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Publications Dr. W.M.A. Niessen
In refereed scientific journals:
C.P. Terweij-Groen, J.C. Kraak, W.M.A. Niessen, J.F. Lawrence, C.E. Werkhoven-Goewie, U.A.Th.
Brinkman, and R.W. Frei, An ion pair extraction detector for the liquid chromatographicdetermination of anionic surfactants. Int. J. Environ. Anal. Chem., 9 (1981) 45-57.
C.E. Werkhoven-Goewie, W.M.A. Niessen, U.A.Th. Brinkman, and R.W. Chromatographic detector for organosulphur compounds based on a ligand-exchange reaction. J.
Chromatogr., 203 (1981) 165-172.
W.M.A. Niessen and H. Poppe, Open tubular liquid chromatography / mass spectrometry usingdirect liquid introduction. J. Chromatogr., 323 (1985) 37-46.
W.M.A. Niessen, H.P.M. van Vliet, and H. Poppe, Studies on external band broadening in opentubular liquid chromatography using peak deconvolution methods based on the exponentiallymodified gauss model. Chromatographia, 20 (1985) 357-363.
W.M.A. Niessen, A review of direct liquid introduction interfacing for LC/MS. Part I: Instrumentalaspects. Chromatographia, 21 (1986) 277-287.
W.M.A. Niessen, A review of direct liquid introduction interfacing for LC/MS. Part II: Massspectrometry and applications. Chromatographia, 21 (1986) 342-354.
J.W. Elgersma, F.J.M.J. Maessen, and W.M.A. Niessen, A low consumption thermospray nebulizerwith a fused silica vaporizer for inductively coupled plasma atomic emission spectrometry.
Spectrochim. Acta, 41B (1986) 1217-1220.
W.M.A. Niessen and H. Poppe, Open tubular liquid chromatography / mass spectrometry with acapillary inlet interface. J. Chromatogr., 385 (1987) 1-15.
W.M.A. Niessen and H. Poppe, Problems in interfacing open tubular liquid chromatography andmass spectrometry. J. Chromatogr., 394 (1987) 21-34 C.E.M. Heeremans, G.F. LaVos, J.M. te Koppele, J. Brussee, W.M.A. Niessen, M.C. ten Noever deBrauw, and J. van der Greef, Off-line LC-FAB-MS/MS analysis of two diastereomeric gluthathioneconjugates of alpha-bromoisovalerylurea. Bimed. Environ. Mass Spectrom., 17 (1988) 181-186.
R.J. Vreeken, W.M.A. Niessen, and J. van Thuyl, Identification of artefacts and reduction of artefactformation in the desorption of active charcoal tubes with carbon disulphide and methanol. Int. J.
Environ. Anal. Chem., 33 (1988) 23-33.
J. van der Greef, W.M.A. Niessen and U.R. Tjaden, Liquid chromatography mass spectrometry inbioanalysis: some applications and a new approach for non-volatile buffer systems. J. Pharm.
Biomed. Anal., 6 (1988) 565-571.
E.R. Verheij, H.J.E.M. Reeuwijk, G.F. LaVos, W.M.A. Niessen, U.R. Tjaden and J. van der Greef,Phase-system switching: a new approach in LC/MS coupling. Biomed. Environ. Mass Spectrom., 16(1988) 393-399.
C.E.M. Heeremans, R.A.M. van der Hoeven, G.F. LaVos, W.M.A. Niessen, U.R. Tjaden, J. van derGreef, Structure elucidation of Mitomycin C metabolites. I. The applicability of various massspectrometric techniques in metabolic studies on Mitomycin C. Biomed. Environ. Mass Spectrom.,17 (1988) 377-382.
W.M.A. Niessen, P.J.M. Bergers, U.R. Tjaden and J. van der Greef, Phase-system switching as an on-line sample pretreatment in the bioanalysis of Mitomycin C in plasma using supercritical fluidchromatography. J. Chromatogr., 454 (1988) 243-251.
E.R. Verheij, G.F. LaVos, W. v.d. Pol, W.M.A. Niessen and J. Van der Greef, Identification ofdiuron and four of its metabolites in human plasma and urine using LC/MS with a moving beltinterface. J. Anal. Toxicol., 13 (1989) 8-12.
W.M.A. Niessen, M.A.G. de Kraa, E.R. Verheij, P.J.M. Bergers, G.F. LaVos, U.R. Tjaden and J. vander Greef, Combined Supercritical Fluid Chromatography Mass Spectrometry in the analysis ofdiuron in plasma using on-line phase-system switching. Rapid Commun. Mass Spectrom., 3 (1989)1-4.
C.E.M. Heeremans, R.A.M. van der Hoeven, W.M.A. Niessen, U.R. Tjaden and J. van der Greef,Acetic acid cluster ions for tuning and calibration in thermospray LC/MS. Org. Mass Spectrom., 24(1989) 109-112.
C.E.M. Heeremans, R.A.M. van der Hoeven, W.M.A. Niessen, J. Vuik, R.H. de Vos, and J. van derGreef, Specific screening methods for glucosinolates in sprout extracts using on-line thermosprayliquid chromatography tandem mass spectrometry. J. Chromatogr., 472 (1989) 219-229.
P. Kokkonen, G.-J. ten Hove, W.M.A. Niessen, G. van der Werken, U.R. Tjaden and J. van derGreef, Separation and identification of intact glucosinolates using direct coupling of high-performance liquid chromatography with frit-fast atom bombardment mass spectrometry. RapidCommun. Mass Spectrom., 3 (1989) 102-106.
J. van der Greef, W.M.A. Niessen and U.R. Tjaden, Liquid Chromatography - Mass Spectrometry:The need for a multidimensional approach. J. Chromatogr., 474 (1989) 5-19.
P. Kokkonen, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Applicability of Continuous-FlowFast Atom Bombardment in bioanalysis: dextromethorphan in plasma. J. Chromatogr., 474 (1989)58-68.
