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Starkenborglaan 6, 2341 BM, Oegstgeest, The Netherlands Telephone
d.[email protected]
Date of Birth
Marital Status
Elementary School
High School
University Leiden, The Netherlands, 1978-1983 Specializations
Biochemistry, Physical Chemistry, Immunology, During specializations 3 publications, 1 abstract, 1 lecture
Scientific Associate, 10/1/1983 - 12/31/1990 Leiden University Medical Centre, Department of University Leiden, Faculty of Medicine, 1/30/1991, Cum Laude Title Thesis
The role of crystallization processes in calcium oxalate FUNCTIONS
Researcher, 2/20/1991 - 5/1/91 and 12/12/1992 - 6/1/93 Alton Ochsner Medical Foundation, New Orleans, USA NWO-NATO Fellow, 6/1/1991 - 6/1/1992 Center for Mineral Metabolism and Clinical Research, Southwestern Medical Center, University of Texas, Dallas, USA Royal Dutch Academy of Sciences-Fellow, 6/1/1992- 6/1/95 Leiden University Medical Centre, Leiden, The Netherlands. As part of KNAW-Fellowship, Guest Researcher, 12/12/1992 to 6/1/1993, Alton Ochsner Medical Foundation, New Orleans, La, USA 6/1/1993 to 9/31/1993, Dept. of Pathology, Univ. of Florida, Gainesville, USA 7/1/1994 - 8/1/1994, Universitatspoliklinik Inselspital, Bern, Switzerland Lecturer Pediatric urology and stone research, 10/1/95 - present Department of Urology (Recipient of first EUR-fellowship). ErasmusMC, JNI,362b. P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. RESEARCH


Calcification-mechanisms in the algae Emiliania Huxleyi. Structural characterization of the polysaccharide associated with the algeal calcium carbonate mineral, testing of its effects on calcium carbonate crystallization. (publications 1,3,4) Immunology
Isolation and characterization of the C3b complement -receptor from human erythrocytes. Assessment of its role in the human immunologic system. (publication 2) Informational science Dataprocessing, applied statistics, Pascal, SPPS
Urinary stones
Cause and treatment of calcium oxalate urinary stone formation, with a focus on the role of crystallization processes, crystal-cell interaction, renal interstitial reactions, renal develop- ment and treatment in calcium oxalate stone formation. Pediatric Urology
Renal and bladder pathogenesis in obstruction of the urinary tract. Ongoing projects deal with: functional and structural changes in the bladder and kidney with infravesical obstruction and renal effects of ureteral obstruction. In both projects a major focus is development of new diagnostics and interventions. Malignant transformation of early germ cells in ovotestis. The objectives of this project are to improve the treatment of inter- sex patients and to develop early markers for testicular tumors. Urinary tract infection. The role of bacterial populations in the urinary tract for cause and diagnosis of urinary tract infection. Organizations
Dutch Crystal Growth Association, Dutch Chemistry Society, Dutch Polymer Society, Euro-Lithiasis Society, Society for Vlietstra-prize, 2001 Schreinemacher prize 2002 EAU poster award, 2005 Functions
President 9th European Urolithiasis Symposium, Rotterdam Member Editorial Board Urological Research Member advisory board of the Euro-lithiasis Society. Grant proposal consultant for the oxalosis and hyperoxaluria foundation, the National Research Foundations of Hong Kong and of South Africa, the Alton Ochsner Medical Foundation, the Alleheghny Singer Hospital, the University of MANAGEMENT/ TEACHING
Project leader of multiple research projects Organisation of multiple internal conferences, workgroups etc. 1991-1993
Establishment of stone clinic at the Alton Ochsner Medical Foundation, New Orleans. Setting up the laboratory infrastructure, teaching staff, urology/ nephrology fellows and technical assistants 1999-2000
Member consensus meeting on guidelines for the management of 2000-2001
Organisation of the 9th European Urolithiasis Symposium 1984-1990
Tutor of biology and chemistry students at the LUMC. Tutor of multiple "3e en 4e jaars keuzeonderzoekstudenten" and students from the "HLO Etten-Leur". Participation in courses on geobiochemistry University Leiden and Co-ordinator "2e jaars keuzeonderwijs cluster 12". Participation in courses on computer based literature search. PUBLICATIONS
See also detailed list
Peer reviewed journals

Proceedings, abstract
Book editor
Presentations international
National press
National TV
Peer-reviewed journals.
