JOSHUA REINEKE, Ph.D. Education Doctor of Philosophy in Medical Science at Brown University. Dissertation work was done in the Artificial Organs, Biomaterials and Cellular Technologies Laboratory within the Department of Molecular Pharmacology, Physiology and Biotechnology.
Thesis Title: Mechanisms of intestinal microsphere uptake and quantitative analysis of organ distribution for applications of oral gene, protein and hydrophobic drug delivery.
Bachelor of Science in Biophysics – Received from Brown
Bachelor of Arts in History – Received from Brown
Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program Young Investigator Award
Oliver Cromwell Gorton Arnold Biological Fellow
American Association for the Advancement of Science (AAAS) annual meeting poster presentation Honorary Mention, Denver, Colorado.
Brown University Graduate Fellowship Research Award.
Brown University Undergraduate/Teacher Research Assistance (UTRA) recipient.
Brown University Royce Family Scholarship.
Scientist I, Bio-Tree Systems, Inc., Providence, RI. Co-developed scientific plan and technology and performed small animal surgery, cell culture techniques, tissue cast and digestion and micro-vasculature imaging.
Consultant, Proctor & Gamble Pharmaceuticals, Asacol® brand, Mason, Ohio.
Consulted on ideas for brand promotion, improvement of brand image, served as patient spokesman and legislative advocate for increased funding in IBD research.
Professional Triathlete Top ten national ranking and member of World Championship Team USA (Cornerbrook 2006). Sponsors included Chili’s Grill & Bar Restaurant, Proctor & Gamble Pharmaceuticals, and Providence Bicycle.
Consultant on various projects in the areas of cell encapsulation, immunoisolation, cytokine encapsulation, population studies, and tattoo formulation. Work was performed at/for the following institutions and corporations: University of Kentucky – Louisville, LCT BioPharma, Inc., Freedom 2, Inc., University of Michigan, State University of New York - Buffalo, Spherics, Inc., Neurotech USA, and Fox Chase Cancer Center.
• American Association for the Advancement of Science (AAAS) • American Association of Pharmaceutical Scientists (AAPS) • Controlled Release Society (CRS) • Society of Toxicology (SOT) – Membership pending • Lilly Conferences of College and University Teaching
• USSN # FRL 100/101 095184/2 Nanoparticles with High Uniform Loading of Dye,
• USSN # 60/682,213 Drug Delivery Formulations for Targeted Delivery, Filed 17 May
1. Reineke, J., Ed. “Methods in Molecular Biology: Nanotoxicity,” Humana Press, Springer
2. “Nanotechnology-Based Biomarker Detection,” Reineke, J. in Biomarkers in Drug
Development: A Handbook of Practice, Application, and Strategy, M. Bleavins, R.
Rahbari, M. Jurima-Romet and C. Carini, Eds.; John Wiley and Sons, Inc., Chap. 9, in
3. M Sabel, A Arora, G Su, K Griffith, E Mathiowitz, J Reineke, and A Chang, Generation of a Tumor-Specific Systemic Response After Intratumoral Injection of IL-12 and IL-18 Loaded Poly Lactic Acid Microspheres. Journal of Immunotherapy. Volume 30, 2007: 808-816.
4. M Sabel, A Arora, G Su, E Mathiowitz, J Reineke, and A Chang, Synergistic Effect of Intratumoral IL-12 and TNF-α Microspheres: Systemic Anti-Tumor Immunity is Mediated by the Induction of a CD8+ CTL Response. Surgery. Volume 142, 2007: 749-760.
5. A Arora, G Su, E Mathiowitz, J Reineke, A Chang and M Sabel, Neoadjuvant Intratumoral Ctytokine-Loaded Microspheres are Superior to Post-Operative Autologous Cellular Vaccines in Generating Systemic Anti-Tumor Immunity. Journal of Surgical Oncology. Volume 94, Number 5, 2006; 403-412.
6. L Broderick, S Yokota, J Reineke, E Mathiowitz, C Stewart, M Barcos, R Kelleher and
R Bankert, Human CD4+ Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts are Activated by Local Delivery of IL-12 to Proliferate, Produce INF-γ, and Eradicate Tumor Cells. Journal of Immunology. Volume 174, 2005; 898-906.
7. C Thanos, Z Liu, J Reineke, E Edwards and E Mathiowitz, Improving Relative Bioavailability of Dicumarol by Reducing Particle Size and Adding the Adhesive Poly (Fumaric–co-Sebacic) Anhydride. Pharmaceutical Research. Volume 20, Number 7, July 2003; 1093-1100.
