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B. PHARMA- V SEMESTER
Rajiv Gandhi Proudyogiki Vihswavidyalay, Bhopal (M.P.)
PHARMACEUTICS- VI PY-501(COSMETIC TECHNOLOGY)
Fundamental of cosmetic science. Structure and functions of skin and hair. Formulation considerations, preparation, packaging and evaluation of the following categories of cosmetics- Face Preparation: Face powder, Compact powder, Talcum powder, Face packs and Masks.
Skin Preparation: Skin creams, Anti-wrinkle preparations, Barrier materials, Protective
creams and gels, Vanishing creams, Cold creams, Cleansing creams, all purpose creams, emollient, Anti-perspirant,/ deodorant, Moisturising and foundation formulation. Bleaching creams, Night and Massage creams, Hand creams, Protective skin tonics, Skin moisturizers, Sun-screen, Suntan, and anti-sun burn preparation. Shaving Preparation: Lather shaving stick, Lather shaving creams, Shaving foams, Shaving
Shampoo and Bath preparations: Clear liquid shampoos. Aerosol shampoos, dry
shampoos, Acid-balanced shampoos, Egg shampoos, Anti-dandruff Shampoos, Bath oils, Hair Preparations: Hair tonics, Hair conditioners, Hair lotions, Hair sprays, Hair dressings,
Hair setting lotions and creams, Hair dyes, Bleaches, Hair waiving, Hair straightners and Dentrifice: Tooth powders, Tooth pastes, Denture cleansers.
Foot Preparation: Foot powders, Foot sprays, Foot creams, Corn preparations and
Manicure Preparation: Nail polish, Nail lacquers and Nail bleaches.
Herbal Cosmetics: Cosmetics containing Aloe, Babul, Brahmi, Chandan, Cucumber, Haldi,
Jatamansi, Khus, Mehandi, Neem, Reetha, Shikakai, Tulsi, Arnica, Bhringraj and Volatile B. PHARMA- V SEMESTER
Cosmetic for babies.
Colored make-up preparations: Lipsticks, Rouge, Mascara, Eye make-up, Eye-liner,
LIST OF PRACTICALS:
1. Prepare, Pack and Evaluate Compact Powder. 4. Prepare and Evaluate Vanishing Cream. 6. Prepare and Evaluate Cleansing Cream. 7. Prepare and Evaluate Emollient Cream. 8. Prepare and Evaluate Sunscreen preparation. 9. Prepare and Evaluate After shave lotion. 10. Prepare and Evaluate Lather shaving cream. 11. Prepare and Evaluate Simple shampoo (Soap based). 12. Prepare and Evaluate Acid balanced shampoo. 14. Prepare and Evaluate Anti-dandruff Shampoo. 15. Prepare and Evaluate Hair conditioner. 18. Prepare, Pack and Evaluate Lipsticks. 19. Prepare, Pack and Evaluate Nail lacquer. 20. Prepare and submit Herbal preparations. (Atleast 5 different types) B. PHARMA- V SEMESTER
BOOKS RECOMMENDED:
1. M. S. Balsam & Edward Sagarin (Eds.), Cosmetic Science and Technology, Vol. 1-3, 2. Mac Chesney, J. C., Packaging of Cosmetic an Toiletries, Newness- Butterworth, 3. E.G., Thomssen, Modern Cosmetics, Universal Publishing Corporation, Bombay. 4. Jellinek, J.S. Formulation and Functions of Cosmetics, John Willey & Sons, New York. 5. R. K . Nema, K. S. Rathode, B.K. Dubey, Text Book of Cosmetics, CBS- Publishers & 6. Sunil Nanda, Arun Nanda & R.K. Khar, Cosmetic Technology, Birla publications Pvt. 7. B. M. Mithal and R.N. Saha, A handbook of cosmetics, Vallabh Prakashan, Delhi. 8. P.P. Sharma, Cosmetics- Formulation, Manufacturing & Quality control,Vandana 9. Hildo Butler (Ed.), Poucher’s Perfumes, Cosmetics & Soaps, Kluwer Academic 10. S.C. Bhata, Perfumes, soaps, Detergents and Cosmetics Vol. 1 & 2, CBS Publishers and B. PHARMA- V SEMESTER
PHARMACEUTICS- VII PY-502 (DISPENSING, COMMUNITY AND HOSPITAL
PHARMACY)
Dispensing Pharmacy:
Prescription, Handling of prescription, Sources of errors in prescription, Care required in dispensing prescriptions. Brief introduction of commonly used Latin terms in prescription. General Dispensing Procedures including labeling of dispensed products. Principles involved and procedures adopted in dispensing of typical prescriptions- Powders, Solutions, Mixtures, Emulsions, Lotions & Liniments. Physical, Chemical and Therapeutic incompatibilities, Incompatibility of common occurrence Basis of posology, Detection of over doses in prescription, knowledge of prophylactic and therapeutic doses with route of administration. Community Pharmacy:
Organisation and structure of retail and wholesale drug stores, Legal requirements for establishment and maintenance. Dispensing of proprietary products, Maintenance of records of retail and wholesaler, Patient counseling, Role of Pharmacist in community health care and A brief study of propritory products available in the market belonging to Chemotherapeutics, Vitamins, Anti-histaminics, expectorants and NSAID’S category. Hospital Pharmacy:
Organization and structure: Organization of a hospital pharmacy, responsibilities of a hospital pharmacist, pharmacy and therapeutic committee. Hospital Formulary: Contents, preparation and revision of hospital formulary. B. PHARMA- V SEMESTER
LIST OF PRACTICALS:
2. Prepare and Dispense Compound Powder. 3. Prepare and Dispense Powder containing small doses. 4. Prepare and Dispense Powder containing liquids. 5. Prepare and Dispense Powder containing liquefiable substances. 6. Prepare and Dispense Powder containing hygroscopic and deliquescent substances. 7. Prepare and Dispense Powder containing efflorescent materials. 8. Prepare and Dispense effervescent granules. 10. Prepare and Dispense Simple Mixture containing Soluble substances only. 11. Prepare and Dispense Mixture containing Diffusible solids. 12. Prepare and Dispense Mixture containing Indiffusible solids. 13. Prepare and Dispense Mixture containing Precipitate forming liquids. 14. Prepare and Dispense Mixture containing Slightly soluble liquids. 15. Prepare and Dispense Mixture containing Small doses of potent medicaments. 16. Prepare and Dispense prescription possessing Physical Incompability (Incomplete 17. Prepare and Dispense prescription possessing Physical Incompability (Precipitation). 18. Prepare and Dispense prescription possessing Physical Incompability (Separation of 19. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts 20. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts 21. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts 22. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts B. PHARMA- V SEMESTER
23. Prepare and Dispense prescription possessing Chemical Incompability (Soluble salicylates with acids-Tolerated Incompatability). 24. Prepare and Dispense prescription possessing Chemical Incompability (Soluble salicylates with acids-Adjust Incompatability). 25. Prepare and Dispense prescription possessing Chemical Incompability (Soluble benzoates 26. Prepare and Dispense prescription possessing Chemical Incompability (Soluble benzoates 27. Prepare and Dispense prescription possessing Chemical Incompability (Soluble 28. Prepare and Dispense prescription possessing Chemical Incompability (Soluble benzoates 29. Prepare and Dispense prescription possessing Chemical Incompability (Evolution of 30. Prepare and Dispense prescription possessing Chemical Incompability of emulsifying 31. Prepare and Dispense Emulsion containing Volatile oils. 32. Prepare and Dispense Emulsion containing Fixed oils. 33. Prepare and Dispense Emulsion containing Oleoresins. 34. Prepare and Dispense Calamine lotion. 35. Prepare and Dispense turpentine liniment. BOOKS RECOMMENDED:
1. Allwodd M. C. and Fell J. T., Text book of Hospital Pharmacy, Blackwell Scientific 2. Hassan W. E., Lea and Febiger, Philadelphia Hospital Pharmacy. 3. J.S. Qadry, R.K. Goyal & R.K. Parika, Merchant & Qadry’s a text book of Hospital Pharmacy, B.S. Shah Prakashan, Ahmedabad. 4. Pratibha Nand & R.K. Khar, Text Book of Hospital & Clinical Pharmacy, Birla B. PHARMA- V SEMESTER
5. S.J. Carter (Ed.), Cooper & Gunn’s Dispensing for Pharmaceutical Students, CBS Publishers & Distributors, New Delhi. 6. R.M. Mehta, Dispensing Pharmacy, Vallabh Prakashan, Delhi. 7. S.N. Sharma & N.K. Jain, the Concise Pharmaceutical Dispensing, Prakash B. Printers, 8. N.K. Jain & G.D. Gupta, Modern Dispensing Pharmacy, PharmaMed Press, Hyderabad. 9. E.W. Martin, Dispensing of Medications (Formerly Husa’s Pharmaceutical Dispensing) B. PHARMA- V SEMESTER
PHARMACEUTICAL CHEMISTRY -VI PY-503 (MEDICINAL CHEMISTRY- I)
Introduction to medicinal chemistry
 Principles of drug discovery: Basic principles of medicinal chemistry, physicochemical and steric aspects (optical, geometric and bioisosterism) of drug molecules and biological actions.  Receptors and drug action: Receptor theories, affinity, receptor and biologic  Drug metabolism: Phase I (biotransformation reactions), phase II (conjugation reactions), factor affecting drug metabolism.  Prodrugs and drug latentiation: Basic concepts, prodrug of functional groups, bioprecursor prodrugs, chemical delivery system. Classification and mode of action, uses, structure activity relationship including
physicochemical, steric aspects and resents advances in research of the following categories
of drugs:

Drugs affecting neurotransmission
 Drugs affecting cholinergic neurotransmission: Neurochemistry and stereochemistry of acetylcholine, acetylcholine mimetics-muscarinic agonists, acetlycholinesterase anatagonists, nicotinc antagonists-neuromuscular blocking agents, ganglionic blocking agents.  Drugs affecting adrenergic neurotransmission: Neurochemistry and stereochemistry of norepinephrine, sympathomimetic agents, sympatholytic agents, drugs affecting catecholamine biosynthesis, drugs affecting catecholamine storage and release, ergot alkaloids, xanthine bronchodilators  Drugs affecting serotonergic neurotransmission: Neurochemistry and stereochemistry of serotonin, 5-HT agonists, 5-HT antagonists.  Local anesthetics: Molecular mechanism of action, chemical aspects.  Drugs affecting immune systems
 Non-steroidal anti-inflammatory agents: Chemistry of chemical mediators of inflammation (prostaglandins, thromboxanes, prostacyclin and leukotrienes), antipyretic analgesics.  Antihistaminics and related antiallergics: Neurochemistry and stereochemistry of histamine, inhibitor of histamine release (mast cell stabilizers), inhibitors of released histamine, dual acting antihistaminics; H2 antagonists, H3 antagonists. B. PHARMA- V SEMESTER
LIST OF PRACTICALS:
(Minimum fifteen experiments should be performed in the semester. Student should aware with
safety parameters and handling of chemicals related to following experiments)