1 Borman AH, de Jong EW, Huizinga M, Kok DJ, Westbroek P, Bosch L. The role in
CaCO3 crystallization of an acid Ca2+ binding polysaccharide associated with
coccoliths of Emiliania Huxleyi. Eur J Biochem 1982; 129: 179-183
2 Daha MR, Kok DJ, van ES LA. Regulation of the C3-nephritic factor stabilized
C3/C5 convertase of complement by purified human erythrocyte C3b receptor.
Clin Exp Immun 1982; 50: 209-214.
3 Westbroek P, de Jong EW, vd Wal P, Borman AH, de Vrind JPM, Kok DJ, de
Bruyn WC, Parker SB. Mechanism of calcification in the marine alga Emiliania
Huxleyi. Phil Trans Roy Soc London B 1984; 304: 435-444.
4 Borman AH, Kok DJ, de Jong EW, Westbroek P, Varkevisser FA, Bloys van Tres-
long CJ, Bosch L. Molar mass determination of the polysaccharide associated with
coccoliths of Emiliania Huxleyi. Eur Polymer J 1986; 22: 521-527.
5 Kok DJ, Blomen LJMJ, Westbroek P, Bijvoet OLM. Polysaccharide from coccoliths
(CaCO3 biomineral). Influence on crystallization of calcium oxalate monohydrate.
Eur J Biochem 1986; 158: 167-172.
6 Kok DJ, Papapoulos SE, Bijvoet OLM. Excessive crystal agglomeration with low
citrate excretion in recurrent stone formers. The Lancet 1986; i: 1056-1058.
7 Kok DJ, Papapoulos SE, Bijvoet OLM. Low inhibition of crystal agglomeration and
citrate excretion in recurrent calcium oxalate stone formers. Contrib to Nephrology
1987; 58: 73-77.
8 Kok DJ, Papapoulos SE, Bijvoet OLM. Modulation of calcium oxalate monohydrate
growth kinetics in vitro. Kidney Int 1988; 34: 346-350.
9 Kok DJ, Papapoulos SE, Bijvoet OLM. Crystal agglomeration is a major element
in calcium oxalate urinary stone formation. Kidney Int 1990; 37: 51-56.
10 Kok DJ, Iestra J, Doorenbos JC, Papapoulos SE. The effects of chronic dietary loads
with salt and animal protein on the calcium oxalate crystallization kinetics in urines
of healthy men. J Clin Endocrin Metab, 1990; 71: 861-867.
11 Kok DJ, Papapoulos SE. Physicochemical considerations in development and preven
tion of calcium oxalate urolithiasis, a review. Bone and Mineral 1993; 20: 1-15.
12 Kok DJ, Poindexter J, Pak CYC. Calculation of titratable acidity. Kidney Int, 1993;
44: 120-126.
13 Kok DJ, Khan SR. Calcium oxalate Nephrolithiasis, a free or fixed particle disease.
Kidney Int, 1994; 46: 847-854.
14 Westbroek P, Buddemeier B, Kok DJ et al. Strategies for the study of climate forcing
by calcification. Bulletin de l'Institute Oceanographique. 1994; 13: 37-60.
15 Erwin DT, Kok DJ, Alam J, Cole FE et al. Predicting Recurrent Renal Stone
formation and Therapy using crystal agglomeration inhibition. Am J Kidney Dis
1994; 24: 893-900.
16 Breslau NA, Padalino P, Kok DJ, Kim YG, Pak CYC. Physicochemical effects of a
new slow-release potassium phosphate preparation (urophos-K) in absorptive hyper-
calciura. J Bone Min Res 1995; 10: 394-400.
17 Fuselier HA, Cole FE, Kok DJ et al. Urinary Tamm-Horsfall Protein increased after
potassium citrate therapy in calcium stone formers. Urology 1995; 45: 942-946.
18 Kok DJ. Free and fixed particle mechanism, a review. Scanning Electron Micros-
copy 1996; 10: 471-486.
