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M e l a n o c e u t i c a l S k i n B r i g h t e n i n g s y s t e m ALL BRIGHT AND EVEN For all over face and body brightening This skin brightening and lightening face and body cream is ideal for use all over the body. Can be used on the face, neck, elbows, dark knuckles or hands, in between thighs, knee’s, etc. Contains NO irritating ingredients such as alpha hydroxy acids, therefore can be used on sensitive skins or areas. A unique non-prescription strength skin brightening formulation containing ingredients offering a dual purpose
of being both an antioxidant and anti inflammatory which are proven to slow down melanogenesis (the formation
of melanin). Excellent for all types of hyperpigmentation such as age spots, sun spots, natural and unnatural skin
darkening due either from environmental or other damage. Treats pigmented and ageing skin simultaneously.


Active ingredients
Kojic Acid Dipalmitate
Arbutin
Magnesium Ascorbyl Phosphate
White Liquorice
Tetrahydrocurcuminoids
Glutathione
Melatonin
Superoxide Dismutase


Benefits:
Kojic acid (C6 H6 04), and its gentle dipalmitate ester, and produced in an aerobic process by a variety of micro-organisms from
a wide range of organic compounds. Kojic acid is believed to inactivate tyrosinase, and thereby brighten the skin, by chelating its vital copper ion.This differs from the way Hydroquinone is believed to inhibit tyrosinase, via competition with DOPA and its receptor site and tyrosinase.  Arbutin has been used traditionally in Japan as a skin-lightening agent. Its depigmenting mechanism is thought to act by
reversibly suppressing melanosomal tyrosinase activity rather than inhibiting the expression and production of tyrosinase. It also acts by inhibiting 5,6-dihydroxyindole-2-carboxylic acid (DHICA) polymerase; the hydrolyzation of the glycosidic bond then results in
hydroquinone release in a controlled manner. Tyrosinase is the rate-limiting enzyme that controls melanin production and is a unique
product of melanocytes. Consequently, agents that inhibit tyrosinase activity, which is a major regulatory step in melanogenesis, prevent
the synthesis of the pigment melanin and are therefore considered viable candidates as cosmetic skin-whitening ingredients. Found in the
leaves of pear trees and certain plants such as wheat and bearberry, and in lower quantities in cranberry and blueberry leaves Arbutin is a
naturally occurring.
Topical anti-oxidants, such as Vitamin C and its derivatives, have been shown clinically to possess brightening and lightening,
and skin soothing properties. This Vitamin C is called Magnesium Ascorbyl Phosphate (MAP).


