IN RE: Seroquel Products Liability

Case No. 6:06-md-1769-Orl-22DAB
This cause came on for consideration after hearing on the following motion filed herein: PLAINTIFFS’ MOTION FOR DISCOVERY SANCTIONS
(Doc. No. 256)

July 3, 2007
THEREON it is ORDERED that the motion is GRANTED in part.
In this multidistrict litigation, Plaintiffs have sued Defendants for claims arising for alleged injuries from ingesting AstraZeneca’s Seroquel, an atypical anti-psychotic medication that allegedly can cause diabetes and related disorders. Doc. No. 1. Plaintiffs have moved for sanctions based on AstraZeneca’s “failure to timely comply with numerous discovery obligations since the inception of this litigation” based on four categories of conduct. Doc. No. 256 at 1. Plaintiffs base their Motion for Sanctions, first, on AZ’s failure to produce, in a readable format, key elements of the IND/NDA in November 2006 as ordered, not producing a key element until June 2007. Second, Plaintiffs contend that AZ failed to produce organizational charts by January 2006 as ordered and withheld the vast majority of them until May 14, 2007. Third, Plaintiffs argue AZ failed to identify all relevant databases which it was obligated to identify in January 2007, instead identifying only a fraction; to date, Plaintiffs have now identified fifty-nine relevant databases. Fourth, Plaintiffs’ strongest contention is that, although AZ was to produce electronic discovery from its self-chosen “custodians”–those employees most knowledgeable about Seroquel and its development–AZ waited until mid-May to begin production of the overwhelming majority of the documents and the documents actually produced have significant errors of omission and were not readable or searchable.
AZ contends that the Motion for Sanctions should be denied on procedural grounds because Plaintiffs have not successfully moved to compel and no sanctions are warranted because AZ has complied with the Court’s discovery orders. AZ argues that it has produced the entire IND/NDA to Plaintiffs; has produced organizational charts “early, often, and abundantly”; its custodial production was timely and appropriate; and it has not violated any orders to produce databases.
The Court finds that some of the conduct Plaintiffs have complained of is not sanctionable, however, AZ’s custodial production issues, and its uncooperative efforts to resolve technical issues, are a violation of e-discovery rules and principles. AZ’s failure to produce Item 12 of the CANDA in the IND/NDA was oversight or excusable neglect. AZ’s failure to produce organizational charts per CMO2 in a timely fashion was also the result of excusable neglect. However, AZ’s failure to cooperate in the production of the databases and its failure to timely and systematically produce electronic discovery associated with eighty AZ “custodians” in any manageable, searchable form are sanctionable conduct. The Court will reserve ruling on the appropriate sanctions pending further discovery and after Plaintiffs have the opportunity to offer evidence of the specific prejudice or added costs the sanctionable conduct has caused.
This multidistrict litigation was transferred to the Middle District of Florida by the Judicial Panel on Multidistrict Litigation on July 10, 2006. Doc. No. 1. On August 15, 2006, Judge Conway entered an order setting the first pretrial status and discovery conference for September 7, 2006.
Doc. No. 4. At that hearing there was a substantial discussion as to expectations for the progress of discovery. It was the Court’s expectation that the indisputably relevant material would be produced quickly and without difficulty, despite its volume. Counsel for AZ requested 60 days to complete electronic formatting of the NDA and IND. This extra time was deemed necessary to eliminate the possibility of being unable to meet the Court’s deadlines. Doc. No. 32 at 21. The Court’s reliance on experienced counsels’ ability to accomplish routine matters routinely and timely was in vain.
During the status conference held on November 20, 2006, the Court requested that the parties meet and confer “to submit either agreed proposals to cover document preservation, production protocol and resolution of this issue about formatting of things already produced by December 5, 2006.” Doc. No. 84 at 43. However, instead of submitting an agreed proposal for production protocol and formatting, the parties submitted competing proposals (Doc. No. 99 & 100), apparently without a good faith conference within the meaning of Local Rule 3.01(g). Three days before the December 8, 2006 status conference, the parties finally began discussions about electronic documents being produced with searchable load files, bates-stamped TIFF’s1 and various metadata fields. Doc. No. 100 at 1-2 (December 10, 2006). Following the status conferences before the Court on December 11–which the Court had to adjourn and carry over to December 12, 2006 because the parties had been unable to agree ahead of time–the parties proposed a Joint Motion to adopt two case 1TIFF (Tagged Image File Format) is one of the most widely used and supported graphic file formats for storing bit-mapped images, with many different compression formats and resolutions. A TIFF file is characterized by its “tif” file nameextension. The Sedona Conference Glossary for E-Discovery and Digital Information Management (The Sedona ConferenceWorking Group Series, May 2005 Version), available at http://www.thesedonaconference.org; cited in Williams v. Sprint/UnitedManagement Co., 230 F.R.D. 640, 643 (D. Kan. 2005).
The Joint Motion stated, “It is the stated policy of AZ counsel, and its client, that commensurate with the goals of these MDL cases to get to Plaintiffs’ counsel in a timely manner and in a format usable the necessary production documents that the opposing side will need to help them develop, evaluate, and understand their cases for purposes of ultimate prosecution and/or dismissal of cases. . . . It is submitted that [proposed] CMO 2 reflects the confluence of the competing interests of both parties, and reflects a workable, practical and judicially efficient methodology and system for the production of documents to the MDL Plaintiffs.” Doc. No. 110 at 4 (emphasis added). On its face, the proposal did that. Unfortunately, AZ has not lived up to producing discovery in a timely The proposed CMO 2 submitted by the parties set forth deadlines for AstraZeneca’s production of organizational charts for its corporate structure, the Seroquel team, and the drug safety team for the past ten years; listings of 80 (eighty) custodians from whom it is collecting documents; listing of databases concerning document production and preservation; timing for interviews of knowledgeable AstraZeneca IT persons, and the parties’ agreed format of the production of custodial files. Doc. No. 110-3. As the Court commented at the time, “The failure of the Defendant to investigate and understand its own records and documents and to prepare them for production has not met the expectations of the Court as discussed at the September 2006 Conference.” Doc. No.
