Com.tamhsc.edu

CURRICULUM VITAE
TRAVIS W. HEIN, Ph.D.
CONTACT INFORMATION
TAMUSCOM Medical Research Building, Room 106E EDUCATION
Postdoctoral Texas A&M University System Health Science Center. Field of Study:Training Cardiovascular Physiology, Microcirculatory Control. Mentors: Drs. Lih Kuo and Mariappan Muthuchamy (September 1997-August 1999).
Medical Sciences, Texas A&M University System Health Science Center,College Station, Texas. Major field: Medical Sciences. Mentor: Dr. Lih Kuo.
Dissertation Title: “Low-density lipoproteins impair coronary arteriolar function.”(August 1997).
St. Olaf College, Northfield, Minnesota. Major field: Biology. (May 1992).
Onalaska High School, Onalaska, Wisconsin. (May 1988).
PROFESSIONAL POSITIONS
Current
2003-present Assistant Professor, Department of Surgery, Division of Ophthalmology, Scott &
White Memorial Hospital, College of Medicine, Texas A&M University SystemHealth Science Center, Temple, Texas Previous
Research Assistant Professor, Department of Medical Physiology, College ofMedicine, Texas A&M University System Health Science Center, CollegeStation, Texas Assistant Research Scientist, Department of Medical Physiology, College ofMedicine, Texas A&M University System Health Science Center, CollegeStation, Texas Postdoctoral Research Associate, Department of Medical Physiology, College ofMedicine, Texas A&M University System Health Science Center, CollegeStation, Texas Graduate Assistant, Department of Medical Physiology, College of Medicine,Texas A&M University System Health Science Center, College Station, Texas TEACHING RESPONSIBILITIES
2001-present Advanced Cardiovascular Biology I (MPHY 604); Department of Medical Physiology; Texas A&M University System Health Science Center Cardiovascular Sciences (MSCI 689); Department of Medical Physiology; TexasA&M University System Health Science Center RESEARCH INTERESTS
∑ Cellular and molecular mechanisms of adenosine-induced dilation in the microcirculation
∑ Physiology and pathophysiology of coronary and retinal microcirculation ∑ Mechanisms involved in microvascular control of chronic inflammation ∑ Neurogenic regulation of microvascular blood flow ∑ Influence of exercise on coronary microcirculation ∑ Metabolic regulation of microvascular blood flow ∑ Nitric oxide and microvascular function SOCIETY MEMBERSHIP
1998-present The Microcirculatory Society1998-present American Heart Association, Council on Basic Cardiovascular Sciences2000-present The American Physiological Society2003-present The Association for Research in Vision and Ophthalmology INVITED PRESENTATIONS-NATIONAL MEETINGS
Presented: “Characterization of adenosine receptor-mediated dilation of porcine coronaryarterioles” at the American Heart Association meeting, 70th Scientific Sessions, Orlando,Florida, November 1997.
Presented: “Low-density lipoproteins impair nitric oxide-related endothelial function incoronary arterioles” at the American Heart Association meeting, 70th Scientific Sessions,Orlando, Florida, November 1997.
Presented: “Ischemia/reperfusion inhibits nitric oxide-mediated dilation in coronaryarterioles by upregulation of arginase” at the American Heart Association meeting, 73rdScientific Sessions, New Orleans, Louisiana, November 2000.
Presented: “Heterogeneous coronary arteriolar dilation to ß -adrenergic receptor activation: channels” at the American Heart Association meeting, 74th Scientific Sessions, Anaheim, California, November 2001.
Presented: “Elevated intraocular pressure inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles: role of superoxide” at the Association for Researchin Vision and Ophthalmology annual meeting, Fort Lauderdale, Florida, April 2004.