W.M.A. Niessen, R.A.M. van der Hoeven, M.A.G. de Kraa, C.E.M. Heeremans, U.R. Tjaden en J.
van der Greef, Repeller effects in discharge ionization in combined liquid or supercritical fluidchromatography mass spectrometry using a thermospray interface. Part I: Changes in the reagent gasspectrum. J. Chromatogr., 474 (1989) 113-122.
C.E.M. Heeremans, R.A.M. van der Hoeven, W.M.A. Niessen, U.R. Tjaden and J. van der Greef,Development of optimization strategies in thermospray liquid chromatography mass spectrometry. J.
Chromatogr., 474 (1989) 149-162.
A. Walhagen, L.-E. Edholm, C.E.M. Heeremans, R.A.M. van der Hoeven, W.M.A. Niessen, U.R.
Tjaden and J. van der Greef, Coupled Column Chromatography - Mass Spectrometry: ThermosprayLC/MS and LC/MS/MS analysis of metoprolol enantiomers in plasma using phase-system switching.
J. Chromatogr., 474 (1989) 257-263.
E.R. Verheij, G.F. LaVos, W.M.A. Niessen, U.R. Tjaden en J. van der Greef, Belt-speedprogramming, a new technique for peak compression in LC/MS en SFC/MS with moving-beltinterfaces. J. Chromatogr., 474 (1989) 275-283.
J. van der Greef, W.M.A. Niessen and U.R. Tjaden, Perspectives of the moving belt LC/MSinterface. Spectra., 12 (1989) 26-34.
W.M.A. Niessen, J. van der Greef and U.R. Tjaden, Bioanalytical applications of supercritical fluidchromatography. J. Chromatogr., 492 (1989) 167-188.
W.M.A. Niessen, R.A.M. van der Hoeven, M.A.G. de Kraa, C.E.M. Heeremans, U.R. Tjaden en J.
van der Greef, Repeller effects in discharge ionization in combined liquid or supercritical fluidchromatography mass spectrometry using a thermospray interface. Part II: Changes in some analytespectra. J. Chromatogr., 478 (1989) 325-338.
E. Karnaukhova, W.M.A. Niessen, U.R. Tjaden, J. Raap, J. Lugtenburg and J. van der Greef,Determination of deuterium-labelled tryptophan in proteins by means of high performance liquidchromatography and thermospray mass spectrometry. Anal. Biochem., 181 (1989) 271-275.
N.J. Reinhoud, L.G. Gramberg, E.R. Verheij, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Capillary electrophoresis mass spectrometry using continuous-flow fast atom bombardment. RapidCommun. Mass Spectrom., 3 (1989) 348-351.
W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Liquid chromatography mass spectrometry inbioanalysis: two applications, in: M.A. Brown (Ed.): Liquid Chromatography/Mass Spectrometry.
Applications in Agricultural, Pharmaceutical and Environmental Chemistry, ACS Symposium SeriesVol. 420, Ch. 11, (1990) 179-189.
P. Kokkonen, E. Schröder, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Important parametersin continuous-flow fast atom bombardment LC/MS. J. Chromatogr., 511 (1990) 35-47.
N.J. Reinhoud, E. Schröder, U.R. Tjaden, W.M.A. Niessen and J. van der Greef, Static and scanningarray detection in capillary electrophoresis - mass spectrometry. J. Chromatogr., 516 (1990) 147-155.
P.S. Kokkonen, J. van der Greef, E. Schröder, W.M.A. Niessen and U.R. Tjaden, A new target forContinuous-Flow Fast Atom Bombardment LC-MS allowing higher flow-rates. Org. MassSpectrom., 25 (1990) 566-568.
P.S. Kokkonen, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Phase-system switching incontinuous-flow fast atom bombardment liquid chromatography mass spectrometry. Rapid Commun.
Mass Spectrom., 5 (1991) 19-24.
P.S. Kokkonen, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Bioanalysis of erythromycin-2'-ethylsuccinate in plasma using phase-system switching continuous-flow fast atom bombardmentliquid chromatography mass spectrometry. J. Chromatogr., 565 (1991) 265-275.
A.P. Tinke, C.E.M. Heeremans, R.A.M. van der Hoeven, W.M.A. Niessen, J. van der Greef andN.M.M. Nibbering, Positively and negatively charged water cluster ions generated via thermosprayLC-MS. Rapid Commun. Mass Spectrom., 5 (1991) 188-191.
C. Giroud, T. van der Leer, R. van der Heijden, R. Verpoorte, C.E.M. Heeremans, W.M.A. Niessenand J. van der Greef, Thermospray liquid chromatography mass spectrometry analysis of thealkaloids from Cinchona in vitro cultures: identification and fate of 10-methoxytryptamine. PlantaMed., 57 (1991) 142-148.
P.S. Kokkonen, G.J. ten Hove, W.M.A. Niessen, U.R. Tjaden, G. van de Werken and J. van derGreef, Identification of intact glucosinolates using direct coupling of high-performance liquidchromatography with continuous-flow frit fast atom bombardment tandem mass spectrometry. Biol.
Mass Spectrom., 20 (1991) 259-267.
M.L.M. van de Poll, V. Venizelos, W.M.A. Niessen and J.H.N. Meerman, An unusual dearomatizedadduct formed by reaction of 4'-Fluoro-4-(acetylamino)biphenyl N-sulfate with deoxyadenosine.
Chem. Res. Toxicol., 4 (1991) 318-323.
C.E.M. Heeremans, R.A.M. van der Hoeven, W.M.A. Niessen, J. van der Greef and N.M.M.
Nibbering, Mechanisms of repeller induced effects in thermospray LC-MS. Org. Mass Spectrom., 26(1991) 519-527.
W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Strategies in developing interfaces for couplingliquid chromatography and mass spectrometry. J. Chromatogr., 554 (1991) 3-26.