113. The Court also commented on its misgivings as to the “proposed CMO 2 regarding production and preservation of Defendant’s documents, [which] still seems unduly cumbersome. Nonetheless, if the parties are confident that their agreement will allow them to present issues to the Court for appropriate consideration and disposition without delays engendered by claims of non production of information, the proposal can be approved.” Doc. No. 113. On January 26, 2007, Judge Conway entered CMO 2 (Doc. No. 129) portions of which were adopted verbatim from the parties’ proposed CMO 2. That order set forth specific undertakings and obligations regarding provision of discovery without the need for separate requests under the rules of procedure. Matters included a schedule for production of organizational charts; identification of AZ’s first round of eight chosen witnesses, all of whose documents would be produced earliest; AZ’s identification of relevant databases (including informal interviews with AZ’s IT staff); the required format for electronic documents (including required metadata fields); and deduplication of On April 26, 2007, Plaintiffs filed their Motion to Compel Defendants to Provide Complete Certified Production of the First Eight Custodial Files and All Other Custodial Files Produced to Date; Suspending the Custodial Production Method upon Completion of the Production of the Outstanding Custodial Files Produced to Date; and Immediately Permitting Plaintiffs to Proceed by a Notice to Produce Method of Discovery. Doc. No. 198. The Court denied the Motion to Compel without prejudice to allow the parties time to confer “in good faith and in extenso” on the issues described in the Motion to Compel; the Court also set an evidentiary hearing on the matters raised in the Motion for June 13, 2007, alerting the parties: ANY PARTY WHOSE CONDUCT NECESSITATES THE EVIDENTIARY
Doc. No. 210 (capitals and bold in the original). On June 8, 2007, the evidentiary hearing was canceled based on the parties’ Joint Statement of Resolved Issues and Notice that a Hearing is Not Required (Doc. No. 221) filed on June 7, 2007.
At that time, Plaintiffs accepted the representations made by AZ that corrections would be made to the problems Plaintiffs identified in the Motion to Compel, e.g., load files, metadata, bates numbering, page breaks, excel spreadsheets, and blank documents; the CANDA would also be produced; and the parties would continue to confer on the database production. Doc. No. 221.
However, less than one month later, on July 3, 2007, Plaintiffs filed their Motion for Sanctions (Doc. No. 256), one business day before the July 5, 2007 Status Conference. Following the July 5 status conference, the Court set an evidentiary hearing on the matter for July 26, 2007.
Doc. Nos. 263, 264. The Motion for Sanctions came on for hearing in this Court on July 26, 2007.
Standards for Electronic Discovery in Complex Litigation
As businesses increasingly rely on electronic record keeping, the number of potential discoverable documents has skyrocketed and so also has the potential for discovery abuse. Of even more consequence in this complex litigation is the fact that it involves development of a drug that spent many years in development by an international corporation and has been distributed worldwide, with the number of Plaintiffs in this multi-district litigation exceeding 6,500. The Manual for Complex Litigation (Fourth Edition) provides the following guidance for dealing with Computerized data have become commonplace in litigation. The sheer volume ofsuch data, when compared with conventional paper documentation, can bestaggering. . . . One gigabyte is the equivalent of 500,000 type-written pages. Largecorporate computer networks create backup data measured in terabytes, or 1,000,000megabytes; each terabyte represents the equivalent of 500 billion [sic] typewrittenpages of plain text.
Digital or electronic information can be stored in any of the following: mainframecomputers, network servers, personal computers, hand-held devices, automobiles, orhousehold appliances; or it can be accessible via the Internet, from private networks,or from third parties. Any discovery plan must address issues relating to suchinformation, including the search for it and its location, retrieval, form of production,inspection, preservation, and use at trial. For the most part, such data will reflect information generated and maintained in theordinary course of business. As such, discovery of relevant and nonprivileged datais routine and within the commonly understood scope of Rule 26 and 34. Other dataare generated and stored as a byproduct of the various information technologiescommonly employed by parties in the ordinary course of business, but not routinelyretrieved and used for business purposes. Such data include the following: Metadata, or “information about information.” This includes theinformation embedded in a routine computer file reflecting the file creationdate, when it was last accessed or edited, by whom, and sometimes previousversions or editorial changes. This information is not apparent on a screenor in a normal printout of the file, and it is often generated and maintainedwithout the knowledge of the file user. . . .
The judge should encourage the parties to discuss the scope of proposed computer-based discovery early in the case, particularly any discovery of data beyond thatavailable to the responding parties in the ordinary course of business. The requestingparties should identify the information they require as narrowly and precisely aspossible, and the responding parties should be forthcoming and explicit in identifyingwhat data are available from what sources, to allow formulation of a realisticcomputer-based discovery plan. Rule 26(b)(2)(iii) allows the court to limit or modifythe extent of otherwise allowable discovery if the burdens outweigh the likely benefit– the rule should be used to discourage costly, speculative, duplicative, or undulyburdensome discovery of computer data and systems. . . .
There are several reasons to encourage parties to produce and exchange data inelectronic form. . . – production of computer data on disks, CD-ROMS, or by file transferssignificantly reduces the costs of copying, transport, storage, andmanagement – protocols may be established by the parties to facilitate thehandling of documents from initial production to use in depositions andpretrial procedures to presentation at trial;– computerized data are far more easily searched, located, and organized thanpaper data; and – computerized data may form the contents for a common documentdepository.
The goal is to maximize these potential advantages while minimizing the potentialproblems of incompatibility among various computer systems, programs, and data,and minimizing problems with intrusiveness, data integrity, and informationoverload. . . . The relatively inexpensive production of computer-readable images may suffice forthe vast majority of requested data. Dynamic data may need to be produced in native format, or in a modified format in which the integrity of the data can be maintainedwhile the data can be manipulated for analysis. If raw data are produced, appropriateapplications, file structures, manuals, and other tools necessary for the propertranslation and use of the data must be provided. Files (such as E-mail) for whichmetadata is essential to the understanding of the primary data should be identifiedand produced in an appropriate format. MANUAL FOR COMPLEX LITIGATION § 11.446, Discovery of Computerized Data (Fourth Ed. 2004) (emphasis added). Against the backdrop of the heightened demands for usability and searchability of the electronic discovery produced in a multi-district case, is the need for the parties to confer on the format of the production, keeping in mind that the responding party is best situated to evaluate the procedures, and the need to produce the information in a reasonably usable form to enable the receiving party to have the same ability to access, search, and display the information. Id. Particularly in complex litigation, there is a heightened need for the parties to confer about the format of the electronic discovery being produced. Pursuant to Federal Rule of Civil Procedure 26, the parties are expected to confer, not only on the nature and basis of their claims and defenses, but also to discuss “any issues relating to disclosure or discovery or electronically stored information, including the form or forms in which it should be produced.” FED. R. CIV. P. 26(f)(3).