HONORS AND AWARDS
Graduated cum laude, St. Olaf College, Northfield, Minnesota Research Award, 3rd Place, Seventh Annual Graduate Research Symposium andPoster Competition, Texas A&M Health Science Center, College Station, TX August Krogh Young Investigator Award, Microcirculatory Society Scientist Development Grant, American Heart Association National Center Cardiovascular Section New Investigator Award, American Physiological Society Organized and Chaired Featured Topic at Experimental Biology Meeting forAmerican Physiological Society Cardiovascular Section COMMITTEES AND SERVICES
Treasurer, Graduate Student Organization, College of Medicine, Texas A&MUniversity Membership Committee, The Microcirculatory Society 2003-present Abstract grader, American Heart Association, Annual Scientific Session2004 Editorial Board of American Journal of Physiology: Heart & CirculatoryPhysiology JOURNAL REVIEWER
American Journal of Physiology: Heart and Circulatory PhysiologyInvestigative Ophthalmology and Visual ScienceJournal of Applied PhysiologyJournal of Vascular ResearchCirculation Research GRANT REVIEWS
Merit Review, Endocrinology Review Board, Department of Veterans Affairs’Medical Research Service, VA Medical Center (February) Research Peer Review Committee, American Heart Association Western ReviewConsortium CURRENT-PENDING GRANT/FUNDING SUPPORT
Current:
2002-2006
AHA National- Scientist Development GrantConducted Dilation of Coronary Arterioles and Role of Inward RectifierPotassium ChannelsRole: Principal Investigator 2002-present Characterization of vasoregulatory mechanisms in the retinal microcirculation (Ophthalmic Vascular Research Program)Sponsor: Scott & White Research FoundationRole: Co-Investigator Pending:
2004-2009
NIH RO1 EY016221-01Mechanisms of retinal arteriolar dilation to adenosineRole: Principal Investigator STUDENTS/POSTDOCTORATES/COLLEAGUES-TRAINED/MENTORED
Cuihua Zhang, M.D., Ph.D, postdoctorate, 9/97-8/2003- Cardiovascular physiology andmicrocirculatory control. Current position: Assistant Professor, Louisiana State UniversityHealth Center Wei Wang, M.D., postdoctorate, Texas A&M University System Health Science Center -Cardiovascular physiology. 9/99-present Erion Qamirani, graduate student, Texas A&M University System Health Science Center -C-reactive protein and coronary arteriolar function, 9/02-present Robert H. Rosa, Jr., M.D., Associate Professor of Ophthalmology, Chief, Section ofOphthalmic Pathology, Scott & White Eye Institute, Texas A&M University SystemHeatlh Science Center- Trained in isolated retinal microvessel techniques, 11/02-present Andrew Bossen, medical student, Texas A&M University System Health Science Center -Development of animal model for elevated intraocular pressure, 11/03 Habib Razavi, postdoctorate, Texas A&M University System Health Science Center -Conducted vasodilation and coronary arteriolar function, 11/03-present Zhaoxu Yuan, postdoctoral fellow, Scott & White Memorial Hospital- Vascular regulation
in retinal microcirculation, 11/03-present
GRADUATE STUDENT COMMITTEE
Erion Qamirani, Texas A&M University System Health Science Center, 6/03-present RESEARCH PUBLICATIONS
A. Peer-Reviewed Publications
Hein TW, Kuo L. LDLs impair vasomotor function of the coronary microcirculation: roleof superoxide anions. Circ Res. 83:404-414, 1998.
Liao JC, Hein TW, Vaughn MW, Huang K-T, Kuo L. Intravascular flow decreaseserythrocyte consumption of nitric oxide. Proc Natl Acad Sci USA. 96:8757 8761, 1999.
Hein TW, Kuo L. cAMP-independent dilation of coronary arterioles to adenosine: role ofnitric oxide, G proteins, and K channels. Circ Res. 85:634-642, 1999.
Hein TW, Belardinelli L, Kuo L. Adenosine A receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. JPharmacol Exp Ther. 291:655-664, 1999.
Hein TW, Liao J, Kuo L. Oxidized LDL specifically impairs endothelium dependent, NO-mediated dilation of coronary arterioles. Am J Physiol. 278:H175-H183, 2000.
Zhang C, Hein TW, Kuo L. Transmural difference in coronary arteriolar dilation toadenosine: effect of luminal pressure and K channels. Am J Physiol. 279:H2612-H2619, Hein TW, Wang W, Zoghi B, Muthuchamy M, Kuo L. Functional and molecularcharacterization of receptor subtypes mediating microvascular dilation to adenosine. J MolCell Cardiol. 33:271-282, 2001.