1. Synthesis and characteriazation of Tropenone from Maleyde aldehyde. 2. Synthesis and characteriazation of Scopolamine from Tropenol. 3. Synthesis and characterization of chlorzoxazone from 2-amino-4-chlorphenol. 4. Synthesis and characterization of Clemastine. 5. Synthesis and characterization of Tripelennamine. 6. Synthesis and characterization of Oxyphenbutazone. 7. Synthesis and characterization of trihexyl phenylidine. 8. Synthesis and characterization of Aspirin from salicylic acid. 9. Synthesis and characterization of Benzimadazole from benzyl chloride. 10. Synthesis and characterization of Sulphonilamide from Aniline. 11. Synthesis and characterization of Paracetamol from Para amino phenol. 12. Synthesis and characterization of Ibuprofen from isobutyl benzene. 13. Synthesis and characterization of Antipyrine 14. Synthesis and characterization of Phenyl benzoate. 15. Synthesis and characterization of Benzenilide. 16. Synthesis and characterization of Phenindione. 17. Synthesis and characterization of Methyl pyrazolone. B. PHARMA- V SEMESTER
BOOKS RECOMMENDED:
Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia. Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford. Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia. Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi. Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs. Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and B. PHARMA- V SEMESTER
PHARMACOGNOSY -III PY-504
General techniques of biosynthetic studies and basic metabolic pathways. Introduction to biosynthesis of secondary metabolites of pharmaceutical importance. A brief introduction of Radio – tracer techniques and utilization in biogenetic studies. Phytochemical Screening: Preparation of extracts and different tests performed for screening of extracts for the presence of alkaloids, saponins, steroidal compounds, flavanoids, anthraquinones, phenolics, amino acids, carbohydrates, fats etc. Concepts of stereoisomerisms Nature, distribution, classification, general methods of isolation and properties of alkaloids and terpenoids. Chemistry, biogenesis and pharmacological activity of atropine, reserpine, ephedrine, ergometrine, strychnine, quinine, morphine, digitoxin, sennosides, diosgenin, sarsapogenin, menthol, citral, taxol, rutin and artemisine. Systematic pharmacognostical study of alkoloidal drugs like; Tobacco, Belladona, Hyoscyamus, Datura, Coca, Withania, Cinchona, Ipecac, Opium, Ergot, Rauwolfia, Vinca, Nuxvomica, Physostigma, Pilocarpus, Veretrum, Kurchi, Ephedra, Solanam, Tea, Colchicum, coffeae, aconite LIST OF PRACTICALS:
1. Identify Colchicum, Ipecac and Vinca leaves morphologically. 2. Identify Aconite, Hyoscyamus and Withania leaves morphologically. 3. Perform morphological, microscopic and chemical evaluation of Tobacco. 4. Perform morphological, microscopic and chemical evaluation of Withania. 5. Perform morphological, microscopic and chemical evaluation of Cinchona bark. 6. Perform morphological, microscopic and chemical evaluation of Rauwolfia root. 7. Perform morphological, microscopic and chemical evaluation of Nux vomica seeds. B. PHARMA- V SEMESTER
8. Perform morphological, microscopic and chemical evaluation of Ephedra. 9. Perform morphological, microscopic and chemical evaluation of Kurchi bark. 13. Isolate alkaloids from nux vomica seeds. 15. Perform morphological characterization like type of stomata and calculate the stomatal index, vein islets, vein termination numbers, microscopic and chemical evaluation of 16. To identify and evaluate the given sample of Colchicum corm by morphological, 17. To identify the given sample of powdered crude drug by various phytochemical tests. BOOKS RECOMMENDED
