal harbored mixed infections Case History
aged between 2-3 years with weight about 30kg as presented with the history of profuse diarrhoea, Treatment
weakness, loss of appetite, anaemia, oedema of sub-mandibular region (bottle jaw), pale visible anthelmintic consisting of Ivermectin at 0.2 mg/kg mucous membrane and inability to rise on feet. body wt S/C plus Clorsulon at 2 mg/kg body wt S/C (Neomec SX, Intas Pharmaceuticals Ltd) and Clinical Examination
liver extract with multivitamins (Belamyl at 0.5ml I/M daily for 5 days) to compensate the hepatic goat was collected directly from rectum. The egg damage, loss of feeding and faster recovery of the per gram (EPG) of faeces was recorded on 0 day before treatment and on 3 and 7 days post treatment using sedimentation method (Soulsby, Results and Discussion
1982) and modified Mc Master Technique (MAFF, Veterinary Research International | July-September, 2013 | Vol 1 | Issue 1 | Pages 31-32 2013 Jakraya Publications (P) Ltd Kumar et al…. Ivermectin–Clorsulon combination against mixed helminthic infection in goat and Clorsulon showed hundred percent reduction % in faecal egg counts in Jamunapari goats in the EPG of Fasciola spp. and strongyles after 3 infected with G.I. nematode following treatment days post treatment (DPT) and the same was with Ivermectin on day 14 DPT. Flukicide activity observed on 7 DPT, but the EPG of amphistome of Clorsulon against mature Fasciola hepatica in remained the same. Improvement of the animal cattle has been also reported by Velarde et al. was observed 3 DPT and all the clinical signs (2001). Islam (2013) has also reported higher completely disappeared 5 DPT. The present efficacy of Ivermectin plus Clorsulon against findings indicates that the tested drug was Fasciola spp. and strongyles in cattle. Conclusion
reduction in EPG of Fasciola spp. and strongyles occured mainly due to the anthelmintic activity of suggested that the combined formulation of Clorsulon and Ivermectin, respectively. The Ivermectin and Clorsulon is highly effective and efficacy of Ivermectin against strongyles in goats may be used in controlling concurrent infection of has also been observed by Kumar et al. (2008). G.I. nematodosis and fasciolosis in small Godara et al. (2011) recorded a reduction of 98.11 References
Godara R, Sharma RL and Sodhi SS (2011). Efficacy of MAFF (1971). Manual of Veterinary Parasitological fenbendazole, levamisole and ivermectin against Laboratory Techniques. HMSO, London, Pp. 5- gastrointestinal nematodes in Jamunapari goats. Journal of Parasitic Diseases, 35(2): 219–221. Soulsby EJL (1965). Biology of Parasites. Academic Islam A (2013). Comparative efficacy of ivermectin plus clorsulon and nitroxynil against naturally Soulsby EJL (1982). Helminths, Arthropods and infected cattle. Eurasian Journal of Veterinary Protozoa of Domesticated Animals. 7th edn. ELBS Kumar RR, Yadav CL, Vatsya S and Bhardwaj V Velarde FI, Montenegro YV, Fuentes RN and Albarran (2008). Use of different anthelmintics for AS (2001). Efficacy of combined therapy against gastrointestinal nematodosis in goat flock under gastrointestinal nematodes and Fasciola hepatica. field conditions. Indian Journal of Animal Veterinary Parasitology, 99: 199-204. Production and Management, 24: 61-63. Veterinary Research International | July-September, 2013 | Vol 1 | Issue 1 | Pages 31-32 2013 Jakraya Publications (P) Ltd

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