Rule 26(f) was amended on December 1, 2006 to direct the parties to discuss discovery of electronically stored information during their discovery-planning conference. FED. R. CIV. P. 26(f) advisory committee notes. The Order adopting this amendment to Rule 26 provides that such amendments “shall take effect on December 1, 2006, and shall govern in all proceedings thereafter commenced and, insofar as just and practicable, all proceedings then pending.” W.E. Aubuchon Co. v. Benefirst, LLC, __ F.R.D. __, 2007 WL 1765610, *3 (D. Mass. Feb. 6, 2007). According to Rule It may be important for the parties to discuss their systems, and accordinglyimportant for counsel to become familiar with those systems before the conference.
With that information, the parties can develop a discovery plan that takes into account the capabilities of their computer systems. In appropriate casesidentification of, and early discovery from, individuals with special knowledge of aparty’s computer systems may be helpful. The particular issues regarding electronically stored information that deserve attention during the discovery planning stage depend on the specifics of the givencase. See Manual for Complex Litigation (4th) § 40.25(2) (listing topics fordiscussion in a proposed order regarding meet-and-confer sessions). For example,the parties may specify the topics for such discovery and the time period for whichdiscovery will be sought. They may identify the various sources of such informationwithin a party’s control that should be searched for electronically stored information.
They may discuss whether the information is reasonably accessible to the party thathas it, including the burden or cost of retrieving and reviewing the information. SeeRule 26(b)(2)(B). Rule 26(f)(3) explicitly directs the parties to discuss the form orforms in which electronically stored information might be produced. The partiesmay be able to reach agreement on the forms of production, making discovery moreefficient. Rule 34(b) is amended to permit a requesting party to specify the form orforms in which it wants electronically stored information produced. If the requestingparty does not specify a form, Rule 34(b) directs the responding party to state theforms it intends to use in the production. Early discussion of the forms of productionmay facilitate the application of Rule 34(b) by allowing the parties to determine whatforms of production will meet both parties’ needs. Early identification of disputesover the forms of production may help avoid the expense and delay of searches orproductions using inappropriate forms. . . . Computer programs may retain draftlanguage, editorial comments, and other deleted matter (sometimes referred to as“embedded data” or “embedded edits”) in an electronic file but not make themapparent to the reader. Information describing the history, tracking, or managementof an electronic file (sometimes called “metadata”) is usually not apparent to thereader viewing a hard copy or a screen image. Whether this information should beproduced may be among the topics discussed in the Rule 26(f) conference. FED. R. CIV. P. 26(f)(3), advisory committee notes (emphasis added). A leading resource on dealing with electronic discovery is the Second Edition of the Sedona Principles, on which AZ relied at the July 26, 2007 hearing on the Motion for Sanctions. Principle 3 states, “Parties should confer early in discovery regarding the preservation and production of electronically stored information when these matters are at issue in the litigation and seek to agree on the scope of each party’s rights and responsibilities.” The Sedona Principles, Second Edition: Best Practices, Recommendations & Principles for Addressing Electronic Document Discovery (The Sedona Conference2 Working Group Series, 2007). Authority for Sanctions
Pursuant to Federal Rule of Civil Procedure 37, the Court may impose broad sanctions for discovery-related abuses. Federal Rule of Civil Procedure 37 governs a party’s failure to make a proper disclosure or cooperate in discovery. For purposes of Rule 37, an incomplete response is to be treated as a failure to respond. FED. R. CIV. P. 37(a)(3). Rule 37(b)(2) states that a court may grant sanctions against a party that “fails to obey an order to provide or permit discovery.” Sanctions may be granted against a party under Rule 37(b)(2) if there is noncompliance with a court order, notwithstanding a lack of wilfulness or bad faith, although such factors “are relevant . . . to the sanction to be imposed for the failure.” 8A Charles Alan Wright, Arthur R. Miller & Richard L.
Marcus, FEDERAL PRACTICE & PROCEDURE § 2283, at 608 (2d ed. 1994); see Melendez v. Ill. Bell Tel. Co., 79 F.3d 661, 671 (7th Cir.1996) (“Bad faith . is not required for a district court to sanction a party for discovery abuses. Sanctions are proper upon a finding of wilfulness, bad faith, or fault on the part of the noncomplying litigant.”); Alexander v. Fed. Bureau of Investigation, 186 F.R.D.
78, 88 (D. D.C. 1998) (“In making the determination of whether to impose sanctions, Rule 37(b)(2) does not require a showing of willfulness or bad faith as a prerequisite to the imposition of sanctions upon a party.” (citations omitted)). The district court has broad discretion to fashion appropriate sanctions for the violation of discovery orders. United States v. Certain Real Property Located at Route 1, 126 F.3d 1314, 1317 (11th Cir. 1997); see also Nat'l Hockey League v. Metro. Hockey Club, Inc., 427 U.S. 639, 642 (1976)); Friends of Animals, Inc. v. U.S. Surgical Corp., 131 F.3d 332, 334 2The Sedona Conference is a nonprofit legal policy research and educational organization which sponsors Working Groups on cutting-edge issues of law. The Working Group on Electronic Document Production is comprised of judges,attorneys, and technologists experienced in electronic discovery and document management matters.
(2d Cir. 1997) (“A district court has broad power to impose Rule 37(b) sanctions in response to III. CONTENTIONS AND ANALYSIS
Procedural Posture
AZ argues that the Motion for Sanctions should be denied on procedural grounds because there has been no motion to compel, no proper request for documents complained of, and no prejudice to Plaintiffs from the delay in the productions, relying on United States v. Certain Real Property Located at Route 1, 126 F.3d 1314, 1317 (11th Cir. 1997). However, in Certain Real Property the Eleventh Circuit reversed the harshest of sanctions, a default judgment, as a sanction for discovery abuse that had not been preceded by a court order or, notably, by a motion to compel.