Zhang C, Hein TW, Wang W, Chang C-I, Kuo L. Constitutive expression of arginase incoronary microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory 1 0 . 1 0 9 6 / f j . 0 0 - 0 6 8 1 f j e (http://www.fasebj.org/cgi/doi/10.1096/fj.00-0681fje); FASEB J. 15:1264-1266, 2001.
Kuo L, Hein TW. Functional and molecular evidence of adenosine A receptor in coronary arteriolar dilation to adenosine. Drug Dev Res. 52:350-356, 2001.
10. Hein TW, Platts SH, Waitkus-Edwards KR, Kuo L, Mousa SA, Meininger GA. Integrin- binding peptides containing RGD produce coronary arteriolar dilation via cyclooxygenaseactivation. Am J Physiol. 281: H2378-H2384, 2001.
11. Rivers R, Hein TW, Zhang C, Kuo L. Activation of barium-sensitive inward rectifier potassium channels mediates remote dilation of coronary arterioles. Circulation. 104:1749-1753, 2001.
12. Huang K-T, Han TH, Hyduke DR, Vaughn MW, Van Herle, Hein TW, Zhang C, Kuo L, Liao JC. Modulation of nitric oxide bioavailability by erythrocytes. Proc Natl Acad SciUSA. 98:11771-11776, 2001.
13. Gamperl AK, Hein TW, Kuo L, Cason, BA. Isoflurane-induced dilation of porcine coronary microvessels is endothelium dependent and inhibited by glibenclamide.
Anesthesiology. 96:1465-1471, 2002.
14. Zhang C, Hein TW, Wang W, Kuo L. Divergent roles of angiotensin II AT and AT receptors in modulating coronary microvascular function. Circ Res. 92:322-329, 2003.
15. Hein TW, Zhang C, Wang W, Chang C-I, Thengchaisri N, Kuo L. Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting roleof arginase. FASEB J. (October 16, 2003) 10.1096/fj.03-0115fje (http://www.fasebj.org/cgi/doi/10.1096/fj.03-0115fje); FASEB J. 17:2328-2330, 2003.
16. Hein TW, Zhang C, Wang W, Kuo L. Transmural difference in coronary arteriolar dilation to ß-adrenergic receptor activation: role of ß -adrenergic receptors and K 17. Zhang C, Hein TW, Wang W, Kuo L. Tumor necrosis factor-induced production of superoxide inhibits endothelium-dependent NO-mediated dilation of coronary arterioles:role of ceramide signaling and xanthine oxidase. Submitted to Circ Res., 2004.
18. Zhang C, Hein TW, Wang W, Miller MW, Fossum T, Humphrey JD, Kuo L. Hypertension impairs nitric oxide-mediated dilation of coronary arterioles by upregulation of vasculararginase. Submitted to Hypertension, 2004.
19. Qamirani E, Wu X, Davis MJ, Kuo L, Hein TW. Differential effects of C-reactive protein on coronary arteriolar function. Submitted to Circulation, 2004.
20. Hein TW, Wang W, Rosa RH Jr, Kuo L. Requisite roles of A receptors and K in retinal arteriolar dilation to adenosine. Submitted to Invest Ophthalmol Vis Sci., 2004.
B. Book Chapters
1. Kuo L, Hein TW. Mechanism of shear stress-induced coronary microvascular dilation. In:
Sensors and Sensing in Biology and Engineering, edited by FG Barth, JAC Humphrey, andTW Secomb. Springer-Verlag Wien, New York, 2003.
C. Conference Chapters
1.
Thengchaisri N, Hein TW, Zhang C, Wang W, Kuo L. Upregulation of endothelial arginaseby oxidative stress impairs NO-mediated vasodilation. Proceedings of the 7th WorldCongress for Microcirculation, 579-584, Monduzai Editore, NelserBo-Bologna, Italy,2001.
D. Abstracts
Schmiege LM, Liao JC, Ghosheh SA, Hein TW, Miller SM, Kuo L. Effects of endotoxinand low-density lipoprotein on the L-arginine transport of endothelial cells.