1. Trease, G.E. and Evans, W.C., Pharmacognosy, Bailliere Tindall, Eastbourne, U.K. 2. Tayler, V.C., Brady, L.R. and Robers, J.E., Pharmacognosy, Lea and Febiger, Philadelphia. 3. Shah, C.S. and Quadry, J.S., A text book of Pharmacognosy, B.S. Shah Publishers, 4. Kokate, C.K., Purohit, A.P. and Gokhale, S.B., Pharmacognosy, Nirali Prakashan, Pune. 5. Indian Pharmacopoeia, Ministry of Health and Family Welfare, Govt. of India, New Delhi. Wallis, T.E., Text Book of Pharmacognosy, Jand A Churchill Limited, London B. PHARMA- V SEMESTER
PHARMACOLOGY-II PY-505
Pathophysiology of CNS diseases and pharmacology of drugs used to treat them
3) Hypnotics, sedatives, antianxiety agents, and centrally acting muscle relaxants. 7) Drugs used in neurodegenerative diseases Pharmacology of drugs acting on gastrointestinal tract
1) Antacids, antisecretory and antiulcer drugs B. PHARMA- V SEMESTER
LIST OF PRACTICALS
1) Bioassay for acetylcholine/histamine using isolated organ preparations (rat ileum/rat duodenum/rat colon/rat fundus/guinea pig ileum/guinea pig tracheal chain a) Matching bioassay or Bracketing bioassay b) Interpolation bioassay or graphical bioassay 2) Study the CNS depressants using cornea and pinna reflex test. 3) Study CNS stimulants by evaluation of locomotor activity (Actophotometer) 4) Study Central muscle relaxants using Rota rod apparatus 5) Study lenticular opacity produced by opioid analgesics in rodents. 6) Study anticonvulant effect of some drugs using maximum electroshock method and 7) Study antianxiety effect of some drugs using elevated plus maze test or social interaction test or novelty suppressed feeding test in rodents. 8) Evaluate hypnotic activity of a drug by employing potentiation of thiopental induced 9) Study antipsychotic effect of some drugs using catalepsy test or inhibition of Study intravenous anesthetics using righting reflex test. BOOKS RECOMMENDED
1) Herfindal, E.T., Gourley, D.R., (eds.) (2000) Textbook of therapeutics Drug and disease management. 7th ed. Baltimore: Lippincott Williams and Wilkins 2) Hardmen, J.G., Limbird, L.E., Gilman A.,G., (eds.) (2001) Goodman and Gilman’s The pharmacological basis of therapeutics. 10th ed. USA: The McGraw Hill Companies 3) Kumar, V., Abbas, A.K., Fausto, N., (eds.) (2004) Robbins and Cotran Pathologic basis of disease. 7th ed. Pennsylvania: Saunders B. PHARMA- V SEMESTER
4) Barar, F.S.K., (2000) Essentials of therapeutics. New Delhi: S. Chand and Company (P) 5) Satoskar, R.S., Bhandarkar, S.D., Rege, N.N., (2007) Pharmacology and Pharmacotherapeutics. 12th ed. Mumbai: Popular Prakashan 6) Seth, S.D., (ed.) (2005) Textbook of Pharmacology. 2nd ed. New Delhi. Elsevier 7) Tripathi, K.D. (1999) Essentials of medical pharmacology. 4th ed. New Delhi: Jaypee 8) Mycek M.J., Haney, R.A., Champe, P.C. (2000) Lippincott’s illustrated reviews: Pharmacology. 2nd ed. Baltimore: Lippincott Williams and Wilkins. 9) Rang, H.P., et al. (eds.) (2003) Pharmacology. 5th ed. Philadelphia: Elsevier 10) Katzung, B.G., (2004) Basic and clinical pharmacology. 9th ed. USA: The McGraw Hil 11) McKim, W.A., (2006) Drugs and Behavior: An Introduction to Behavioral Pharmacology. London: Prentice Hall. Rajiv Gandhi Proudyogiki Vishwavidalaya, Bhopal (M.P.)
B. PHARMA-VI SEMESTER (Modified on 03/09/12)
Pharmaceutical Industrial Management PY-601
Status of pharmaceutical industries in India.
Project formulation, evaluation and implementation.
Pharmaceutical Factory Planning and layouts, preparation of flow diagrams, technical
data sheets.
Pharmaceutical Management
Concepts on Management, Principles of Management, Administrative and Operative Management Enterpreneurship Development.
Material management: Basic principles of Material Management, Purchase, Store and
Inventory control.
Pharmaceutical Production Management :