A.P. Tinke, R.A.M. van der Hoeven, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Someaspects of peak broadening in particle-beam liquid chromatography mass spectrometry. J.
Chromatogr., 554 (1991) 119-124.
C.E.M. Heeremans, A.M. Stijnen, R.A.M. van der Hoeven, W.M.A. Niessen, M. Danhof and J. vander Greef, Thermospray liquid chromatography tandem mass spectrometry for identification of anheptabarbital metabolite and sample work-up artefacts. J. Chromatogr., 554 (1991) 205-214.
E.R. Verheij, U.R. Tjaden, W.M.A. Niessen and J. van der Greef, Pseudo-Electrochromatography /Mass Spectrometry: a New Alternative. J. Chromatogr., 554 (1991) 339-349.
M.S. Leloux, W.M.A. Niessen, R.A.M. van der Hoeven and J. van der Greef, The use of thermospray liquid chromatography mass spectrometry for the doping analysis of beta-blockingdrugs. Biol. Mass Spectrom., 20 (1991) 647-649.
G.J. Niemann, A. van der Kerk, W.M.A. Niessen and K. Versluis, Free and cell wall-boundphenolics and other constituents from healthy and fungus-infected carnation (Dianthus caryophyllusL.) stems. Physiol. Mol. Plant Pathol., 38 (1991) 417-432.
W.M.A. Niessen, R.A.M. van der Hoeven and J. van der Greef, On-line liquid chromatographythermospray mass spectrometry in the analysis of oligosaccharides. Rapid. Commun. MassSpectrom., 6 (1992) 197-202.
W.M.A. Niessen, R.A.M. van der Hoeven and J. van der Greef, Analysis of intact oligosaccharidesby liquid chromatography - mass spectrometry. Org. Mass Spectrom., 27 (1992) 341-342.
E. van Bakergem, R.A.M. van der Hoeven, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening ofdrugs in plasma. J. Chromatogr., 598 (1992) 189-194.
G.K. Poon, M. Jarman, R. McCague, J.H. Davies, C.E.M. Heeremans, W.M.A. Niessen and J. vander Greef, Identification of 4-hydroxyandrost-4-ene-3,17-dione metabolites in prostatic cancerpatients by liquid chromatography mass spectrometry. J. Chromatogr., 576 (1992) 235-244.
W.M.A. Niessen, R.A.M. van der Hoeven, J. van der Greef, H.A. Schols, G. Lucas-Lokhorst, A.G.J.
Voragen and C. Bruggink, High-Performance Anion-Exchange Chromatography Thermospray MassSpectrometry in the Analysis of Oligosaccharides. Rapid Commun. Mass Spectrom., 6 (1992) 474-478.
J. van der Greef and W.M.A. Niessen, Hyphenated methods in mass spectrometry. Int. J. MassSpectrom. Ion Processes, 116 (1992) 857-873.
A.P. Tinke, N.J. Reinhoud, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, On-lineisotachophoresis analyte focussing for improvement of detection limits in capillary electrophoresis-electrospray mass spectrometry. Rapid Commun. Mass Spectrom., 6 (1992) 560-563.
R.A.M. van der Hoeven, W.M.A. Niessen, H.A. Schols, C. Bruggink, A.G.J. Voragen and J. van derGreef, Analysis of sugar oligomers by on-line high-performance anion-exchange chromatographythermospray mass spectrometry. J. Chromatogr., 627 (1992) 63-73.
G.K. Poon, Y.C. Chui, M. Jarman, M.G. Rowlands, P.S. Kokkonen, W.M.A. Niessen and J. van derGreef, Investigation of conjugated metabolites of 4-hydroxyandrost-4-ene-3,17-dione in patientsurine by liquid chromatography atmospheric pressure ionization mass spectrometry. Drug Metab.
Dispos., 20 (1992) 941-947.
N.J. Reinhoud, A.P. Tinke, U.R. Tjaden, W.M.A. Niessen and J. van der Greef, Capillaryisotachophoretic analyte focusing for capillary electrophoresis with mass spectrometric detectionusing electrospray ionisation. J. Chromatogr., 627 (1992) 263-271 G.J. Niemann, J. Liem, A. van der Kerk-van Hoof and W.M.A. Niessen, Phytolexins,benzoxazinones, N-aroylanthranilates and N-aroulanalinines, from Fusarium-infected carnationstems. Phytochemistry, 31 (1992) 3761-3767.
A.M. Stijnen, C.E.M. Heeremans, C.F.A. van Bezooijen, W.M.A. Niessen and M. Danhof,Disposition of haptabarbital in the rat: identification of a new metabolite by tandem massspectrometry. J. Pharm. Pharmacol., 44 (1992) 907-.
R.A.M. van der Hoeven, A.P. Tinke, W.M.A. Niessen and J. van der Greef, Thermal surfaceionization of quaternary ammonium salts in particle-beam mass spectrometry. Rapid Commun. MassSpectrom., 7 (1993) 37-40.
W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Capillary electrophoresis mass spectrometry. J.
Chromatogr., 636 (1993) 3-19.
W.M.A. Niessen, C.C. McCarney, P.E.G. Moult, U.R. Tjaden and J. van der Greef, Liquidchromatography mass spectrometry for the identification of minor components in benzothiazole derivatives. J. Chromatogr., 647 (1993) 107-119.
A.P. Tinke, R.A.M. van der Hoeven, W.M.A. Niessen, J. van der Greef, J.-P. Vincken and H.A.
Schols, Electrospray mass spectrometry of neutral and acidic oligosaccharides: methylatedcyclodextrins and identification of unknowns derived from fruit material. J. Chromatogr., 647 (1993)279-287.
W.M.A. Niessen, R.A.M. van der Hoeven, J. van der Greef, H.A. Schols, A.G.J. Voragen and C.