Microcirculation. 2:94, 1995.
Hein TW, Kuo L. Oxidized-LDL impairs endothelium-dependent nitric oxide-mediateddilation of coronary arterioles. Microcirculation. 3:89,1996.
Hein TW, Kuo L. Oxidized low-density lipoprotein impairs nitric oxide-mediated dilationof coronary arterioles. Circulation. 94: I-426, 1996.
Hein TW, Kuo L. Native low-density lipoprotein impairs endothelium-dependent and nitricoxide-mediated dilation in porcine coronary arterioles. Microcirculation. 4:171, 1997.
Hein TW, Gamperl AK, Kuo L, Cason BA. Isoflurane-induced dilation of porcine coronaryarterioles is inhibited by glyburide. Anesthesiology. 87:3, 1997.
Hein TW, Kuo L. Characterization of adenosine receptor-mediated dilation of porcinecoronary arterioles. Circulation. 96:I114, 1997.
Hein TW, Kuo L. Oxidized LDL specifically impairs nitric oxide-mediated dilation ofcoronary arterioles. Circulation. 96:I316, 1997.
Hein TW, Kuo L. Low-density lipoproteins impair nitric oxide-related endothelial functionin coronary arterioles. Circulation. 96:I447, 1997.
Hein TW, Kuo L. Differential effect of oxidized low-density lipoprotein on nitric oxide-and potassium channel-mediated dilation of coronary arterioles. FASEB J. 12:A239, 1998.
10. Hein TW, Kuo L. cAMP-independent dilation of coronary arterioles to adenosine: role of channels. FASEB J. 12:A13, 1998.
11. Zhang C, Hein TW, Kuo L. Intraluminal pressure influences K coronary arteriolar dilation. Circulation. 98:I139, 1998.
channel-mediated coronary arteriolar dilation to adenosine is independent of cAMP. Circulation. 98:I139, 1998.
13. Hein TW, Kuo L. cAMP-independent dilation of coronary arterioles to isoproterenol: role channels. Circulation. 98:I139, 1998.
14. Hein TW, Ma Y, Muthuchamy M, Kuo L. Functional and molecular studies of adenosine channels in the coronary microcirculation. Circulation. 98:I139, 1998.
15. Hein T, Muthuchamy M, Kuo L. Mechanism of coronary arteriolar dilation to adenosine.
16. Meininger GA, Waitkus KR, Hein TW, Kuo L, Davis GE. Regulation of vasomotor function by integrins. J. Vasc. Res. 36:424, 1999.
17. Zhang C, Hein T, Kuo L. Regulation of nitric oxide-mediated dilation by arginase in coronary arterioles. FASEB J. 14:A29, 2000.
18. Kuo L, Hein T, Wang W, Zoghi B, Muthuchamy M. Functional and molecular evidence of adenosine A receptor in coronary arteriolar dilation to adenosine. Drug Develop. Res.
19. Hein TW, Zhang C, Wang W, Kuo L. Ischemia/reperfusion inhibits nitric oxide-mediated dilation in of arterioles by upregulation of arginase. Circulation. 102:II229, 2000.
20. Zhang C, Hein TW, Kuo L. Angiotensin II AT receptor mediates potentiation of coronary arteriolar constriction to phenylephrine. FASEB J. 15:A51, 2001.
21. Hein TW, Zhang C, Wang W, Kuo L. Upregulation of arginase in coronary microcirculation by ischemia/reperfusion inhibits nitric oxide-mediated vasodilation.
FASEB J. 15:A462, 2001.
22. Gaffin R, Boswell N, Hein T, Kuo L, Muthuchamy M. Impaired adenosine-induced dilation in coronary arteries from transgenic mouse hearts expressing a familialhypertrophic cardiomyopathy mutation. FASEB J. 15:A765, 2001.
23. Rivers R, Zhang C, Hein TW, Kuo L. Conducted remote dilations of isolated coronary arterioles require activation of barium-sensitive inward rectifier potassium channels.
Circulation. 104:II32, 2001.
24. Hein TW, Zhang C, Kuo L. Heterogeneous coronary arteriolar dilation to ß -adrenergic receptor activation: role of nitric oxide and K channels. Circulation. 104:II138, 2001.