Different aspects of Production Management , Performance Evaluation Technique, flow-process, know how process and maintainence.
Accountancy: Principles of accountancy, Journal entries and ledger posting, preparation
of trial balance, cash book, bank reconciliation statement, rectification of errors, profits
and loss account, balance sheet, purchase, keeping and pricing of stocks, treatment of
cheques, bill of exchange, promissory notes and hundies, documentary bills.
Pharmaceutical Economics:

Principles of economics with special reference to the laws of demands and supply, demand schedule, demand curves, general principles of insurance and inland and foreign
trade, procedure of exporting and importing goods.
Pharmaceutical Marketing: Functions, wholesale, retail, and mail order business ,market
research.
Pharmaceutical Salesmanship:
Principles of sales promotion, advertising, and ethics of Sales, merchandising, Window
display and literature detailing.
BOOKS RECOMMENDED:
1. Shukla, S. M., Advanced Accountancy, Mahershwari Sahitya Bhawan, Agra. 2. Gupta, R. L., Advanced Accountancy, Vol. I and II, Sultanchand & Company, New Delhi. 3. Kotler, P., Marketing Management, Prentice Hall of India Limited. 4. Stanton, W. J., Fundamentals of Marketing Tata McGraw Hill Limited, New Delhi. 5. Buskir K. and Richard H., Principles of Marketing – The Management View, Hold Rinehard and Winston Incorporated, New York. 6. Sherlekar, S. R., Marketing Management, Himalaya Publishing House, New Delhi. 7. Mote,V. L., Paul, S. and Gupta, G. S., Managerial Economics Concepts and Cases, Pharmaceutical Analysis II - PY 602
The theoretical aspects, basic instrumentation, elements of interpretation of spectra and pharmaceutical application of the following analytical techniques – 1. Chromatography: Paper Chromatography TLC, GLC, HPTLC and HPLC. 2. Ultraviolet and visible spectrophotometry: Beer-lambart law, electronic transitions, instrumentation, methods, chemical derivatisation, structural analysis, applications. 3. Infra red spectrophotometry & FT-IR: Introduction, Theory, instrumentation, interpretation of spectra, its advantages and applications in structure elucidation. 4. Fluorimetry. 5. Mass Spectroscopy: Introduction, ionization techniques, mass analyzers, fragmentation rules, instrumentation, the mass spectrum & its applications. 6. NMR Spectroscopy: Introduction, continous-wave (CW) NMR spectrometry, pulsed fourier transform spectrometry, chemical shift, spin coupling, spin decoupling & its applications. 7. Atomic Absorption. 8. X- Ray Diffraction. 9. Flame Photometry. 10. Immunoassay techniques: Enzymes & radioimmunoassay techniques, theory, BOOKS RECOMMENDED:
1. Svehla, G. Vogel’s Text Book of Micro and Semi Micro Qualitative Inorganic 2. Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical Chemistry, The Athlone Press of the University of London. 3. Chatten, L.G., Text Book of Pharmaceutical Chemistry, Marcel Dekker, New 4. Connors, K,.A., A Text Book of Pharmaceutical Analysis, Wiley Interscience, 5. Higuchi, J. and Hansen E.B., Pharmaceutical Analysis, Interscience Publisher 6. Silverstein,R.M., Bassier, G.C., and Morril,T.C., Spectrophotometric Identification of Organic Compounds, John Wiley and Sons Inc. 7. Willard, Merritt and Settle, Instrumental Methods of Chemical Analysis,CBS 8. Ewing, G.W., Instrumental Methods of Chemical Analysis,.

