AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 1 of 9 Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME AGRI WEST AW FEARSOME 500 FUNGICIDE PRODUCT USE Fungicide. SUPPLIER Company: Agri West Address: 42 Newmarket Street Hendra QLD, 4011 Australia Telephone: +61 7 3856 5553 Emergency Tel:1800 039 008 (24HRS) Fax: +61 7 3268 1434 Section 2 - HAZARDS IDENTIFICATION STATEMENT OF HAZARDOUS NATURE HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to NOHSC Criteria, and ADG Code. RISK Risk Codes
• Harmful by inhalation, in contact with skin and ifswallowed.
• Harmful to aquatic organisms, may cause long- term adverseeffects in the aquatic environment. SAFETY Safety Codes
• Do not breathe gas/ fumes/ vapour/ spray.
• Use only in well ventilated areas.
• Keep container in a well ventilated place.
• Avoid exposure - obtain special instructions before use.
• To clean the floor and all objects contaminated by thismaterial, use water.
• Keep away from food, drink and animal feeding stuffs.
• If swallowed, IMMEDIATELY contact Doctor or PoisonsInformation Centre (show this container or label). Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
(500g/L)ingredients nonhazardous proprietary
continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 2 of 9 Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS Section 4 - FIRST AID MEASURES SWALLOWED • For advice, contact a Poisons Information Centre or a doctor. • If swallowed do NOT induce vomiting. • If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. • Observe the patient carefully. • Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious • Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink. • Seek medical advice. EYE ■ If this product comes in contact with the eyes: • Wash out immediately with fresh running water. • Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. • Seek medical attention without delay; if pain persists or recurs seek medical attention. • Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. SKIN ■ If skin contact occurs: • Immediately remove all contaminated clothing, including footwear. • Flush skin and hair with running water (and soap if available). • Seek medical attention in event of irritation. INHALED • If fumes or combustion products are inhaled remove from contaminated area. • Lay patient down. Keep warm and rested. • Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. • Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary. • Transport to hospital, or doctor. NOTES TO PHYSICIAN ■ Treat symptomatically. Section 5 - FIRE FIGHTING MEASURES EXTINGUISHING MEDIA • There is no restriction on the type of extinguisher which may be used. FIRE FIGHTING • Alert Fire Brigade and tell them location and nature of hazard. • Wear breathing apparatus plus protective gloves for fire only. • Prevent, by any means available, spillage from entering drains or water courses. • Use fire fighting procedures suitable for surrounding area. • DO NOT approach containers suspected to be hot. • Cool fire exposed containers with water spray from a protected location. • If safe to do so, remove containers from path of fire. • Equipment should be thoroughly decontaminated after use. continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 3 of 9 Section 5 - FIRE FIGHTING MEASURES FIRE/EXPLOSION HAZARD • Non combustible. • Not considered to be a significant fire risk. • Expansion or decomposition on heating may lead to violent rupture of containers. • Decomposes on heating and may produce toxic fumes of carbon monoxide (CO). • May emit acrid smoke. Other decomposition products include: carbon dioxide (CO2), nitrogen oxides (NOx), phosphorus oxides (POx), hydrogen fluoride. FIRE INCOMPATIBILITY ■ None known. HAZCHEM None Personal Protective Equipment Breathing apparatus. Chemical splash suit. Section 6 - ACCIDENTAL RELEASE MEASURES MINOR SPILLS • Clean up all spills immediately. • Avoid breathing vapours and contact with skin and eyes. • Control personal contact by using protective equipment. • Contain and absorb spill with sand, earth, inert material or vermiculite. • Wipe up. • Place in a suitable, labelled container for waste disposal. MAJOR SPILLS ■ Minor hazard. • Clear area of personnel. • Alert Fire Brigade and tell them location and nature of hazard. • Control personal contact by using protective equipment as required. • Prevent spillage from entering drains or water ways. • Contain spill with sand, earth or vermiculite. • Collect recoverable product into labelled containers for recycling. • Absorb remaining product with sand, earth or vermiculite and place in appropriate containers for disposal. • Wash area and prevent runoff into drains or waterways. • If contamination of drains or waterways occurs, advise emergency services. Personal Protective Equipment advice is contained in Section 8 of the MSDS. Section 7 - HANDLING AND STORAGE PROCEDURE FOR HANDLING • Limit all unnecessary personal contact. • Wear protective clothing when risk of exposure occurs. • Use in a well-ventilated