Id. at 1317-18 (“[O]n its face, [Rule 37] does not require that a court formally issue an order compelling discovery before sanctions are authorized. . . . [T]he absence of either a motion to compel filed by the government or an order of the court compelling discovery, the violation of which might implicate Rule 37, rendered inappropriate the imposition of the types of sanctions levied here” [i.e., In circumstances such as those present in this case, there has been a motion to compel discovery directly on point as to AZ’s failings–giving adequate notice to AZ of Plaintiffs’ complaints – prior to the Court imposing sanctions. Doc. Nos. 198, 221. Plaintiffs filed their Motion to Compel listing many technical issues with regard to proper load files, metadata, bates numbering, page breaks, excel spreadsheets, blank documents, and CANDA, which the Court denied without prejudice to give the parties an opportunity to meet and confer (with technical people involved) before convening an evidentiary hearing on the discovery issues that Plaintiffs raised. In the Notice setting the hearing the Court warned in words written in bold and all capitals that sanctions would be imposed for obstreperous behavior. Doc. No. 210. In part, the Court allowed further conference between the parties to give counsel the opportunity to have their technical people participate in finding solutions. Following conferences between the parties, Plaintiffs filed a notice canceling the hearing based on the representations of AZ that the technical issues would be resolved by various means; otherwise, the evidentiary hearing would have gone forward with the distinct possibility of sanctions. When AZ failed to live up to its commitments made in the Joint Motion to resolve the technical issues, Plaintiffs filed their Motion for Sanctions raising some of the identical grounds, and the Court set these issues for hearing. AZ has had more than sufficient notice of the possibility of sanctions for its conduct in not producing the discovery in a usable format.
The Court may also impose sanctions based on its inherent power to manage its docket and its cases. In re Mroz, 65 F.3d 1567, 1575 (11th Cir. 1995) (quoting Chambers v. NASCO, Inc., 501 U.S. 32, 46 (1991)); Residential Funding Corp. v. Degeorge Fin. Corp., 306 F.3d 99, 106-07 (2d Cir. 2002) (court’s has the “inherent power to manage its own affairs” via sanctions). A finding of bad faith, however, is required to impose sanctions based on the Court’s inherent powers. In re Mroz, 65 F.3d at 1575. Notice that the conduct may warrant sanctions can come from the party seeking sanctions or from the court, and the accused must be given an opportunity to respond. Id. at Because the Court finds that Plaintiffs’ previous Motion to Compel, and the Court’s order setting the Evidentiary Hearing on the Motion gave AZ sufficient notice of the discovery conduct Plaintiffs were challenging and the possibility for sanctions if it was not resolved, the Court may sanction AZ for its conduct. AZ apparently relies on the fact that the Court had not granted Plaintiffs’ Motion to Compel and ordered AZ to produce certain documents. That argument is disingenuous. The sole reason the Motion to Compel was not revisited and the evidentiary hearing on its merits not held was because AZ agreed (in the Joint Statement of Resolved Issues - Doc. No.
221) that it would make corrections to the electronic discovery to make it accessible and searchable.
A party will not be permitted to gain an advantage by agreeing to cure the discovery violation, then fail to implement the cure, and hope to avoid a sanction by forestalling the sanctions ruling. AZ’s stipulation to resolve the discovery issues, under threat of sanctions for obstreperous behavior, does not preclude the Court from sanctioning it under Rule 37 under the circumstances of this multi- district case. See, e.g., In re Orthopedic Bone Screw Products Liability Litigation, No. MDL 1014, 1997 WL 805219 (E.D. Pa. 1997) (Bechtle, J.) (imposing Rule 37 sanctions on defendants in multi- district case for failure to produce certain discovery after the court entered a general pretrial order requiring compliance with discovery requests following plaintiffs’ previous motion to compel). In this case, the Court set an evidentiary hearing, threatened sanctions if the parties did not resolve the technical issues. AZ’s failure to meet its own commitments and its general chosen course of conduct regarding document production and resolution of difficulties warrants imposition of Rule 37 Particular Issues
1. IND/NDA--Plaintiffs contend that AZ failed to produce a key element of the IND/NDA
in November 2006 as ordered, not producing it until June 2007, and the materials produced were not in usable form. At the September 7, 2006 hearing, AZ stated that the electronic formatting of the IND/DNA had begun. Doc. No. 32 at 17-21. The Court allowed AZ until November 7, 2006 to produce it even though, as the Court pointed out, much of the material had been produced to the FDA in electronic format and should have been prepared for production earlier. Plaintiffs contend they had to spend “nearly two months of work” to make it suitable for substantive review and the production omitted the CANDA safety database – which was not produced until June 8, 2007.
Plaintiff’s expert and fact witness, Jonathan Jaffe3, testified that on November 15, 2007, Plaintiffs realized the IND/NDA production was not searchable for several reasons: no metadata was retrieved; there were multi-page TIFF images, some of which consisted of more than 20,000 pages; there was nothing showing bates numbering; 8% of the entire production was in one lengthy document which could only be opened with a very powerful work station; and there were no load files; thus the production was not in a usable or searchable format. At that point, on November 17, 2006, Mr. Jaffe sent to AZ’s counsel an email suggesting fixes to the IND/NDA. See Pl. Ex. 16.01.
As of nine months later, or the date of the July 26, 2007 hearing, AZ had not fixed problems according to Mr. Jaffe, whose team attempted to fix problems themselves by splitting apart the documents and the redoing bates numbering. AZ had offered to do it for $26,000 over 6 weeks; it took Mr. Jaffe’s team more than a month with a few dedicated team members.
Mr. Jaffe further testified that in November to December 2006, Plaintiffs asked for electronic documents in native or near native format, with metadata, and extracted text and image files, that had page breaks in it. Mr. Jaffe, supported by several exhibits, described extensive efforts to resolve technical issues. See, e.g., Pl. Ex. 16.03 and 16.04. Mr. Jaffe made multiple requests to speak to technical people, but he was told there was no IT person with whom he could confer regarding the IT issues.4 In response to a query by the Court, Mr. Jaffe testified that he did not believe that he had had discussions about IT problems with AZ’s vendors because he believed that a vendor could have straightened a lot of the issues out and would have used the same template. There was no equivalent IT expert counterpart (like Mr. Jaffe) at AZ’s law firm with whom he could confer.
3Mr. Jaffe has experience with Weitz & Luxenburg working with electronic document productions. He holds a degree in economics and mathematics from Columbia University. He began IT work in 1995 in last year of high school and hasworked at Weitz & Luxenburg since that time. AZ did not challenge his designation as an expert.
4AZ’s refusal to allow contact between individuals with appropriate technical backgrounds as part of the effort to resolve technical issues is an inexplicable departure from the requirements of Rule 26, the Sedona Principles and this Court’sexpressed expectations.
AZ contends that it produced in November 2006 more than 450,000 pages of the IND/NDA, including any amendments and communications with the FDA, and until the April 12, 2007 status conference, Plaintiffs did not mention the omission of the CANDA, an electronic version of the NDA submitted to the FDA in addition to the paper NDA. AZ contends that the Seroquel CANDA contains the same information as the Seroquel NDA (produced in November 2006), with the exception of Item 12 (Case Report Forms), which the FDA did not require to be submitted in hard copy and was only submitted as part of CANDA. AZ explains that it did not produce Item 12 separately because it believed Item 12 to be duplicative of the NDA production already made.