LIST OF PRACTICALS :

1. Determination of solvent cut off value of different solvents. 2. Study of effect of various solvents on spectral features of any drug. 3. Perform the quantitative spectrophotometric estimation of drug by single 4. Perform the quantitative spectrophotometric estimation of drug by 5. Perform the quantitative spectrophotometric estimation of drug by 6. Simultaneous quantitative spectrophotometric estimation of two drugs by 7. Simultaneous quantitative spectrophotometric estimation of two drugs by 8. Simultaneous quantitative spectrophotometric estimation of two drugs by 9. To determine the tablet content of norfloxacin by hydrotrophy. 11. Quantitative estimation of alprazolam (Any drug) by RP-HPLC. 12. Simultaneous quantitative estimation of torsemide and spironolactone 13. Acid and alkaline stress degradation study of any drug. 14. Photo and thermal stress degradation study of any drug. 15. Oxidative stress degradation study of any drug. PHARMACEUTICAL CHEMISTRY – VII PY-603 (MEDICINAL CHEMISTRY-II)
( I ) Classification and mode of action, uses, structure activity relationship including
physicochemical, steric aspects and recent advances in research of the following
categories of drugs:

(A) Drug Acting on CNS
• General Anesthetics: Stages of Anesthesia , Pharmacokinetic Principles, • Hypnotics and Sedatives : Testing and developments of new Hypnotics. • Antiscizure agents: Drugs effective against partial and generalized tonic- • Opiod Analgesics : Endogenous opioid peptides and their physiologic functions, Neurobiology of drug abuse and addiction. • Antiparkinsonian and Spasmolytic agents : Pharmacotherpy of Parkinsons • Hallucinogens, Stimulants, and related drugs of Abuse. • Psychopharmacological Agents: Antipsychotic agents, Antidepressants, (B) Drug Acting on GIT :
(C) Drug Acting on Hormonal System:
• Insulin and oral Hypoglycemic agents: Etiology of Diabetes, Biochemistry and Pathogenesis of Diabetes, Production of Insulin. • Adrenocorticoids: Mechanism of steroid Hormone action, Development of • Sex Hormones: Male sex Hormones, Female sex Hormones. • Thyroid and Antithyroid agents : Biochemistry and Physiology of Thyroid Hormones, Biosynthesis of Thyroid Hormones.
(D) Vitamins

( II ) Principles of Drug Design (Theoretical Aspects). Scientific Aspects of Drug
Discovery, Preclinical Development, Mechanism based Approaches (Computer
Aided Drug Design and Molecular Modeling)

BOOKS RECOMMENDED:
Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co., Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi. Patrick, G., An Introduction to Medicinal Chemistry, Scientific Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs. Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and LIST OF PRACTICALS :
1. Synthesis and Characterization of Methylphenobarbital from Urea. 2. Synthesis and Characterization of Barbital from Urea. 3. Synthesis and Characterization of Nikethamide from Nicotinic acid. 4. Synthesis and Characterization of Pantaprazol. 5. Synthesis and Characterization of Diclofenamide. 6. Synthesis and Characterization of Phenobarbitone. 7. Synthesis and Characterization of Phenothiazine. 8. Synthesis and Characterization of Furosemide from 2,4 dichloro-benzoic acid. 9. Synthesis and Characterization of Levodopa from Vanillin. 10. Synthesis and Characterization of Sulfalene from p-aminobenzene sulphonyl 11. Synthesis and Characterization of Thioridazine. 12. Synthesis and Characterization of Chlorpromazine. 13. Synthesis and Characterization of Benorilate. 14. Synthesis and Characterization of Parbanic acid. 15. Estimation of Na+, K+, Ca++ ions using flame photometry. 16. To perform the QSAR Analysis by Free Wilson Approach. 17. To determine the regression coefficients for a series by using Hansch and Free 18. To determine the correlation between physiochemical properties and biological activity for a series by using Hansch analysis. PHARMACOGNOSY – IV (PY 604)

General introduction classification and brief description of different chromatographic
techniques with detailed emphasis on application of paper chromatography, column
chromatography, TLC, HPLC and HPTLC in the evaluation of herbal drugs.
Historical development of plant tissue culture technique, types of culture, nutritional
requirements, surface sterilization of explants, growth and maintenance. Application of
PTC in development of phytoconstituents.
An introduction of marine pharmacognosy and novel agents from marine sources like
cardiovascular active substances, cytotoxic, antimicrobial, antibiotic, anti-inflammatory,
antispasmodic agents, marine toxin etc.
Herbs as health food, cosmeceuticals.
An introduction to cultivation and utilization of aromatic plants with special reference to
sandalwood oil, menthe oil, eucalyptus oil, lemon grass oil, clove oil.
Production and analysis of phytoconstituents of pharmaceutical importance like quinine,
strychnine, atropine, morphine podophyllotoxin, papain, vincristine, ephedrine and
Tannic acid, Spectral analysis of herbal drugs with emphasis on application of UV, IR,
NMR, mass.
Natural dyes, Immunomodulators and Adaptogents.