area. • When handling DO NOT eat, drink or smoke. • Always wash hands with soap and water after handling. • Avoid physical damage to containers. • Use good occupational work practice. • Observe manufacturer's storing and handling recommendations. continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 4 of 9 Section 7 - HANDLING AND STORAGE SUITABLE CONTAINER • Polyethylene or polypropylene container. • Packing as recommended by manufacturer. • Check all containers are clearly labelled and free from leaks. STORAGE INCOMPATIBILITY ■ Avoid contamination of water, foodstuffs, feed or seed. STORAGE REQUIREMENTS • Store in original containers. • Keep containers securely sealed. • Store in a cool, dry, well-ventilated area. • Store away from incompatible materials and foodstuff containers. • Protect containers against physical damage and check regularly for leaks. • Observe manufacturer's storing and handling recommendations. Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION EXPOSURE CONTROLS The following materials had no OELs on our records • flutriafol: MATERIAL DATA AGRI WEST AW FEARSOME 500 FUNGICIDE:
■ None assigned. Refer to individual constituents.
■ It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent) for all
substances for which there is evidence of health effects at airborne concentrations encountered in theworkplace.
At this time no TLV has been established, even though this material may produce adverse health effects (as
evidenced in animal experiments or clinical experience). Airborne concentrations must be maintained as low asis practically possible and occupational exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified (P.N.O.S) does NOT
Limited under EC Directive on drinking water quality 70/778/EEC. pesticides maximum admissable
Included in Schedule 6 (Release into Land: Prescribed substances)Statutory Instrument No. 472, 1991. PERSONAL PROTECTION EYE • Safety glasses. • Safety glasses with side shields. • Chemical goggles. • Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A
written policy document, describing the wearing of lens or restrictions on use, should be created for eachworkplace or task. This should include a review of lens absorption and adsorption for the class ofchemicals in use and an account of injury experience. Medical and first-aid personnel should be trained intheir removal and suitable equipment should be readily available. In the event of chemical exposure, begineye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed at thefirst signs of eye redness or irritation - lens should be removed in a clean environment only after workershave washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59]. continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 5 of 9 Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION HANDS/FEET ■ Wear chemical protective gloves, eg. PVC. Wear safety footwear. OTHER • Overalls. • Barrier cream • Eyewash unit. RESPIRATOR ■ Selection of the Class and Type of respirator will depend upon the level of breathing zone contaminant and the chemical nature of the contaminant. Protection Factors (defined as the ratio of contaminant outside and inside the mask) may also be important.
** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of personal protectiveequipment required. For further information consult site specific CHEMWATCH data (if available), or yourOccupational Health and Safety Advisor. ENGINEERING CONTROLS ■ General exhaust is adequate under normal operating conditions. If risk of overexposure exists, wear SAA approved respirator. Correct fit is essential to obtain adequate protection. Provide adequate ventilation in warehouse or closed storage areas. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES APPEARANCE Yellow liquid with fishy odour; disperses in water. PHYSICAL PROPERTIES Liquid. Mixes with water. continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 6 of 9 Section 10 - STABILITY AND REACTIVITY CONDITIONS CONTRIBUTING TO INSTABILITY • Presence of incompatible materials. • Product is considered stable. • Hazardous polymerisation will not occur. For incompatible materials - refer to Section 7 - Handling and Storage. Section 11 - TOXICOLOGICAL INFORMATION POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. Ingestion may result in nausea, abdominal irritation, pain and vomiting. EYE ■ If applied to the eyes, this material causes severe eye damage. SKIN ■ The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. INHALED ■ Harmful by inhalation. The material is not thought to produce respiratory irritation (as classified by EC Directives using animal models). Nevertheless inhalation of vapours, fumes or aerosols, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. CHRONIC HEALTH EFFECTS Evidence from animal tests indicate that repeated or prolonged exposure to flutriafol could result in liver and reproductive system disorders. TOXICITY AND IRRITATION AGRI WEST AW FEARSOME 500 FUNGICIDE: ■ Not available. Refer to individual constituents.