Because Item 12 was preserved on DLT tapes in a format now obsolete, AZ had to find a vendor capable of converting the tapes; after they were converted, AZ produced Item 12. AZ’s fact witness, Mr. Dupre, testified that AZ produced CANDA Item 12 on June 8 or 11, 2007. The Court finds that AZ’s failure to produce Item 12 was not more than excusable neglect or inadvertent failure not to produce what it believed had already been produced to Plaintiffs.
However, the problems in formatting the IND/NDA, which Plaintiffs apparently have since resolved, especially the page break problems and the lack of metadata, no load files, and lack of search data, while cured by Plaintiffs’ efforts, bear on the discussion of AZ’s failures to make the custodial production usable or in reasonably accessible format (as addressed below).
2. Organizational Charts--Plaintiffs contend that AZ was ordered to produce
organizational charts under CMO2 by January 2006 and although approximately twenty pages of charts were produced, Plaintiffs received the majority of the rest of the organizational charts at the Rule 30(b)(6) deposition of Ann Booth-Barbarian on May 14, 2007. AZ also produced additional charts on June 25, 2007 with custodial productions. Doc. No. 289 at 5. Plaintiffs have since propounded formal requests for more organizational charts, as to which AZ has indicated it is still investigating. Plaintiffs contend that AZ’s failure to timely produce the organizational charts has delayed their ability to identify key witnesses for custodial production and deposition.
AZ contends it has complied with its discovery obligations of CMO 2 because Plaintiffs could request additional organizational charts beyond the initial production by AZ, plaintiffs have done so, and AZ has responded. AZ argues that it should not be penalized for production of additional organizational charts at corporate representatives’ Rule 30(b)(6) depositions, where Plaintiffs’ deposition notices were accompanied by document requests, and the charts were The Court finds no sanctions are warranted on this issue. CMO 2 required that, by January 15, 2007, AstraZeneca was to produce “available organizational charts reflecting its general corporate structure, the structure of the Seroquel team, and the structure of the drug safety team for the past ten years.” Doc. No. 129. Plaintiffs could also serve written requests for additional organizational charts. Id. There was virtually no specific testimony as to the content of the charts 3. Database Production--Plaintiffs argue AZ failed to identify all relevant databases by
January 5, 2007, which it was obligated to do pursuant to CMO 2; instead AZ identified only 15 databases. Doc. No. 256 Ex. J. However, to date, Plaintiffs have identified fifty-nine relevant databases through additional interviews, depositions, and meetings. Plaintiffs contend that AZ has produced no information whatsoever from any of these databases, and they are resisting producing databases without Requests for Production. Plaintiffs requested basic information about each database in order to assist with prioritization, formatting and production – information which, by its own admission, AZ refused to provide until July 2, 2007.
AZ responds that it should not be sanctioned because Plaintiffs have “not even served AZ with any discovery requests for wholesale production of the databases,” AZ has not violated an order to produce, and it only identified a small number of databases initially because they only had to identify those that correlated to the 14 discrete categories identified by Plaintiffs. Doc. No. 278 at 10. In addition, AZ has produced IT witnesses for informal interviews and four days of 30(b)(6) CMO 2 required that, by January 5, 2007, AstraZeneca provide Plaintiffs with a list of databases of the following type: 1) adverse event database; 2) sales call tracking database; 3) IMS database; 4) clinical communications database; 5) regulatory database; 6) regulatory contact databases; 7) clinical trial database; 8) medical literature database; 9) research report database; 10) documentum or similar databases (document management systems used by many pharmacy companies); 11) visitor speakers bureau and/or thought leader databases; 12) clinical payments database; 13) field force rosters; and 14) instant message, voicemail, discussion forum and prior website page databases, transcripts and recovery. Doc. No. 129. By January 25, 2007, AstraZeneca was required to allow Plaintiffs to conduct informal interviews, in person or by telephone, of a knowledgeable AstraZeneca-employed IT person or persons who can adequately address plaintiffs’ questions about said databases and how information can potentially be produced or extracted from them. Doc. No. 129. “If, after any such interview, Plaintiffs determine that the individual cannot adequately answer their questions or does not have the requisite knowledge about the database in question, plaintiffs shall identify the issues for which they seek additional information, and AstraZeneca shall promptly identify an IT employee with knowledge of such issues and present that person for interview.” Doc. No. 129. AZ’s identification of the databases would not be construed as an agreement to produce them5; the parties were to confer regarding the discoverability and feasibility of any request for production of a database, including the form and scope of any such production. Doc. No. 129.
Testimony from the only two witnesses6 presented who had any involvement in the discovery process (as well as the exhibits) establishes that, with respect to identification and production of relevant portions of databases, “what we have here is failure to communicate.” Worse, the posturing and petulance displayed by both sides on this issue shows a disturbing departure from the expected professionalism necessary to get this case ready for appropriate disposition. Identifying relevant records and working out technical methods for their production is a cooperative undertaking, not part of the adversarial give and take. This is not to say that the parties cannot have reasonable disputes regarding the scope of discovery. But such disputes should not entail endless wrangling about simply identifying what records exist and determining their format. This case includes a myriad of significant legal issues and complexities engendered by the number of plaintiffs. Dealing as effective advocates representing adverse interests on those matters is challenge enough. It is not appropriate to seek an advantage in the litigation by failing to cooperate in the identification of basic The parties’ mode of proceeding here has prevented the presentation of any genuine issues as to the proper scope of production of material from data bases. Both parties must bear some of the responsibility for the breakdown, but it is primarily AZ, as the creator and owner of the 5AZ argues that it is not obligated to give Plaintiffs access to its databases, following Eleventh Circuit precedent in In re Ford Motor Company, 345 F.3d 1315 (11th Cir. 2003). AZ also argued that, according to the deposition testimony of JonDowling, a senior manager in the information services section, the databases are not Seroquel specific. Doc. No. 297-60, Def.
Ex. 43 at 78-81. Mr. Dowling testified (on May 9, 2007) that it would take about six months to extract the data for a singledrug such as Seroquel from one database. Doc. No. 297-63, Def. Ex. 44 at 295-97. None of this bears, however, on AZ’sfailure to confer in good faith on the database production.