25. Zhang C, Hein TW, Kuo L. Activation of angiotensin II AT1 receptor inhibits endothelium-dependent nitric oxide-mediated dilation of coronary arterioles: role ofsuperoxide anion. Circulation. 104:II174, 2001.
26. Fogarty JA, Hein TW, Zhang C, Parker JL, Kuo L. Adenosine-stimulated production of nitric oxide in porcine collateral-dependent coronary arterioles is enhanced by exercisetraining. Circulation. 104:II175, 2001.
27. Fogarty JA, Hein TW, Zhang C, Kuo L, Parker JL. Exercise training enhances basal and VEGF-stimulated nitric oxide production in porcine collateral-dependent coronaryarterioles. Circulation. 104:II265, 2001.
28. Thengchaisri N, Wang W, Chang C, Hein TW, Kuo L. Hydrogen peroxide specifically impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles: roleof arginase. Circulation. 104:II286, 2001.
29. Zhang C, Hein TW, Kuo L. Stimulation of a - and ß -adrenergic receptors by norepinephrine elicits endothelium-dependent nitric oxide-mediated dilation of coronaryarterioles. FASEB J. 16:A125, 2002.
30. Han TH, Huang KT, Hyduke DR, Vaughn MW, van Herle H, Hein TW, Zhang C, Kuo L, Liao. Modulation of nitric oxide bioavailability by erythrocytes. FASEB J. 16:A913, 2002.
31. Zhang C, Hein TW, Wang W, Kuo L. Tumor necrosis factor-induced production of superoxide inhibits endothelium-dependent NO-mediated dilation of coronary arterioles:role of ceramide signaling and xanthine oxidase. FASEB J. 17:A138, 2003.
32. Zhang C, Hein TW, Wang W, Miller MW, Fossum T, Humphrey JD, Kuo L. Hypertension impairs NO-mediated dilation of coronary arterioles by upregulation of endothelialarginase. FASEB J. 17:A504, 2003.
33. Hein TW, Wang W, Rosa RH, Kuo L. Requisite roles of A receptors and K in retinal arteriolar dilation to adenosine. Invest Ophthalmol Vis Sci. 2003;44:E-Abstract327.
34. Rosa RH, Hein TW, Kuo L. Activation of a -adrenergic receptors by brimonidine evokes nitric oxide-mediated dilation of retinal microvessels. Invest Ophthalmol Vis Sci.
2003;44:E-Abstract 958.
35. Zhang C, Hein TW, Wang W, Kuo L. Tumor necrosis factor-alpha-induced activation of JNK impairs nitric oxide-mediated dilation of coronary arterioles. Circulation. 108:IV-79,2003.
36. Wang W, Zhang C, Hein TW, Kuo L. Oxidized low-density lipoprotein impairs nitric oxide-mediated dilation of coronary arterioles via upregulation of endothelial arginase.
Circulation. 108:IV-99, 2003.
37. Qamirani E, Hein TW, Kuo L. C-Reactive protein dilates coronary arterioles via barium- sensitive inward rectifier potassium channels. Circulation. 108:IV-226, 2003.
38. Qamirani E, Wang W, Kuo L, Hein TW. C-Reactive protein inhibits endothelium- dependent nitric oxide-mediated dilation in coronary arterioles: roles of superoxide andvascular NADPH oxidase. FASEB J. 18:A622, 2004.
39. Shipley R, Hein TW, Kuo L. Acidosis enhances vasodilation of coronary arterioles to channels. FASEB J. 18:A250, 2004.
40. Hein TW, Bossen A, Yuan J, Rosa RH Jr, Kuo L. Elevated intraocular pressure inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles: role ofsuperoxide anion. Invest Ophthalmol Vis Sci. 2004;45:E-Abstract 2337.
41. Rosa RH, Hein TW, Kuo L. Retinal autoregulation: The myogenic response in retinal arterioles. Invest Ophthalmol Vis Sci. 2004;45:E-Abstract 2335.

Source: http://com.tamhsc.edu/research/centers/cvri/investigators/files/CV_TWH.pdf