FLUTRIAFOL:■ unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
Dermal (rat) LD50: >1000 mg/kgInhalation (rat) LC50: 1.65 mg/l/4h *Oral (mouse) LD50: 179 mg/kgOral (rabbit) LD50: 200 mg/kgDermal (rabbit) LD50: 200 mg/kgNOEL (90d feeding)* rats 20 mg/kg dietdogs 5 mg/kgNon-teratogenic in rats and rabbitsToxicity Class WHO III; EPA III *Non-cytogenic in in vivo studies, non-mutagenic in Ames assay *
continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 7 of 9 Section 11 - TOXICOLOGICAL INFORMATION
Not a skin sensitiser in guinea pigs. * The Pesticide ManualADI: 0.01 mg/kg/dayNOEL: 1 mg/kg/day
Section 12 - ECOLOGICAL INFORMATION
FLUTRIAFOL:■ Toxic to aquatic organisms. Triazole fungicides share common metabolites, the triazole compounds 1,2,4-triazole (free triazole), triazolealanine, and triazole acetic acid,
In environmental fate studies, all three forms of triazole (1,2,4-T, TA,
and TAA) have been found and there is evidence that the three can inter-convert in soil and aquatic systemsAs a plant metabolite, and given the wide use of triazole-derivative pesticides (used as fungicides on manycrops as well as on turf) free triazole is found in a variety of food commodities, including animalbyproducts. 1,2,4-triazole appears to be relatively stable in the environment, and may be found in rotationalcrops as well as in water. Studies indicate that 1,2,4-triazole affects the central and peripheral nervous systems, reproductive tissuesof both sexes, and the hematological system. Developmental and reproductive effects have been noted for thiscompound. Based on the available metabolism data from rats and livestock, 1,2,4-triazole may form in humansfollowing exposure to parent triazole compounds. The available studies on triazole conjugates found developmental skeletal effects, decreased body weight andbody weight gain, and decreased leukocytes and triglycerides following exposure in animals. For azole-containing substances. Azole fungicides and systemically used antifungal drugs directly interfere with steroidogenesis by acting aspotent inhibitors of steroidogenic enzymes and are known to cause endocrine disruption mainly via thismechanism.
An important P450 enzyme involved in the steroidogenesis is aromatase. Aromatase demethylates C10 andspecifically converts androstenedione and testosterone. On the protein level, the amino acid sequencehomology between aromatase from fish and humans is about 50% and between rats and humans is about 78% .Inmammals, aromatase is mainly expressed in the brain and the gonads, but it is also found in placental,adipose, and bone tissue . The physiologic balance between different sex steroid hormones is crucial for thedevelopment, maintenance, and function of the reproductive system as well as for the differentiation of thesexual phenotype during ontogeny. Oestrogens (estrone and estradiol) are products of the androgens(androstenedione and testosterone), and the reaction is catalysed by aromatase. In mammals, differentiationof the male phenotype depends not only on testosterone but also on estradiol generated from testosterone byneuronal aromatase in central nervous system. Therefore, disturbances in aromatase expression and/or changesin its catalytic activity are expected to exhibit negative effects on reproduction parameters
Azole-containing compounds produce profound effects in the environment. In part this is due to inhibition ofseveral enzyme systems including those involving sterol 14[alpha]-demethylase. Sterol 14[alpha]-demethylaseis a member of the superfamily of haeme-containing cytochrome P450 enzymes involved in metabolism ofendogenous and xenobiotic substances. The antifungal effect of azoles is due to inhibition of sterol14[alpha]-demethylase in fungi and yeast, thereby blocking the biosynthesis of ergosterol The subsequent lackof ergosterol is detrimental because ergosterol is an essential sterol component in the membranes of fungiand yeast. Sterol 14[alpha]-demethylase is not only expressed in fungi and yeast but is also found in manyother species ranging from bacteria to mammals. In plants, the sterol 14[alpha]-demethylase reactionmetabolises obtusifoliol and provides precursors for biosynthesis of phytosterols. In animals, the sterol14[alpha]-demethylase reaction is part of the metabolic pathway leading to biosynthesis of cholesterol. Cholesterol in turn is the substrate for the production of many other sterols (e.g., the sex steroidhormones).