6AZ’s decision to offer only the testimony of a junior level attorney, only somewhat versed in technical issues and one who came late to the process is puzzling. AZ provided essentially no information as to how it organized its search forrelevant material, what steps it took to assure reasonable completeness and quality control. Its efforts at finding solutions totechnical problems are likewise unilluminated.
information, which has failed to make a sincere effort to facilitate an understanding of what records are kept and what their availability might be. The Court finds sanctions are warranted for AZ’s violation of the Court’s explicit order in CMO 2 that the Plaintiffs were to interview AZ’s IT employees and if, they still had questions after the interview, would identify the issues for which they still needed information, and AstraZeneca was to identify an IT employee with the relevant knowledge. Doc. No. 129. In addition, the parties were to confer regarding the discoverability and feasibility of any request for production of a database. Based on the testimony of Mr. Jaffe, Plaintiffs’ interviews of the AZ IT employees left questions about the databases unanswered because they were not clear or specific. Plaintiffs’ attempt to get further clarification through the chart was within the bounds of conferring further Based on the testimony of Mr. Dupre at the hearing, by its own admission, AZ stopped participating in the process to confer on the databases despite its explicit agreement to produce them and to cooperate in providing personnel familiar for Plaintiffs to interview to determine which ones to seek production of. Mr. Dupre also testified that AZ never intended to produce databases, it would only produce some subset of information; yet he emailed Plaintiffs’ counsel that AZ would work cooperatively with Plaintiffs on production of databases (Pl. Ex. 16.20). AZ’s failure to cooperate in identification leading to appropriate production of its relevant databases is conduct sanctionable under Rule 37. The relief to be awarded will be dealt with separately.
4. Custodial Production--AZ’s biggest failure has been what can properly be characterized
as “purposeful sluggishness” in the production from its self-chosen “custodians”–those employees most knowledgeable about Seroquel and its development. Plaintiffs contend AZ waited until mid- May 2007 to begin production of the overwhelming majority of the documents from these “custodians” and the documents produced have significant errors of omission and are not readable or searchable. Plaintiffs contend that the custodial production has a great deal of missing data, e.g., although AstraZeneca has a system to deliver voicemail, faxes, and video into Outlook inboxes, none has been produced; there are few emails from some custodians, and email boxes are missing from alternate email boxes. Plaintiffs also contend that many relevant emails and documents were not identified and produced because AZ performed an unreasonable key word search7. Plaintiffs allege that other relevant documents were omitted because the best available de-duplication method was not used; AZ missed deadlines and produced the electronic documents late; a significant portion of the production had blank pages; new load files were not searchable, in part because the date formats in the metadata were inconsistently loaded and email attachments not consistently associated or identified; authors were not identified as custodians for files; transposed metadata recipients/authors; and no page breaks were inserted in 3.75 million pages.
AZ responds that Plaintiffs have not met standard for imposing sanctions, which is bad faith.
AZ argues that Plaintiffs’ discovery issues have been a moving target, and that issues raised by Plaintiffs have been resolved or “in the process of being resolved” by July 20, 2007. AZ has produced “massive” amounts of discovery – 10 million pages8 – with few mistakes and by the June 30, 2007 deadline. AZ argues that Plaintiffs were aware that it was using search terms to limit the “custodians’” discovery to identify potentially responsive electronic documents, citing the Sedona Principles. AZ contends that it gave Plaintiffs a list of its 60 search terms in April 2007 and if Plaintiffs wanted AZ to use additional terms, Plaintiff could have simply asked for them. During 7Examples include omitting Seroquel’s generic name, acronyms for diabetes, hyperglycaemia spelled the British way; and endocrine. The search method apparently failed to include common misspellings or the singular forms of words and failedto make allowance for spaces or dashes.
8In argument, AZ has repeatedly relied on the sheer volume of documents produced as an accomplishment somehow justifying its shortcomings. In the context of this case, the Court is not impressed by the large number of relevant documents,especially since vast quantities were produced in a virtually unusable manner.
discussions just prior to the July 26 hearing, AZ offered to run additional search terms suggested by Plaintiffs, but they have been “stubbornly unresponsive.” Doc. No. 278 at 8. AZ contends that its production is not missing “a great deal of email” as alleged by Plaintiffs because it did not intentionally exclude emails (Doc. No. 278 at 9), but systematically collected electronic information on each custodian’s computer, including emails. AZ admits that it did not search proxies for the custodians, in part because, it claims, the principal would have a carbon copy of any substantive email, sent by the proxy. This supposition was not verified by any witness.
The record shows a number of specific failings9 in AZ’s chosen efforts to meet its discovery commitments. The key word search was plainly inadequate. Attachments, including non verbal files, were not provided. Relevant emails were omitted. AZ’s deduplication method remains mysterious. Production was tardy. AZ’s efforts in preventing and solving technical problems were woefully deficient. These shortcomings were adequately and persuasively described by Plaintiffs’ witnesses.10 AZ’s limited witness and arguments, to the extent they take issue with most of Plaintiffs’ contentions, lacked foundation and completeness and were frequently off point.
AZ purported to embrace the requirements of Rule 26 and the Sedona Principles. However, the reality was to the contrary. For example, while key word searching is a recognized method to winnow relevant documents from large repositories, use of this technique must be a cooperative and informed process. Rather than working with Plaintiffs from the outset to reach agreement on appropriate and comprehensive search terms and methods, AZ undertook the task in secret.
9The full scope and ultimate impact of these shortcomings was not made clear by the testimony and likely will be the 10AZ took great issue with the academic credentials of Plaintiffs’ expert, John Martin. Any puffery in Mr. Martin’s resume was tangential to the technical problems he identified in AZ’s production. The time and effort expended in investigatingand questioning Mr. Martin about his degree and speeches would have been better spent understanding and solving real issues.
The Court is satisfied that Mr. Martin possesses sufficient expertise in electronic document production to provide usefultestimony.
Common sense dictates that sampling and other quality assurance techniques must be employed to meet requirements of completeness. If AZ took such steps, it has not identified or validated them.
Many of the other technical problems identified by Mr. Martin and Mr. Jaffe likely could have been resolved far sooner and less expensively had AZ cooperated by fostering consultation between the technical staffs responsible for production. Instead, AZ shielded its third party technical contractor11 from all contact with Plaintiffs. This approach is antithetical to the Sedona Principles This is not to say that AZ completely ignored its responsibilities. Mr. Dupre and other representatives from his firm did participate in extended efforts to confer with Plaintiffs. However, the lateness and general ineffectuality of these efforts was demonstrated by Mr. Dupre’s concessions as to the limitations of his role.12 Mr. Dupre admitted on cross-examination that he had nothing to do with developing the key word search in this case and had never prepared any other key word search before; he did not know who was the architect of the key word search. Despite this lack of knowledge, he was confident that he knew how the emails were collected. Mr. Dupre also had no knowledge of how the 80 “custodians” were chosen. In response to a query from the Court, Mr.