Bruggink, Recent progress in high-performance anion-exchange chromatography thermospray massspectrometry of oligosaccharides. J. Chromatogr., 647 (1993) 319-327.
A.P. Tinke, R.A.M. van der Hoeven, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Newionization strategies in particle-beam liquid chromatography/mass spectrometry based on theprinciple of surface ionization. J. Chromatogr., 647 (1993) 63-72.
M. Hugener, A.P. Tinke, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Pseudo-electrochromatography negative-ion electrospray mass spectrometry of aromatic glucuronides andfood colors. J. Chromatogr., 647 (1993) 375-385.
R. Verpoorte and W.M.A. Niessen, Liquid chromatography coupled to mass spectrometry in theanalysis of alkaloids. Phytopath. Anal., 5 (1994) 217-232.
H.A. Schols, M. Mutter, A.G.J. Voragen, W.M.A. Niessen, R.A.M. van der Hoeven and J. van derGreef, The use of combined high-performance anion-exchange chromatography thermospray massspectrometry in the structural analysis of pectic oligosaccharides. Carbohydr. Res., 261 (1994) 335-342.
M.H. Lamoree, N.J. Reinhoud, U.R. Tjaden, W.M.A. Niessen and J. van der Greef, On-capillaryisotachophoresis for loadability enhancement in capillary zone electrophoresis-mass spectrometry of $-agonists. Biol. Mass Spectrom., 23 (1994) 339-345.
S.-Y. Fung, J. Brussee, R.A.M. van der Hoeven, W.M.A. Niessen, J.J.C. Scheffer and R. Verpoorte,Analysis of proposed aromatic precursors of hop bitter acids. J. Nat Prod., 57 (1994) 452-459.
S. Jespersen, W.M.A. Niessen, U.R. Tjaden, J. van der Greef, E. Litborn, U. Lindberg and J.
Roeraade, Attomole detection of proteins by matrix-assisted laser desorption/ionization massspectrometry with the use of picolitre vials. Rapid Commun. Mass Spectrom., 8 (1994) 581-584.
A.P. Tinke, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Hyperthermal surface ionization as anew interfacing approach in Liquid Chromatography/Mass Spectrometry. Anal. Chem., 66 (1994)3005-3012.
J.M. Greenberg, A. Kouchi, W.M.A. Niessen, H. Irth, J. van Paradijs, M. de Groot and W. Hermsen,Interstellar dust, chirality, comets and the origins of life: life from dead stars. J. Biol. Phys., 20(1994) 61-70.
S. Jespersen, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Quantitative bioanalysis in matrix-assisted laser desorption ionization/mass spectrometry. J. Mass Spectrom., 30 (1995) 357-364.
W.M.A. Niessen and A.P. Tinke, Liquid Chromatography - Mass Spectrometry, General principlesand instrumentation. J. Chromatogr. A, 703 (1995) 37-57.
V. Steinebach, B.W. Groen, S.S. Wijmenga, W.M.A. Niessen, J.A. Jongejan and J.A. Duine,Identification of topaquinone, as illustrated for pig kidney diamine oxidase and Escherichia coliamine oxidase. Anal. Biochem., 230 (1995) 159-166.
J.-P. Vincken, A.J.M. Wijsman, G. Beldman, W.M.A. Niessen and A.G.J. Voragen, Potatoxyloglucan is built from XXGG-type subunits. Carbohydr. Res., 288 (1996) 219.
J.-P. Vincken, G. Beldman, W.M.A. Niessen and A.G.J. Voragen, Degradation of apple fruitxyloglucan by endoglucanase. Carbohydr. Polym., 29 (1996) 75-85.
S. Jespersen, J.H.T.M. Ploemen, P.J. van Bladeren, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Identification of multiple target sites for a glutathione conjugate on Glutathione-S-Transferaseby Matrix-Assisted Laser Desorption Mass Spectrometry. J. Mass Spectrom., 31 (1996) 101.
J. Slobodník, A.C. Hogenboom, J.J. Vreuls, J.A. Rontree, B.L.M. van Baar, W.M.A. Niessen andU.A.Th. Brinkman, Trace-level determination of pesticide residues using on-line solid-phaseextraction/column liquid chromatography with atmospheric-pressure ionization mass spectrometricand tandem mass spectrometric detection. J. Chromatogr., 741 (1996) 59-74.
A.C. Hogenboom, J. Slobodnik, J.J. Vreuls, J.A. Rontree, B.L.M. van Baar, W.M.A. Niessen andU.A.Th. Brinkman, Single short column liquid chromatography with atmospheric-pressure chemicalionization - (tandem) mass spectrometric detection for trace environmental analysis.
Chromatographia, 42 (1996) 506-514 R.B. Geerdink, P.J. Berg, P.G.M. Kienhuis, W.M.A. Niessen and U.A.Th. Brinkman, Flow-injectionanalysis – thermospray tandem mass spectrometry of triazine herbicides and some of theirdegradation products in surface water. Int. J. Environ. Anal. Chem., 64 (1996) 265-278.
W.A. Minnaard, A.C. Hogenboom, U.K. Malmqvist, P. Manini, W.M.A. Niessen and U.A.Th.
Brinkman, Rapid target analysis by on-line single short column liquid chromatography thermospray-tandem mass spectrometry. Rapid Commun. Mass Spectrom., 10 (1996) 1569-1574.
A.C. Hogenboom, P. Speksnijder, R.J. Vreeken, W.M.A. Niessen and U.A.Th. Brinkman, Rapidtarget analysis of microcontaminants in water by on-line single-short column liquid chromatographycombined with atmospheric-pressure chemical ionization tandem mass spectrometry. J. Chromatogr.,777 (1997) 81-90.
A.C. Hogenboom, W.M.A. Niessen and U.A.Th. Brinkman, Single short column approach for theLC determination of organic microcontaminants in water using diode-array UV and massspectrometric detection, LC-GC Intern., 10 (1997) 669-678.