The DNA sequences encoding sterol 14[alpha]-demethylase of many fungi and yeast are known, as well as thesequences of mice, rats, pigs, and humans . On the protein level, the amino acid sequences are highlyconserved along the phylogenetic tree. This fact is considered by many authors as an indication of thepivotal role of sterol 14[alpha]-demethylase in all organisms. The homology of the amino acid sequence level
continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 8 of 9 Section 12 - ECOLOGICAL INFORMATION
between rats and humans is 93% and 40% between fungi and humans. In humans, the sterol 14[alpha]-demethylaseis expressed in many different tissues. DO NOT discharge into sewer or waterways. Kow Log P = 2.3 (20 C)Flutriafol has no effect on microbial populations or on carbon or nitrogen transformations occurring in thesoil. Ecotoxicology:Birds: Acute oral LD50 for female mallard ducks: >5000 mg/kgFive day dietary LD50 for mallard ducks: 3940 ppmJapanese quail: 17100 ppmFish LC50: for rainbow trout 61 mg/l;mirror carp 77 mg/l; NOEC 6.2 mg/lBees: low toxicity to honey bees; Acute oral LD50: > 5 ug/beeDaphnia: EC50 (48 h): 78 mg/l
Ecotoxicity Ingredient Section 13 - DISPOSAL CONSIDERATIONS
• Recycle wherever possible or consult manufacturer for recycling options. • Consult State Land Waste Management Authority for disposal. • Bury residue in an authorised landfill. • Recycle containers if possible, or dispose of in an authorised landfill. Section 14 - TRANSPORTATION INFORMATION HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS: ADG7, UN, IATA, IMDG
Section 15 - REGULATORY INFORMATION REGULATIONS Regulations for ingredients flutriafol (CAS: 76674-21-0) is found on the following regulatory lists; "Australia ADI list - Acceptable daily intakes for agricultural and veterinary chemicals","Australia Hazardous Substances","Australia New Zealand Food Standards Code - Maximum Residue Limits (Australia only) - Schedule 1","Australia Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) - Schedule 6" No data for Agri West AW Fearsome 500 Fungicide (CW: 26-0813) continued. AGRI WEST AW FEARSOME 500 FUNGICIDE Chemwatch Independent Material Safety Data Sheet Issue Date: 17-Mar-2011 CHEMWATCH 26-0813 NC317ECP Version No:2.0 CD 2011/1 Page 9 of 9 Section 16 - OTHER INFORMATION EXPOSURE STANDARD FOR MIXTURES ■ "Worst Case" computer-aided prediction of spray/ mist or fume/ dust components and concentration:
■ Composite Exposure Standard for Mixture (TWA) :5 mg/m³. ■ Operations which produce a spray/mist or fume/dust, introduce particulates to the breathing zone.
If the breathing zone concentration of ANY of the components listed below is exceeded, "Worst Case"
considerations deem the individual to be overexposed.
■ Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch Classification committee using available literature references. A list of reference resources used to assist the committee may be found at: www.chemwatch.net/references.
■ The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace or other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering controls must be considered. This document is copyright. Apart from any fair dealing for the purposes of private study, research, review orcriticism, as permitted under the Copyright Act, no part may be reproduced by any process without writtenpermission from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 17-Mar-2011Print Date: 17-Mar-2011
Journal of Nuclear Medicine, published on April 10, 2013 as doi:10.2967/jnumed.112.112177 Reporting Guidance for Oncologic 18F-FDG PET/CT ImagingRyan D. Niederkohr1, Bennett S. Greenspan2, John O. Prior3, Heiko Schöder4, Marc A. Seltzer5,Katherine A. Zukotynski6,7, and Eric M. Rohren81Department of Nuclear Medicine, Kaiser Permanente Medical Center, Santa Clara, California; 2Department of Ra
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