19 Kok DJ. Intratubular crystallization events. World J Urol 1997; 15: 219-228.
20 Cao LC, Kok DJ et al. Gags and semisynthetic sulfated polysaccharides: An
overview of their potential application in treatment of patients with uro-
thiasis.Urology 1997; 50: 173-183.
21 De Bruijn WC, Kok DJ et al. Ultrastructural osteopontin localization in papillary stones induced in rats. Eur Urol 1997; 32: 360-367.
22 Fuselier HA, Moore K, Lindberg J, et al.Agglomeration inhibition reflected stone-
forming activity during long-term potassium citrate therapy in calcium stone
formers Urology 1998; 52: 988-994.
23 de Water R, Noordermeer C, Kok DJ et al. Calcium oxalate nephrolithiasis: Effect
of renal crystal deposition on the cellular composition of the renal interstitium. Am
J Kidney Dis
1999; 33: 761-771.
24 Verkoelen CF, Kok DJ, et al. Cell type-specific acquired protection from crystal
adherence by renal tubule cells in culture. Kidney Int 1999; 55: 1426-1433.
25 Verkoelen CF, Kok DJ, van der Boom BG, et al.LLC-PK1 cells as a model system
to study proximal tubule transport of water and other compounds relevant for renal
stone disease. Urol Res 1999; 27: 109-115.
26 Kok DJ, Schell-Feith. Risk factors for crystallization in the nephron: the role of
renal development. J Am Soc Nephrol 1999; 10: S364-370
27 Verkoelen CF, Kok DJ et al. Attachment sites for particles in the urinary tract. J
Am Soc Nephrol
, 1999; 10: S430-435
28 Verkoelen CF, Kok DJ et al. Sialic acid and crystal binding. Kidney Int, 2000; 57:
29 Wolffenbuttel KP, Kok DJ et al. Vanished testis: be aware of an abdominal testis.
J Urol, 2000; 163: 957-958.
30 Kok DJ, Wolffenbuttel KP et al. Changes in bladder contractility and bladder
compliance upon uretrhal obstruction: a longitudinal follow-up of individual
guinea pigs. J Urol, 2000; 164: 1021-1024.
31 Lindberg JS, Cole FE, Romani W, Husserl FE, Fuselier HA, Kok DJ, Erwin DT.
Calcium oxalate stone agglomeration inhibition [tm] reflects renal stone forming
activity. The Oschner Journal 2000; 2: 68-79.
32 Mathoera RB, Kok DJ, Nijman RJ. Bladder calculi in augmentation cystoplasty in
children. Urology 2000; 56; 482-7.
33 R. de Water, C. Noordermeer, A.B. Houtsmuller, D.J. Kok, H. Nizze, F.H.
Schröder. The role of macrophages in Nephrolithiasis in rats: An analysis of the
renal interstitium. Am J Kidney Dis 2000; 36: 615-625.
34 Wolffenbuttel KP, Kok DJ et al. Longitudinal urodynamic follow-up of experi-
mental urethral obstruction in individual guinea pigs. Neurourol Urodynam,
2001; 20 (6): 699-713
35 de Water R, Leenen PJM, Noordermeer C, Nigg AL, Houtsmuller AB, Kok DJ,
Schröder FH. Macrophages in nephrolithiasis: cytokine production induced by bin-
ding and processing of calcium oxalate crystals. Am J Kidney Dis 2001; 38: 331-338
36 Salahuddin S, Hsu YS, Buchholz NP, Dieleman JP, Gyssens IC, Kok DJ. Is Indinavir
crystalluria an indicator for indinavir stone formation? AIDS 2001; 15: 1079-1080
37 Dieleman JP, Salahuddin S, Hsu YS, Burher DM, Gyssens IC, Sturkenboom
MCJM, Stricker BHCh, Kok DJ. Indinavir crystallisation under loop of Henle
conditions: experimental evidence. J Acq Immun Def Synd 2001; 28: 9-13
38 Wolffenbuttel KP, Kok DJ, van Mastrigt R, van den Berg E, Nijman RJM. Mea- surement of urine flow-rate using ultrasound in small boys and male infants. J Urol
2001; 166(3):1058-61.