R.B. Geerdink, S. van Tol-Wildenburg, W.M.A. Niessen and U.ATh. Brinkman, Determination ofphenoxy acid herbicides from aqueous samples by improved clean-up on polymeric precolumns athigh pH, Analyst, 122 (1997) 889-893.
R.J. Dijkstra, B.L.M. van Baar, Ch.E. Kientz, W.M.A. Niessen and U.A.Th. Brinkman, An Eluent-Jet interface for Chemical Ionization Mass Spectrometry and Coupling of microcolumn LC withElectron Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom., 12 (1998) 5-10.
A.C. Hogenboom, W.M.A. Niessen and U.A.Th. Brinkman, Rapid target analysis ofmicrocontaminants in water by on-line single-short column liquid chromatography combined withatmospheric-pressure chemical ionization ion-trap mass spectrometry, J. Chromatogr. A, 794 (1998)201-210.
W.M.A. Niessen, Advances in instrumentation in LC–MS and related liquid-introduction techniques.
J. Chromatogr.A, 794 (1998) 407-435.
R.B. Geerdink, A. Attema, W.M.A. Niessen and U.ATh. Brinkman, Selective solid phase extractionprocedures for the determination of triazines and their degradation products in water, LC-GC Intern.,11 (1998) 361-372.
W.M.A. Niessen, Analysis of antibiotics by liquid chromatography – mass spectrometry (Review). J.
Chromatogr. A, 812 (1998) 53-76.
P. Manini, R. Andreoli, A. Mutti, E. Bergamaschi, I. Franchini and W.M.A. Niessen, Determinationof glucuronides of molecules of toxicological interest by liquid chromatography negative-ion massspectrometry with atmospheric-pressure chemical ionization. Chromatographia, 47 (1998) 659-666.
A.C. Hogenboom, R.J.C.A. Steen, W.M.A. Niessen and U.A.Th. Brinkman, Potential of short-column liquid chromatography with tandem mass spectrometric detection for the rapid study ofpesticide degradation. Chromatographia, 48 (1998) 475-480.
R. Andreoli, P. Manini, A. Mutti, E. Bergamaschi and W.M.A. Niessen, Determination of n-hexanemetabolites by LC–MS: I. 2,5-Hexanedione and other Phase-I metabolites in untreated and hydrolysed urine samples by atmospheric-pressure chemical ionization. Rapid Commun. MassSpectrom., 12 (1998) 1410-1416.
P. Manini, R. Andreoli, A. Mutti, E. Bergamaschi and W.M.A. Niessen, Determination of n-hexanemetabolites by LC–MS: II. Glucuronide-conjugated metabolites in untreated urine samples byelectrospray ionization. Rapid Commun. Mass Spectrom., 12 (1998) 1615-1624.
S. Jespersen, W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Basic matrices in the analysis ofnon-covalent complexes by matrix-assisted laser desorption/ionization mass spectrometry. J. MassSpectrom., 33 (1998) 1088-1093.
A.C. Hogenboom, W.M.A. Niessen, D. Little and U.A.Th. Brinkman, Accurate mass determinationfor the confirmation and identification of organic microcontaminants in surface water using on-linesolid-phase extraction liquid chromatography electrospray orthogonal-acceleration time-of-flightmass spectrometry. Rapid Commun. Mass Spectrom., 13 (1999) 125-133.
A.C. Hogenboom, W.M.A. Niessen and U.A.Th. Brinkman, On-line solid-phase extraction short-column liquid chromatography combined with tandem mass spectrometric scanning strategies for therapid study of the formation of degradation products of pesticides in surface water. J. Chromatogr. A,841 (1999) 33-44.
R. Andreoli, P. Manini, E. Bergamaschi, A. Mutti, I. Franchini and W.M.A. Niessen, Determinationof naphthalene metabolites in human urine by liquid chromatography mass spectrometry withelectrospray ionization. J. Chromatogr. A, 847 (1999) 9-17.
W.M.A. Niessen, State-of-the-art in Liquid Chromatography – Mass Spectrometry. J. Chromatogr.
A, 856 (1999) 179-197.
W.M.A. Niessen, LC–MS and CE–MS Strategies in Impurity Profiling. Chimia, 53 (1999) 478-483.
A.C. Hogenboom, M. Hofman, D.A. Jolly, W.M.A. Niessen and U.A.Th. Brinkman, On-line dual-precolumn-based trace enrichment for the determination of polar and acidic microcontaminants inriver water by liquid chromatography with diode array UV and tandem mass spectrometric detection.
J. Chromatogr. A, 885 (2000) 377-388.
P. Manini, R. Andreoli, S. Cavazzini, E. Bergamaschi, A. Mutti and W.M.A. Niessen, Liquidchromatography–electrospray tandem mass spectrometry of acidic monoamine metabolites. J.
Chromatogr. B, 744 (2000) 423-431.
A.C. Hogenboom, M.P. Hofman, S.J. Kok, W.M.A. Niessen and U.A.Th. Brinkman, Determinationof pesticides in vegetables using large-volume injection column liquid chromatography–electrospraytandem mass spectrometry. J. Chromatogr. A, 892 (2000) 379-390.
A.C. Hogenboom, W.M.A. Niessen and U.A.Th. Brinkman, Characterization of photodegradationproducts of alachlor in water by on-line solid-phase extraction liquid chromatography combined withtandem mass spectrometry and orthogonal-acceleration time-of-flight mass spectrometry. RapidCommun. Mass Spectrom., 14 (2000) 1914-1924.
W.M.A. Niessen: Quantitative Analysis by LC–MS. Reviews Anal. Chem., 19 (2000) 289-301.
P. Manini, R. Andreoli, E. Bergamaschi, G. de Palma, A. Mutti and W.M.A. Niessen, A new methodfor the analysis of styrene mercapturic acids by liquid chromatography–electrospray massspectrometry. Rapid Commun. Mass Spectrom., 14 (2000) 2055-2060.
