premature closure of ductus arteriosus, therefore, it should not be used in the third trimester of pregnancy, it should alsobe kept in mind that inhibition of prostaglandin synthesis can also cause increase in delivery time.
Nursing Mothers: Xoxilum (meloxicam) has been shown to
be excreted in milk of lactating rats. Therefore the use otXoxilum (meloxicam) should be avoided in lactating womenor a decision should be made to discontinue nursing.
DESCRIPTION: Xoxilum (meloxicam) is a non-steroidal anti-
Children: The efficacy and safety of Xoxilum (meloxicam)
inflammatory drug (NSAID), which selectively inhibits has not been well studied in patients less than 18 years of cyclooxygenase-2 (Cox-2). It is an oxicam derivative. Xoxilum (meloxicam) has anti-inflammatory, analgesic and antipyretic Elderly: In elderly patients of more than 65 years of age the
administration of Xoxilum (meloxicam) should be carefully INDICATIONS:
Drug Interactions: Xoxilum (meloxicam) can exhibits
The relief of signs and symptoms of acute and • Aspirin: concomitant administration of Xoxilum The relief of signs and symptoms of acute and (meloxicam) can increase adverse effects.
• Lithium: If given with lithium Xoxilum (meloxicam) The relief of signs and symptoms of back pain can reduce renal clearance and increase serum concentration of lithium. Careful monitoring of The treatment of primary dysmenorrhea.
lithium treatment is advised when Xoxilum DOSAGE AND ADMINISTRATION: The usual recommended
• ACE inhibitors: antihypertensive effect of ACE dosage of Xoxilum (meloxicam) is 7.5mg or 15mg once a day. In acute painful conditions with severe pain like rheumatoid administration of Xoxilum (meloxicam).
arthritis the preferred dose is 15mg per day. The usual • Warfarin: anticoagulant effect of Xoxilum (meloxicam) can potentiate the effects of CONTRAINDICATIONS/WARNING:
Side Effects: Xoxilum (meloxicam! is generally well tolerated
Selective Cox 2 inhibitors and some NSAIDs have been as compared to non-selective NSAIDs. Owing to selective shown to have a potential increased risk of cardiovascular inhibition of cyclooxygenase-2 the incidence of gastrointestinal events and potentially life-threatening gastrointestinal bleeding.
side effects is low with Xoxilum (meloxicam).
Xoxilum tablets, therefore, should not be given to patients General: Allergic reaction, anaphylactoid reactions, fatigue,
with acute peptic ulcer, with a history of such ulceration or in malaise, face edema fever, hot flushes.
patients immediately after coronary artery bypass surgery.
Gastrointestinal: Dry mouth, eructation, esophagitis, duodenal
Xoxilum (meloxicam) is contraindicated in patients having ulcer, gastric ulcer, gastritis, gastroesophageal reflux, hypersensitivity to the molecule. It is also contraindicated in gastrointestinal hemorrhage, hematemesis, hemorrhagic gastric ulcer, melena, pancreatiris, stomatitis, colitis.
PRECAUTIONS: Hepatic Effects
Cardiovascular system: Cardiac failure, vasculitis,
Few patients taking Xoxilum (meloxicam) report elevation hypertension, hypotension, arrhythmia, palpitation, tachycardia.
Hematologic: Leukopenia, thrombocytopenia, agranulocytosis,
Rarely the elevation can be more than three-folds the normal values. Jaundice, fulminant hepatitis, hepatic necrosis and Liver: Increase in ALT or AST, bilirubinemia, increased GGT,
hepatic failure are rarely encountered in patients taking Xoxilum Central and Peripheral Nervous System: Tremor, vertigo,
Renal Effects: With pre-existing compromised kidney
functions, it is advised to be cautious while using NSAIDs Psychiatric Disorders: Anxiety, increased appetite,
including Xoxilum (meloxicam). Physiological renal blood flow somnolence, confusion, depression, nervousness.
is dependent upon normal synthesis of prostaglandins.
R e s p i r a t o r y S y s t e m : A s t h m a , b r o n c h o s p a s m .
Interference of prostaglandins synthesis can cause renal Skin and Appendages: Urticaria, pruritus, angioedema,
decompensation. Heart failure, dehydration and use of diuretics bullous eruption, alopecia, photosensivtiy reaction, Stevens- make patients more prone to such side effects.
Johnson syndrome, erythema multiforme, increased sweating, Special Population
Hepatic Insufficiency: In case of mild to moderate hepatic
Urinary System: Albuminuria, hematuria, increased BUN,
insufficiency dose adjustment of Xoxilum (meloxicam) is not increased serum creatinine. renal failure.
needed. There is not enough data on the pharmacokinetics Presentation:
Xoxilum 7.5mg Tablets: Each tablet contains meloxicam 7.5mg Renal Insufficiency: In patients having creatinine clearance
of more than 15ml/min. there is no need to bring about Xoxilum 15mg Tablets: Each tablet contains meloxicam 15mg adjustment of dose of Xoxilum (meloxicam). In severe renal failure, however, enough studies have not been conducted
to determine the dose.
Pregnancy (Category C): Because of lack of data in pregnant
women, Xoxilum (meloxicam) should only be used during
pregnancy if benefitsclearly outweigh the risks to fetus and
mother. Like other NSAIDs, Xoxilum (meloxicam) can cause
Manufactured by:
Plot # 154, Sector-23, K.I.A.,
Karachi-74900, Pakistan.


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