Dupre could not identify with certainty who was responsible from AZ or its counsel or vendor for assuring document production had been sufficient to comply with the Local Rules and the Sedona Principles. In terms of the documentation about how the key word search was developed, Mr. Dupre testified that AZ used stock interview for “custodians”; but he was not privy to any sort of written protocol. He testified that there was no document production quality control or master plan with which he was familiar. He testified that the vendor never discussed the key word list with Plaintiff, 11Notably, AZ conceded that its vendor’s performance has been disappointing. The project manger was discharged 12Mr. Dupre testified that his firm was not hired until late February 2007 or maybe the very beginning of March, at which time, three-quarters of a million documents had already been produced and that vendors never participated in a meet and confer, although IT experts from lawyers attended The Court will not recite each of the technical problems described by the witnesses and the halting efforts to solve them. Suffice it for present purposes to observe that neither the method chosen by AZ nor the results it achieved in timely producing what was understood to be the great bulk of relevant material in a readily accessible form was satisfactory. The Court does not have confidence that AZ’s production of custodial files is complete, reliable or in proper technical format.
This lack of confidence extends to the solution AZ submitted to Plaintiffs on July 20 (six days prior AZ and its counsel had a responsibility at the outset of the litigation to “take affirmative steps to monitor compliance so that all sources of discoverable information are identified and searched.” As Judge Sheindlin explained regarding the party and counsel’s responsibilities in the much-cited Zubulake v. UBS Warburg LLC, 229 F.R.D. 422, 432 (S.D. N.Y. 2004): A party’s discovery obligations do not end with the implementation of a “litigationhold” - to the contrary, that’s only the beginning. Counsel must oversee compliancewith the litigation hold, monitoring the party’s efforts to retain and produce therelevant documents. Proper communication between a party and her lawyer willensure (1) that all relevant information (or at least all sources of relevant information)is discovered, (2) that relevant information is retained on a continuing basis; and (3)that relevant non-privileged material is produced to the opposing party. . . .
Once a “litigation hold” is in place, a party and her counsel must make certain thatall sources of potentially relevant information are identified and placed “on hold,”to the extent required in Zubulake IV, [220 F.R.D. at 218]. To do this, counsel mustbecome fully familiar with her client’s document retention policies, as well as theclient’s data retention architecture. This will invariably involve speaking withinformation technology personnel, who can explain system-wide backup proceduresand the actual (as opposed to theoretical) implementation of the firm’s recycling 13Plaintiffs were unable load this production; there was still no evidence of voice mails or faxes (other than two pages); there were no videos; no change tracking of documents; and they could not find documents by bates numbers. Although Mr.
Jaffe had had hundreds of conferences with AZ representatives since November 15, 2006, AZ never discussed the key wordsearch, and he only learned of the list AZ used in May 2007 policy. It will also involve communicating with the “key players” in the litigation,in order to understand how they stored information. In this case, for example, some[of defendant’s] employees created separate computer files pertaining to [theplaintiff], while others printed out relevant e-mails and retained them in hard copyonly. Unless counsel interviews each employee, it is impossible to determinewhether all potential sources of information have been inspected. A briefconversation with counsel, for example, might have revealed that Tong maintained“archive” copies of e-mails concerning [the plaintiff], and that “archive” meant aseparate on-line computer file, not a backup tape. Had that conversation taken place,[the plaintiff] might have had relevant e-mails from that file two years ago.
To the extent that it may not be feasible for counsel to speak with every key player,given the size of a company or the scope of the lawsuit, counsel must be morecreative. It may be possible to run a system-wide keyword search; counsel could thenpreserve a copy of each “hit.” Although this sounds burdensome, it need not be.
Counsel does not have to review these documents, only see that they are retained. Forexample, counsel could create a broad list of search terms, run a search for a limitedtime frame, and then segregate responsive documents. When the opposing partypropounds its document requests, the parties could negotiate a list of search terms tobe used in identifying responsive documents, and counsel would only be obliged toreview documents that came up as “hits” on the second, more restrictive search. Theinitial broad cut merely guarantees that relevant documents are not lost.
In short, it is not sufficient to notify all employees of a litigation hold and expect thatthe party will then retain and produce all relevant information. . . . Counsel must takeaffirmative steps to monitor compliance so that all sources of discoverableinformation are identified and searched. This is not to say that counsel willnecessarily succeed in locating all such sources, or that the later discovery of newsources is evidence of a lack of effort. But counsel and client must take somereasonable steps to see that sources of relevant information are located.
Zubulake v. UBS Warburg LLC, 229 F.R.D. 422, 432 (S.D.N.Y. 2004).
Sanctions may be imposed against AZ under Rule 37(b)(2) based on its noncompliance with a court order, notwithstanding a lack of willfulness or bad faith, although such factors “are relevant . . . to the sanction to be imposed for the failure.” 8A Charles Alan Wright, Arthur R. Miller & Richard L. Marcus, FEDERAL PRACTICE & PROCEDURE § 2283, at 608 (2d ed.1994). Particularly in complex litigation, the rules and principles governing the imposition of sanctions in such litigation require special care because misconduct may have more severe consequences. MANUAL FOR COMPLEX LITIGATION § 10.151 (Fourth Edition 2004). “Sanctions proceedings can be disruptive, costly, and may create personal antagonism inimical to an atmosphere of cooperation. Moreover, a resort to sanctions may reflect a breakdown of case management. . . . On the other hand, the stakes involved in and the pressures generated by complex litigation may lead some parties to violate the rules. Although sanctions should not generally be a case management tool, a willingness to resort to sanctions, sua sponte if necessary, may ensure compliance with the management program. . . .
Although sanctions should be a last resort, they are sometimes unavoidable and may be imposed for general or specific deterrence, to punish, or to remedy the consequences of misconduct.” Id. Based on the testimony at the hearing, the Court is troubled by nature of the parties’ efforts to “meet and confer” on specific issues. One of the apparently successful efforts to collaborate on discovery, which led to cancellation of the June hearing, was, to an unacceptable degree, illusory.
AZ suspects that Plaintiffs have, to some degree, attempted to manufacture issues and to raise them just prior to scheduled status conferences so as to tarnish AZ in the eyes of the Court. This mistrust undermines the efficacy of the meet and confer requirement. AZ itself, despite what must be considerable expenditures in attempting to comply with discovery, has failed to bring appropriate personnel to the table at appropriate times to resolve non adversarial issues.