W.M.A. Niessen, Structure elucidation by LC-MS. Foreword. Analusis, 28 (2000) 885-887.
R.B. Geerdink, W.M.A. Niessen and U.A.Th. Brinkman, Mass spectrometric confirmation criterionfor product-ion spectra generated in flow-injection analysis. Environmental application. J.
Chromatogr. A, 910 (2001) 291-300.
A.C. Hogenboom, W.M.A. Niessen and U.A.Th. Brinkman, The role of column liquidchromatography–mass spectrometry in environmental trace-level analysis. Determination and identification of pesticides in water. J. Sep Sci., 24 (2001) 331-354.
W.M.A. Niessen and U.A.Th. Brinkman, Foreword: Mass Spectrometry: Innovation andApplication. J. Chromatogr. A, 970 (2002) 1.
R.B. Geerdink, W.M.A. Niessen and U.A.Th. Brinkman, Review: Trace-level determination ofpesticides in water by means of liquid and gas chromatography. J. Chromatogr. A, 970 (2002) 65-93.
W.M.A. Niessen, J. Lin and G.C. Bondoux, Developing strategies for isolation of minor impuritieswith mass spectrometry-directed fractionation. J. Chromatogr. A, 970 (2002) 131-140.
P. Manini, R. Andreoli, D. Poli, G. De Palma, A. Mutti, W.M.A. Niessen, Liquid chromatography –electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat.
Rapid Commun. Mass Spectrom., 16 (2002) 2239-2248.
R. Andreoli, P. Manini, M. Corradi, A. Mutti and W.M.A. Niessen, Determination of patterns ofbiologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquidchromatography – atmospheric-pressure chemical ionization tandem mass spectrometry. RapidCommun. Mass Spectrom., 17 (2003) 637-645.
W.M.A Niessen, Progress in liquid chromatography - mass spectrometry instrumentation and itsimpact on high-throughput screening. J. Chromatogr. A, 1000 (2003) 413-436.
J. G. Krabbe, H. Lingeman, W. M. A. Niessen, and H. Irth, Ligand-exchange detection ofphosphorylated peptides using liquid chromatography electrospray mass spectrometry. Anal. Chem.,75 (2003) 6853-6860.
A.A.M. Stolker, W. Niesing, R. Fuchs, R.J. Vreeken, W.M.A. Niessen and U.A.Th. Brinkman,Liquid chromatography with triple-quadrupole and quadrupole-time-of-flight mass spectrometry forthe determination of micro-constituents - a comparison. Anal. Bioanal. Chem., 378 (2004)1754-1761.
R. Andreoli, P. Manini, E. Bergamaschi, A. Mutti and W.M.A. Niessen, Development of a simplifiedmethod for the simultaneous determination of retinol, alpha-tocopherol, and beta-carotene in serumby liquid chromatography-tandem mass spectrometry with atmospheric pressure chemical ionization.
Anal. Bioanal. Chem., 378 (2004) 987-994.
A.R. de Boer, T. Letzel, D.A. van Elswijk, H. Lingeman, W.M.A. Niessen and H. Irth, On-linecoupling of high-performance liquid chromatography to continuous-flow enzyme assay based onelectrospray ionization mass spectrometry. Anal. Chem., 76 (2004) 3155-3161.
M. Ibáñez, J.V. Sancho, Ó.J. Pozo, W.M.A. Niessen and F. Hernández, Use of quadrupoletime-of-flight mass spectrometry in the elucidation of unknown compounds present in environmentalwater. Rapid Commun. Mass Spectrom., 19 (2005) 169-178.
A. Leporati, D. Catellani, M. Suman, R. Andreoli, P. Manini and W.M.A. Niessen, Application ofliquid chromatography tandem mass spectrometry method to the analysis of water-soluble vitaminsin Italian pasta. Anal. Chim. Acta, 531 (2005) 87-95.
A.R. de Boer, B. Bruyneel, J.G. Krabbe, H. Lingeman, W. M.A. Niessen and H. Irth, Amicrofluidic-based enzymatic assay for bioactivity screening combined with capillary liquidchromatography and mass spectrometry, Lab Chip, 2005, 5(11), 1286-1292.
J.G. Krabbe, H. Lingeman, W.M.A. Niessen and H. Irth, Screening for metal ligands by liquidchromatography-ligand exchange-electrospray mass spectrometry, J. Chromatogr. A, 1093 (2005)36-46.
N. Neungchamnong, C.F. de Jong, B. Bruyneel, W.M.A. Niessen, H. Irth, and K. Ingkaninan, HPLCcoupled on-line to ESI-MS and a DPPH-based assay for the rapid identification of anti-oxidants in Butea Superba, Phytochem. Anal., 16 (2005) 422-428.
A.R. de Boer, J.M. Alcaide-Hidalgo, J.G. Krabbe, J. Kolkman, C.N. van Emde Boas, W.M.A.
Niessen, H. Lingeman, and H. Irth, High-temperature liquid chromatography coupled on-line to acontinuous-flow biochemical screening assay with electrospray ionization mass spectrometricdetection, Anal. Chem., 77 (2005) 7894-7900.
E. de Rijke, P. Out, W.M.A. Niessen, F. Ariese, C. Gooijer, and U.A.Th. Brinkman, Analyticalseparation and detection methods for flavonoids: an overview, J. Chromatogr. A, 1112 (2006) 31-63.
C.F. de Jong, R.J.E. Derks, B. Bruyneel, W.M.A. Niessen and H. Irth, High-performance liquidchromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitorsin natural extracts. J. Chromatogr. A, 1112 (2006) 303-310. J.S. Hoos, H. Sudergat, J.-P. Hoelck, M. Stahl, J.S.B. de Vlieger, W.M.A. Niessen, H. Lingeman,and H. Irth, Selective quantitative bioanalysis of proteins in biological fluids by on-line IAC–proteindigestion–LC–MS, J. Chromatogr. B, 830 (2006) 262.