8. C Thanos, Z Liu, M Goddard, J Reineke, N Bailey, M Cross, R Burrill and E
Mathiowitz, Enhancing the Oral Bioavailability of the Poorly Soluble Drug Dicumarol with a Bioadhesive Polymer. Journal of Pharmaceutical Sciences. Volume 92, Issue 8, May 2003; 1677-89.
1. J Reineke, Drug Targeting with Ease: Internalization and Organ Fate of Nanoparticles.
Department of Biomedical Engineering Seminar Series, Wayne State University, Detroit, Michigan, September 2009
2. A Mohammed and J Reineke, Pulmonary Nanoparticle Internalization and Transit Pathways. Controlled Release Society Annual Meeting, Copenhagen, Denmark 2009.
3. J Reineke, D Cho, P Cheifetz, Y Liu and E Mathiowitz, Bioadhesion of Microspheres Correlates with In Vivo Intestinal Uptake. Controlled Release Society Annual Meeting, Copenhagen, Denmark 2009.
4. J Reineke, A Morello, Y Liu, D Cho and E Mathiowitz, Microsphere Uptake Kinetics and Biodistribution from Isolated Intestinal Regions. Controlled Release Society Annual Meeting, Copenhagen, Denmark 2009.
5. J Reineke, Mechanisms of Nanoparticle Internalization and Resulting Organ Fate.
Department of Immunology and Microbiology Seminar Series, School of Medicine, Wayne State University, Detroit, Michigan, February 2009.
6. J Reineke, Passive Nanoparticle Targeting from the Lung, Nano@Wayne Brown Bag
Series, Wayne State University, Detroit, Michigan, February 2009.
7. J Reineke, Mechanisms of Nanoparticle Internalization and Resulting Organ Fate.
Department of Chemical Engineering Seminar Series, Wayne State University, Detroit, Michigan, October 2008.
8. J Reineke, Intestinal Uptake Mechanisms and Organ Fate of Microsphere Drug Delivery Systems. Department of Pharmaceutical Sciences Seminar Series, Wayne State University, Detroit, Michigan, November 2007.
9. J Reineke and Jennifer Lewton, Individual Teaching Consultations: Who are they for and what you can gain. Workshop Leader, Sheridan Center for Teaching and Learning 25th Anniversary Symposium, Providence, Rhode Island 2007.
10. N Thompson, J Reineke, M Waring, T Cronin Entering Mentoring – Training for trainees on how to become effective mentors. Podium Presentation, Association of American Medical Colleges – Graduate Research, Education, and Teaching Group Meeting, Providence, Rhode Island 2007.
11. E Mathiowitz, A Morello, B Laulitch, H Qian, J Reineke, M Harrison, P Cheifitz, S
Furtado, R Burrill, Advances in Peptide and Protein Delivery. Invited Speaker, Controlled Release Society Annual Meeting, Long Beach, California 2007.
12. J Reineke, Y Liu and E Mathiowitz, Nanosphere Carriers for Oral Drug Delivery: Measurement of Efficiency, Mechanism, Kinetics and Biodistribution. Brown University Nanomedicine Showcase, Providence, Rhode Island 2006.
13. J Reineke, Y Liu and E Mathiowitz, Quantitative Resident Time Analysis of Microsphere Drug Delivery Systems. Student Poster Session, American Association for the Advancement of Science Annual Meeting, St. Louis, Missouri 2006.
14. J Reineke, A Morello, P Weston, T Ricketts, M Schestopol and E Mathiowitz, Quantitative Biodistribution of Microsphere Drug Delivery Systems: Delivery of Vehicle versus Encapsulated Compound. Nanotechnology Session Podium, Controlled Release Society Annual Meeting, Miami, Florida 2005.
15. S Furtado, R Burrill, J Reineke, A Morello, M Harrison, G Olivier, C Gourd, H Qian and
E Mathiowitz, Oral Delivery of Insulin Microspheres to Type I Diabetic Dogs. Student Poster Session, Controlled Release Society Annual Meeting, Miami, Florida 2005.
16. J Reineke, C Thanos, S Chen and E Mathiowitz, Enhanced Oral Delivery of Hydrophobic Drugs Encapsulated by Poly (Fumaric-co-Sebacic) Anhydride. Student Poster Session, Controlled Release Society Annual Meeting, Honolulu, Hawaii 2004.
17. J Reineke, H Qian and E Mathiowitz, Bioadhesive Poly (Fumaric-co-Sebacic) Acid Copolymers for Improved Bioavailability. Student Poster Session, American Association for the Advancement of Science Annual Meeting, Denver, Colorado 2003.
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This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formattedPDF and full text (HTML) versions will be made available soon. The role of emergency surgery in hydatid liver disease World Journal of Emergency Surgery 2014, 9 :12 Article type Submission date Acceptance date Publication date Article URL This peer-reviewed article can be download