In this case, AZ never discussed with Plaintiffs which search terms to use as part of the search. There was no dialogue to discuss the search terms, as required by Rules 26 and 34. AZ eventually disclosed in April 2007 that a key word search had been conducted, not in seeking collaboration on the words to use, but rather as part of the dialogue on certifying the “custodial” production. More astounding is AZ’s continued failure to produce single-page TIFF documents that would be “usable” or “reasonably accessible” in accordance with the federal discovery rules and the Sedona Principles. AZ’s interpretation of CMO 2, that it did not explicitly require page breaks, is absurd – Mr. Dupre could not explain any other way the documents would be guaranteed to appear as “single pages.” Mr. Dupre attributed many of the severe problems with the load files and the metadata to vendor errors. According to the Sedona Principles14, cited by AZ several times at the hearing, a party is responsible for the errors of its vendors. Moreover, such problems in fundamental aspects of the production, worked on by different vendors, were inevitable in a 10 million page without the requisite quality control oversight. CONCLUSION
The Court finds that AZ has been “purposely sluggish” in making effective production to Plaintiffs.15 Given the Court’s mandate of a tight schedule in this case, AZ’s various decisions and problems that resulted in this sluggishness appears to have benefitted AZ by limiting the time available to Plaintiffs to review information and to follow up. This inference is informed by observations from other cases. The Ninth Circuit held in considering the delay in another multi-district case: Prejudice from unreasonable delay is presumed. In re Eisen, 31 F.3d at 1452-53.
Failure to produce documents as ordered is sufficient prejudice, whether or not thereis belated compliance. Id. at 1453 (taking action after the defendant’s motion todismiss was pending does not excuse taking no action before); Payne v. Exxon Corp.,121 F.3d 503, 508 (9th Cir.1997) (noting that last-minute tender of documents doesnot cure prejudice or restore other litigants on a crowded docket to the opportunityto use the courts); see also Adriana, 913 F.2d at 1413 n. 6 (recognizing that refusalto produce evidence presumptively shows that an asserted claim or defense ismeritless). The risk of prejudice is exacerbated where each delay potentially affectsthe discovery and remand schedule in hundreds of other cases. In re Phenylpropanolamine (PPA) Products Liability Litigation, 460 F.3d 1217, 1236-37 (9th Cir.
14“Ultimate responsibility for ensuring the preservation, collection, processing, and production of electronically stroed information rests with the party and its counsel, not with the nonparty consultant or vendor.” Sedona Principle 6.d.
15A prime example is AZ’s initial failure to implement Mr. Jaffe’s February suggestion to insert page breaks–an idea Mr. Dupre called ingenious–until May 30, and not reproducing the documents with page breaks until July 20. In a similar case in which the Second Circuit found that defendant’s “purposeful sluggishness” would warrant the imposition of sanctions, the defendant had hindered discovery of relevant evidence, even though defendant did not cause its destruction or unavailability, where the reason defendant did not produce the e-mails was that it hired a vendor that was unable to retrieve them in a timely fashion. Residential Funding Corp. v. DeGeorge Financial Corp., 306 F.3d 99, 110 & n. 5 (2nd Cir. 2002) (defendant’s decision to use an outside vendor to retrieve the emails rather than turn over the back-up tapes “led to much of the delay”). As further potential evidence of the defendant’s “purposeful sluggishness,” the court cited the lack of an explanation as to why emails from the back-up tapes were produced for nine months of 1998, but not the last four months during the negotiations at issue in the case, and defendant’s failure to explain its inability to retrieve the emails and why it failed to obtain outside assistance sooner. Id. at 111. Another factor the appellate court held was relevant for the trial court to consider was the reasonableness of defendant’s continued reliance on the ineffective vendor “throughout months of apparently fruitless attempts to retrieve the critical e-mails, in light of [opposing party’s] vendor to identify and begin to retrieve those e-mails in just four days.” Id. [A]s a discovery deadline or trial date draws near, discovery conduct that might havebeen considered “merely” discourteous at an earlier point in the litigation may wellbreach a party’s duties to its opponent and to the court. . . . [When defendant] hadrepeatedly missed deadlines to produce the e-mails - [defendant] was under anobligation to be as co-operative as possible. Viewed in that light, [defendant’s]“purposefully sluggish” acts - particularly its as-yet-unexplained refusal to answerbasic technical questions about the tape until prompted to do so by the District Court- may well have constituted sanctionable misconduct in their own right.
Similarly, in this case, AZ has not been as cooperative as possible in resolving the custodial issues. It is undisputed that the production “completed” on June 30, 2007 had load file, metadata, page break and key word search problems, making the 10 million pages of documents unaccessible, unsearchable, and unusable as contemplated under the Rules. It was not clear at the July 26 hearing, or even as of the date of this Order, that these profound technical issues have been resolved by the re-production efforts delivered to Plaintiffs on July 20, 2007. The Court finds that sanctions are warranted for AZ’s failure to produce “usable” or “reasonably accessible” documents.
However, the Court is unable to determine the appropriate nature and amount of sanctions at this time. Plaintiffs will be allowed a further opportunity to present evidence and argument as to any prejudice or damages from AZ’s failure timely to produce “usable” or “reasonably accessible” documents in this litigation, including motion costs. The Court will confer with the parties at the next status conference regarding further proceedings in light of the findings herein.
DONE and ORDERED in Orlando, Florida this 21st day of August,2007

Source: http://www.internetcases.com/library/cases/2007-08-21_in_re_seroquel.pdf


THERAPEUTISCHES DRUG MONITORING - TDM Im Unterschied zur Drogenanalytik, bei der der Einsatz von breiten Gruppen-Screeningtests zur Erfassung von Substanzen und deren relevanten Metabolite erwünscht ist, sollte in der Medikamentenanalytik die immunologische Nachweismethode präzise, richtig und spezi- fisch sein. Die Erfassung von Metaboliten ist hier in der Regel nicht erwünscht. Das ve

6-3/4 x 12-3/8

West-Ward Doxycycline Tabs Rev. 06/11 Flat Size: 6-3/4 x 12-3/8 Folded Size: 1-1/8 x 1-3/8 Type: 5 3/4 pt. Page 1 3/31/11 Proof 1 JB DOXYCYCLINE HYCLATE Dilution techniques: Use a standardized dilution method TABLETS, USP equivalent with tetracycline powder. The MIC values obtained should be interpreted accordingto the following criteria: Rev. 06/11 MIC (mcg/mL) Interpretation To r

© 2010-2017 Pdf Pills Composition