W.M.A. Niessen, P. Manini and R. Andreoli, Matrix effects in quantitative pesticide analysis usingliquid chromatography-mass spectrometry, Mass Spectrom. Rev., 25 (2006) 881-899.
J.G. Krabbe, F. Gao, J. Li, J.E. Ahlskog, H. Lingeman, W.M.A. Niessen and H. Irth, Selectivedetection and identification of phosphorylated proteins by simultaneous ligand-exchangefluorescence detection and mass spectrometry, J. Chromatogr. A, 1130 (2006) 287-295.
O.J. Pozo, J.V. Sancho, M. Ibáñez, F. Hernández, and W.M.A. Niessen, Exploring the confirmationof organic micropollutants findinds in environmental samples by liquid chromatography tandemmass spectrometry: achievements and pitfalls, Trends Anal Chem., 25 (2006) 1030-1042.
S.M. van Liempd, J. Kool, W.M.A. Niessen, D.E. van Elswijk, H. Irth, and N.P.E. Vermeulen,On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derivedmetabolites of selective estrogen receptor modulators, Drug Metab. Dispos., 34 (2006) 1640-1649.
B. Bruyneel, S.J. Hoos, M. Smoluch, H. Lingeman, W.M.A. Niessen, and H. Irth, Trace analysis ofproteins using post-separation digestion and electrospray mass spectrometric identification of markerpeptides, Anal. Chem., 79 (2007) 1591-1598.
J.G. Krabbe, A.R. de Boer, G. van der Zwan, H. Lingeman, W.M.A. Niessen, and H. Irth, Metal-complex formation in continuous-flow ligand-exchange reactors studied by electrospray massspectrometry, J. Am. Soc. Mass Spectrom., 18 (2007) 707-713.
Boeken en boekhoofdstukken
W.M.A. Niessen and H. Poppe, Some aspects of coupling open-tubular liquid chromatography andmass spectrometry. In: H. Engelhardt and K.-P. Hupe (Ed.): Kopplungsverfahren in der HPLC, GitVerlag, Darmstadt, 1985, pp 55-57.
W.M.A. Niessen, Mass Spectrometric Detection in Open Tubular Liquid Chromatography.
Proefschrift, Universiteit van Amsterdam, 1986.
J. van der Greef, H. Lingeman, W.M.A. Niessen, and U.R. Tjaden, Future perspectives inbioanalysis. in: D.D. Breimer and P. Speiser (Ed.), Topics in Pharmaceutical Sciences 1987,Elsevier Science Publishers, Amsterdam, 1987, pp. 137-147.
W.M.A. Niessen and J. van der Greef, Liquid Chromatography - Mass Spectrometry. 1992, MarcelDekker Inc., New York, NY, USA.
J. van der Greef and W.M.A. Niessen, Hyphenated methods in mass spectrometry. in P.J.
Kistemaker and N.M.M. Nibbering (Ed.): Advances in Mass Spectrometry, Vol. 12, Proceedings ofthe 12th International Mass Spectrometry Conference, 1992, Elsevier Science Publishers,Amsterdam, The Netherlands, 857-873.
W.M.A. Niessen, U.R. Tjaden and J. van der Greef, Recent advances in the bioanalytical potential ofliquid chromatography mass spectrometry. in: E. Reid and I.D. Wilson (Ed.): Methodologicalsurveys in biochemistry and analysis, Royal Society of Chemistry, Cambridge, UK, 1992, p. 253-260.
W.M.A. Niessen, Liquid Chromatography (1) HPLC-MS. in: R. McCrae (Ed.), Encyclopedia ofAnalytical Sciences, (1995) Academic Press, London U.K., Vol. 5, pp. 2654-2661.
S. Jespersen, W.M.A. Niessen, U.R. Tjaden, J. van der Greef, E. Litborn, U. Lindberg and J.
Roeraade, Picolitre vials: a new sample handling technique for matrix-assisted laserdesorption/ionization mass spectrometry. in: A.L. Burlingame and S.A. Carr (Ed.), MassSpectrometry in the Biological Sciences, 1996, Humana Press, Totowa, NJ, USA, p. 217-226 W.M.A. Niessen, H.A. Schols, R.A.M. van der Hoeven, A.G.J. Voragen and J. van der Greef,Characterization of oligosaccharides derived plant cell wall polysaccharides by combined high-performance anion exchange chromatography thermospray mass spectrometry. in: J.R. Jackson andH. Linskens, Modern Methods of Plant Analysis, Vol. 17, Springer Verlag, Heidelberg. (1996) pp.
147-163.
W.M.A. Niessen, Developments in interface technology for combined liquid chromatography,capillary electrophoresis ans supercritical fluid chromatography - mass spectrometry. in: D. Barcelo(Ed): Applications of LC-MS in Environmental Chemistry, Elsevier Science Publishers, (1996) pp.
3-70.
W.M.A. Niessen, Vloeistofchromatografie – Massaspectrometrie, in: Chromatografie in de Praktijk,2: Vloeistofchromatografie (1997), Hoofdstuk 11.
W.M.A. Niessen, Analytical Mass Spectrometry, in: R. Kellner, J.-M. Mermet, M. Otto and M.
Widmer (Eds), Analytical Chemistry, , Ch. 9.4, 1998, Wiley-VCH, Weinheim, p. 603-639.
W.M.A. Niessen and R.D. Voyksner (Ed.), Current Practice of Liquid Chromatography – MassSpectrometry, J. Chromatogr. A, 794 (1998).
W.M.A. Niessen, Liquid Chromatography – Mass Spectrometry, Second Edition, Revised andExpanded, Chromatographic Science Series, Vol. 79, (1998), Marcel Dekker Inc., New York, NY,USA.