LIST OF PRACTICAL:

1. To perform chromatography of amino acids 2. To perform paper chromatography of sugars 4. To perform TLC of extract of rauwolfi, datura 5. To perform TLC of volatile oils i.e. eucalyptus oil, menthe oil 6. To identify the presence of eugenol in clove oil by TLC 7. To determine volatile oil content of eucalyptus leaf 8. To determine volatile oil content of fennel fruits 9. To isolate ammonium glycyrrhizinate from glycyrrhiza 11. To extract tannic acid from myrobalan 12. To perform column chromatography a natural dye. BOOKS RECOMMENDED:
1. Trease, G.E.and Evans, W.C., Pharmacognosy, Baillierc, Tindall, Eastbourne, 2. Tayler, V.E., Brady, L.R. and Robers, J.E., Pharmacognosy Lea and Febiger, Philadelphia 3. Kokate, C.K., Purohit, A.P. and Gokhale, S.B., Pharmacognosy Nirali Prakashan, 4. C.R Atal and B.M. Kapoor, Cultivation & Utilization of Aromatic Plants, Council of Scientific Industrial Research (CSIR) New Delhi. Pharmacology-III (PY 605)

Pathophysiology of diseases of cardiovascular system and pharmacology of drugs

used for their treatment
Pharmacology of drugs acting on hematopoietic system
b) Drugs affecting coagulation, bleeding and thrombosis Pharmacology of drugs acting on urinary system
Pathophysiology of diseases of endocrine system and pharmacology of drugs used
for their treatment
b) Thyroid hormones and antithyroid drugs c) Insulin, oral hypoglycemic agents and glucagons e) Androgens and drugs for erectile dysfunction f) Estrogens, progestins and contraceptives List of Practicals
1. Determine the strength of given sample (acetyl choline/ histamine) by three point bioassay method using isolated organ preparation (rat ileum/ rat duodenum/ rat colon/ 2. Determine the strength of given sample (acetyl choline/ histamine) by four point bioassay method using isolated organ preparation (rat ileum/ rat duodenum/ rat colon/ 3. Record the concentration response curve of oxytocin using rat uterus preparation. 4. Determine the sympatholytic activity of given drug sample using isolated guinea pig 5. Compare the diuretic/saluretic activity of different drugs in rats. 6. Determine the effect of anticoagulants by subaqueous tail bleeding time method in 7. Study the effect of oral hypoglycemic agents in diabetic rodents. 8. Study the effect of thyroid hormones on the tensile strength of connective tissues in 9. Study the effect of growth hormone on the weight gain in female rats.
BOOKS RECOMMENDED
1) Herfindal, E.T., Gourley, D.R., (eds.) (2000) Textbook of therapeutics Drug and
disease management. 7th ed. Baltimore: Lippincott Williams and Wilkins 2) Hardmen, J.G., Limbird, L.E., Gilman A.,G., (eds.) (2001) Goodman and Gilman’s The pharmacological basis of therapeutics. 10th ed. USA: The McGraw Hill Companies 3) Kumar, V., Abbas, A.K., Fausto, N., (eds.) (2004) Robbins and Cotran Pathologic basis of disease. 7th ed. Pennsylvania: Saunders 4) Barar, F.S.K., (2000) Essentials of therapeutics. New Delhi: S. Chand and Company 5) Satoskar, R.S., Bhandarkar, S.D., Rege, N.N., (2007) Pharmacology and Pharmacotherapeutics. 12th ed. Mumbai: Popular Prakashan 6) Seth, S.D., (ed.) (2005) Textbook of Pharmacology. 2nd ed. New Delhi. Elsevier 7) Tripathi, K.D. (1999) Essentials of medical pharmacology. 4th ed. New Delhi: Jaypee 8) Rang, H.P., et al. (eds.) (2003) Pharmacology. 5th ed. Philadelphia: Elsevier 9) Katzung, B.G., (2004) Basic and clinical pharmacology. 9th ed. USA: The McGraw 10) Pillai, K.K., (2009) Experimental Pharmacology. New Delhi, CBS Publishers and 11) Kulkarni, S.K., (2005) Handbook of Experimental Pharmacology. New Delhi, 12) Vogel, H.G., (ed.) (2002) Drug Discovery and Evaluation. Pharmacological Assays. 2nd Ed. Heidelberg, Germany, Springer-Verlag.

Source: http://www.vns.ac.in/vnsitpdf/Syllabus%20V-VI-ip.pdf

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