Pharmacokinetic parameters of Gtfx after oral administration in dogs( n = 4) Concentration - time curves of Gtfx after oral administration in dogs serum( n = 4)
Perry CM , Balfour JAB , Lamb HM. Catifloxacin[J ] . Drugs ,1999 ,58
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1994-2007 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.netTherapeutic effects of Erigeron breviscapus on cerebralvascular spasm after subarachnoid hemor2 rhage of SD rats
DONG Ling - lin1 , LUO Zu - ming2 , YANG Xu - hong2
(1. Department of Neurology , Sichuan Provincial People s Hospital , Chengdu 610072 , China ;2. Department of Neurology , West China Hospi2
tal , Sichuan University , Chengdu 610041 , China)Abstract : OBJECTIVE
To explore therapeutic effects of Erigeron breviscapus and mechanisms of cerebral vascular spasm(CVS) after exper2
imental Subarachnoid hemorrhage(SAH) . METHODS
Forty - eight SD rats were divided randomly into four groups : control group ,cerebral
vasospasm group , Erigeron breviscapus group and Nimotip group . Experimental SAH in SD rats was made by injecting blood for two times. Basi2
lar artery diameter changes were monitored by stereotype microscopy. The levels of ET - 1 in plasm and NO in serum were measured by ra2
dioimmunoassay ,enzymology ,respectively at different times. RESUL TS
Compared with cerebral vasospasms group ,basilar artery diameters in
Erigeron breviscapus group dilated significently( P < 0. 01) . The levels of ET - 1 in plasma were increased ,yet NO were decreased in cerebral
vasospasm group compared with control group ( P < 0. 01) . In Erigeron breviscapus group ,the levels of ET - 1 were decreased and NO in2
creased compared with cerebral vasospasm( P < 0. 01) . CONCL USION Eigeron breviscapus can inhibit increase of ET - 1 and decrease of
NO to prevent and treat CVS following SAH. Key words : Erigeron breviscapus ;Subarachnoid hemorrhage ;Cerebrovascular spasm ;Basilary artery ; ET - 1 ;NO CLC number :R965 Document code :A Article ID :1006 - 0103 (2006) 01 - 0035 - 03 Comparision of basilar artery diameter among groups( x
Compared with pre - operation and control group : 3 P < 0. 1 ;compared with
P < 0101 ;compared with Nimotip group :
1994-2007 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net10 - 5 g ml - 1 , x Comparision of the ET - 1 in plasma( 10 - 5 g ml - 1 , x
Compared with control group : 3 P < 0101 ;compared with SAH model group :
( mol L - 1 , x Comparision of the NO in Serum( mol L - 1 , x
Compared with control group : 3 P < 0101 ;compared with SAH model group :
Kelm M , Feelisch M , Spahr R , et al . Quantitative and kinetic char2
acterization of nitric Oxide and EDRF released from cultured endothe2
lial ceels[J ] . Biochem Biophys Res Commun ,1998 ,154 :236
Liszczak TM. Cerebrallarterinal constrinetion after experimental sub2
arachnoid hemorrhage is assoiciated with blood componertsnith in the
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1994-2007 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net
from 1995 The Demon-Haunted World: Carl Sagan’s “Baloney Detection Kit” What’s in the kit? Tools for skeptical thinking. What skeptical thinking boils down to is the means to construct and to understand, a reasoned argument and—especially important—to recognize a fallacious or fraudulent argument. The question is not whether we like the conclusion that emerges out of a train of
McDonald's USA Ingredients Listing for Popular Menu Items Provided below is a listing of components in our popular menu items by category, followed by the ingredient statements for those components. Allergens containedwithin these components are indicated in capital type at the end of each respective ingredient statement. We encourage customers to check these statementsregularly as ingredie