W.M.A. Niessen, Mass Spectrometry: MS-MS (+MSn). in: J. Lindon, G. Tranter and J. Holmes(Eds), Encyclopedia of Spectroscopy & Spectrometry, (1999), Academic Press Ltd, London, UK, p.
1404-1410.
W.M.A. Niessen, Mass Spectrometry: Atmospheric pressure ionization. in: J. Lindon, G. Tranterand J. Holmes (Eds), Encyclopedia of Spectroscopy & Spectrometry, (1999), Academic Press Ltd,London, UK, p. 18-24.
W.M.A. Niessen, Mass Spectrometry: Thermospray ionization. in: J. Lindon, G. Tranter and J.
Holmes (Eds), Encyclopedia of Spectroscopy & Spectrometry, (1999), Academic Press Ltd, London,UK, p. 2353-2360.
W.M.A. Niessen, Mass Spectrometry: Hyphenated techniques, Applications in MS. in: J. Lindon, G.
Tranter and J. Holmes (Eds), Encyclopedia of Spectroscopy & Spectrometry, (1999), AcademicPress Ltd, London, UK, p. 843-849.
W.M.A. Niessen, Mass Spectrometry: Chromatography MS, Methods. in: J. Lindon, G. Tranter andJ. Holmes (Eds), Encyclopedia of Spectroscopy & Spectrometry, (1999), Academic Press Ltd,London, UK, p. 293-300.
W.M.A. Niessen (Ed.), Current Practice in Gas Chromatography – Mass Spectrometry,Chromatographic Science Series, Vol. 86 (2001), Marcel Dekker Inc., New York, NY, USA.
W.M.A. Niessen, Organic Mass Spectrometry, in R. Kellner, J.-M. Mermet, M. Otto, M. Valcárceland H.M. Widmer, Analytical Chemistry, Second Edition, 2004, p. 823-864.
W.M.A. Niessen, Liquid Chromatography-Mass Spectrometry, in Encyclopedia of AnalyticalScience, Second Edition (Paul J. Worsfold, Alan Townshend and Colin F. Poole, eds.), Elsevier,Oxford, Vol. 5, 2005, pp. 213-221.
W.M.A. Niessen, Electrospray, in Encyclopedia of Analytical Science, Second Edition (Paul J.
Worsfold, Alan Townshend and Colin F. Poole, eds.), Elsevier, Oxford, Vol. 5, 2005, pp. 373-379.
W.M.A. Niessen, Volume 8: Hyphenated Methods (Volume Editor), in: R.M. Caprioli and M.L.
Gross, The Encyclopedia of Mass Spectrometry, Elsevier Oxford, 2006.
W.M.A. Niessen, Hyphenation – Principles, aims and general issues, in Volume 8: HyphenatedMethods (W.M.A. Niessen, Ed.) of the Encyclopedia of Mass Spectrometry (M.L. Gross, and R.M.
Caprioli, Eds.), (2006), Elsevier B.V., pages 1-13.
W.M.A. Niessen, Principles and instrumentation of MS-MS, in Volume 8: Hyphenated Methods(W.M.A. Niessen, Ed.) of the Encyclopedia of Mass Spectrometry (M.L. Gross, and R.M. Caprioli,Eds.), (2006), Elsevier B.V., pages 13-19.
W.M.A. Niessen, Data acquisition strategies for multiresidue analysis and screening, in Volume 8:Hyphenated Methods (W.M.A. Niessen, Ed.) of the Encyclopedia of Mass Spectrometry (M.L.
Gross, and R.M. Caprioli, Eds.), (2006), Elsevier B.V., pages 19-27 W.M.A. Niessen, High-resolution mass spectrometry and accurate-mass determination, in Volume 8:Hyphenated Methods (W.M.A. Niessen, Ed.) of the Encyclopedia of Mass Spectrometry (M.L.
Gross, and R.M. Caprioli, Ed.), (2006), Elsevier B.V., pages 27-25.
W.M.A. Niessen and B. Bruyneel, Microelectrospray and nanoelectrospray for LC-MS and CE-MS,in Volume 8: Hyphenated Methods (W.M.A. Niessen, Ed.) of the Encyclopedia of MassSpectrometry (M.L. Gross, and R.M. Caprioli, Ed.), (2006), Elsevier B.V., pages 55-60.
W.M.A. Niessen, Atmospheric pressure chemical ionization interfacing and ionization for LC-MS,in Volume 8: Hyphenated Methods (W.M.A. Niessen, Ed.) of the Encyclopedia of MassSpectrometry (M.L. Gross, and R.M. Caprioli, Ed.), (2006), Elsevier B.V., pages 73-84. W.M.A. Niessen, Information from atmospheric pressure ionization mass spectra, in Volume 8:Hyphenated Methods (W.M.A. Niessen, Ed.) of the Encyclopedia of Mass Spectrometry (M.L.
Gross, and R.M. Caprioli, Ed.), (2006), Elsevier B.V., pages 90-100.
W.M.A. Niessen, Liquid chromatographic aspects of LC-MS, in Volume 8: Hyphenated Methods(W.M.A. Niessen, Ed.) of the Encyclopedia of Mass Spectrometry (M.L. Gross, and R.M. Caprioli,Ed.), (2006), Elsevier B.V., pages 100-109.
G. Balizs and W.M.A. Niessen, Screening, identification and quantitation of antibiotics in animalproducts using LC-MS, in Volume 8: Hyphenated Methods (W.M.A. Niessen, Ed.) of theEncyclopedia of Mass Spectrometry (M.L. Gross, and R.M. Caprioli, Ed.), (2006), Elsevier B.V.,pages 695-707.
W.M.A. Niessen, Liquid Chromatography – Mass Spectrometry, Third Edition, ChromatographicScience Series, Vol. 97, (2006), Taylor & Francis Inc., Boca Raton, FL, USA.

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