White Licorice root extract has been used in Europe since prehistoric times, documented since the ancient Greeks, for its anti-
inflammatory and antimicrobial activity. Phytochemists and biochemists have been working for decades elucidating the structure of the chemicals involved and mechanisms of action. In the case of the root of Glycyrrhiza glabra this is not a single chemical that benefits the skin, but rather a combination of many chemicals. For this reason, Glyzyrhizinic acid, a chemical found in liquorice root, has been shown
to have pro-interferon and antiviral activity and is mostly used widely for skin lightening and atopic dermatitis. We use a concentration of
2% White Licorice
for best results.
Purified curcuminoids from tumeric (Curcuma longa), strong yellow in color, are modified chemically to increase its biological availability and to turn them white, making them more suitable for use in skin care products. Curcuminoids extracted from the rhizomes of
Curcuma longa (turmeric) have great antioxidant and anti-inflammatory properties that make them almost ideal ingredients for skin care.
Their molecular structure is the reason for the potent antioxidant properties they possess, but because of their low solubility and poor
bio-availability, very high concentrations are required to obtain the desired effects. Also, curcuminoids strong yellow color makes it
difficult to employ in high concentrations in cosmetic formulas. Scientists realized that the small amounts that were absorbed and used,
were eventually converted by the body into a much better chemical, tetrahydrocurcuminoids (THCs), so they decided to do the chemical
conversion (hydrogenation) in the laboratory, before applying it to the skin. Thus the yellow, low bio-availability curcuminoids are
converted in the lab into the colorless, highly soluble THCs. 1% concentration of Tetrahydrocurcuminoids (THC’s) keep the superior
antioxidant and anti-inflammatory properties of curcuminoids, but are easier to use in skin care products. Used in skin lightening and
brightening, it is beneficial to combine with other actives helpful in preventing damage to your skin by Ultra Violet Radiation.
Contact: 076 937 6388 or info@scinderm.co.za www.scinderm.co.za M e l a n o c e u t i c a l S k i n B r i g h t e n i n g s y s t e m L-Glutathione (a.k.a. gamma-L-Glutamyl-L-cysteinyl-glycine) is a tripeptide composed of the amino acids L-glutamine, L
-cysteine and glycine. Glutathione is a crucial element in the antioxidant defense system of the cell, together with superoxide
dismutase, catalase, alpha-D-tocopherol (vitamin E), ascorbic acid (vitamin C), etc. All of these antioxidants are required to defend
the cell (and the skin) from the powerful, destructive, oxidants formed during the course of metabolism, such as superoxide,
hydrogen peroxide, peroxyl oxides and hydroxyl radicals. The role of glutathione is fundamental, and impairment of the
glutathione system results in damage to the cell membrane and death of the cells. L-glutathione is part of the natural
armamentarium our body has to protect our skin from the reactive oxygen species that attack our skin on a continuous basis and
that are largely responsible for photoaging. The problem is that there are never enough of these endogenous warriors to go
around, especially not after some time in the sun or in a polluted city. But having gluthatione around protects ascorbic acid
(vitamin C), required for the synthesis of collagen and other skin constituents. For many reasons, it is a good idea to supplement
endogenous glutathione with some applied topically. Glutathione, like ascorbic acid, is water soluble, a good counterpart to
another antioxidant, Vitamin E, which is liposoluble. It is worth noting that the lightening activity on skin shown by
hydrocoumarins and beta-tocopherol is through the induction of the synthesis of glutathione. It has been shown that the
presence of glutathione can inhibit cell death induced by hydrogen peroxide, a powerful oxidant formed during UV irradiation.
Glutathione is lower in photoaged and normally aged skin. Although skin ageing is clearly a multifactorial process, data indicate
that the concentration of intracellular glutathione is very important and that depletion of this concentration may play a
significant role in the progression of cellular ageing in human skin.
Melatonin is secreted by the pineal gland in response to sun light, it has been shown to decrease accumulation of melanin.
Topical use of synthetic melatonin appears to be beneficial to the skin in many ways. Used in conjunction with magnesium
ascorbyl phosphate (MAP), melatonin improves skin elasticity. It may also help decrease the effect of sunlight radiation on the
skin and improve skin texture especially photoaged or damaged skins.
In our cells, we have our own Super Oxide Dismutase (SODs), but we can protect our skin by supplementing them with
topically applied SOD. The size of the SOD used in skin care varies between 10,000 and 30,000 molecular weight, relatively small
for an enzyme but large enough to be excluded from live cells. The fact that SOD is unlikely to enter live cells is not a problem.
Lipid peroxidation occurs everywhere in the skin, not just in the live cells. The role of SOD is to eliminate the free radicals
resulting from lipid peroxidation and to prevent the chain reactions that would eventually reach deeply into the skin, and topical
application of SOD will certainly help to achieve this aim. Superoxide radicals (free radicals) are formed in a number of metabolic
reactions, including lipid peroxidation initiated by light or metal ions. This process is the cause of rancidity of oils, but it also
happens in live tissues and may be a cause of cancer, inflammatory diseases, atherosclerosis, aging, and others. One of the
reasons that superoxide radicals are so dangerous is because they start chain reactions where more and more free radicals are
formed, reacting with all cell constituents and wreaking havoc wherever they go. In the human body, the main chain breaking
antioxidants are the water soluble Superoxide Dismutase (SOD) and the lipid soluble alpha-D-Tocopherol (vitamin E). SOD is a
particularly stable enzyme that converts the destructive superoxide radical into a less dangerous form, hydrogen peroxide (which
will, in turn, be converted into water and normal oxygen by the enzyme catalase).

Complete Ingredient Listing:

Water, Jojoba (Simmondsia Chinensis) Seed Oil, Sorbitol, Butylene Glycol, Cetyl Alcohol, Glyceryl Stearate, Kojic Acid Dipalmitate, PEG-100
Stearate, Stearyl Alcohol, Sesame (Sesamum Indicum) Seed Oil, Sweet Almond (Prunus Amygdalus Dulcis) Oil, Avocado (Persea Gratissima) Oil,
Arbutin, Magnesium Ascorbyl Phosphate, Sodium Hyaluronate, Liquorice (Glycyrrhiza Glabra) Extract, Tetrahydrocurcuminoids, Glutathione,
Melatonin, Superoxide Dismutase, Polysorbate 20, Citric Acid, Dimethicone, Carbomer, Triethanolamine, Diazolidinyl Urea, Phenoxyethanol

Dosage and Administration:
For best results, use twice a day (morning and evening) on a clean skin. Apply a generous amount directly to the desired area by gently
rubbing in a circular motion until completely absorbed into the skin. Allow to dry completely before applying any other products.
Continued use maintains the look as desired. Use Scinderm’s Z Plus Broad Spectrum SPF 45 daily for protection and prevention. AVOID
SUN EXPOSURE DURING AND AFTER TREATMENT
» » » Skin exfoliation (such as using a natural louffa or brush in the shower/bath) prior helps prepare skin for penetration of active
ingredients (see best skin treatment partners below).
Treatment Partner—Best Used With:
To speed up skin lightening results best to combine with Scinderm’s Brightening Weekly Pads.
Use Brightening Weekly pads 1 –3 three times weekly at night , to help speed up results by exfoliating the dead skin cells. This product
helps to push the pigmentation “UP and OUT” by assisting in speeding up the skin cell turnover rate.
SKIN TIP: For faster results, add a few drops of White Lightening Concentrate

How supplied:
Contact: 076 937 6388 or info@scinderm.co.za www.scinderm.co.za

Source: http://renuderm.co.za/wp/wp-content/uploads/2014/01/ALL-BRIGHT-AND-EVEN-PRESCRIBING-INFORMATION-SHEET.pdf

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