39 Schell-Feith EA, Que I, Kok DJ, Kist-van Holthe JE, Kühler E, Brand R, Papapoulos SE, vd Heijden BJ. Modulation of calcium oxalate monohydrate
crystallization kinetics by urine of preterm neonates. Am J Kidney Dis, 2001; 38:
40 Hess B, Ryal RL, Kavanagh JP, Khan SR, Kok DJ, Rodgers AL, Tiselius HG. Methods for measuring crystallization in urolithiasis research - why, how and
when? Eur Urol 2001; 40: 220-230
41 Advisory Board European Urolithiasis Research. Possibilities for prevention of
recurrent calcium stone formation. Principles for the metabolic evaluation of
patients with calcium stone disease. BJU int, 2001; 88: 158-168.
42 Mathoera RB, Kok DJ, Visser WJ, Verduin CM, Nijman RJ. Cellular membrane
associated mucins in artificial urine as mediators of crystal adhesion; an in-vitro
enterocystoplasty model. J Urol 2001; 166: 2329-2336
43 Dey J, Creighton A, Lindberg JS, Fuselier HA, Kok DJ, Cole FE. Estrogen re-
placement increased citrate and calcium excretion rates in postmenopausal women
with recurrent urolithiasis. J Urol 2002; 167: 169-171
44 de Jong BWD, Bakker Schut TC, Wolffenbuttel KP, Nijman JM, Kok DJ, Puppels
GJ. Identification of bladder wall layers with Raman spectroscopy. J Urol
45 Kok DJ. Clinical implications of physicochemistry of stone formation. Endocrine
Metab Clin N AM
2002; 31:855-67.
46 Mathoera RB, Kok DJ, Verduin K, Nijman RJM. Pathological and therapeutical
significance of cellular invasion by Proteus Mirabilis in an enterocystoplasty
infection stone model. Infect Immun 2002; 70: 7022-7032.
47 Turan T, v Harten JG, de Water R, Tuncay OL, Kok DJ. Is enalapril adequate for
the prevention of renal tissue damage caused by unilateral obstruction and/or
hyperoxaluria? Urol Res, 2003 31: 212-217.
48 De Jong BWD, de Gouveia Brazao CA, Stoop H, Oosterhuis JW, Puppels GJ,
Weber RFA, Looijenga LHJ, Kok DJ.Identification of testicular microlithiasis by
Raman spectroscopy: intratubular located hydroxyapatite. J Urol, 2004, 171: 92-6.
49 de Jong BWD, Bakker-Schut TC, Coppens J, Wolffenbuttel KP, Kok DJ, Puppels
GJ. Characterization of collagen infiltration by Raman spectroscopy. Vibrational
2003,32: 57-65.
50 Khan SR, Kok DJ. Modulators of urinary stone formation. Front Bioscience2004,
1;9: 1450-82
51 de Jong BWD, Bakker Schut TC, Maquelin K, van der Kwast Th, BangmaCH,
Kok DJ, Puppels GJ . Discrimination between non-tumor bladder tissue and tumor
By Raman spectroscopy. Anal Chem 2006;78: 7761-9.
52 Wolffenbuttel KP, Wondergem N, Hoefnagels JJS, Dieleman GC, Passchier
BTWD, de Jong BWD, van Dijk W, Kok DJ. Abnormal urine flow in boys with
distal hypospadias before and after correction. J Urol, 2006; 176: 1733-6.
53 Salahuddin S, Kok DJ, Buchholz NN. Influence of body temperature on indinavir crystallization under loop of Henle conditions. J Antimicrob
. 2007; Jan; 59: 114-7. Epub 2006 Nov 9.
54 Scheepe JR, de Jong BWD, Wolffenbuttel KP, Arentshorst ME, Lodder P, Kok DJ. The Effect of Oxybutynin on Structural Changes of the Obstructed Guinea
Pig Bladder. J Urol 2007; 178: 1807-1812
55 de Jong BW, Wolffenbuttel KP, Arentshorst ME, Lodder P, Kok DJ.Detrusor glycogen reflects the functional history of bladders with partial outlet
obstruction. BJU Int. 2007; 100: 846-52.
56 Kummeling MTM, de Jong BWD, Laffeber C, Kok DJ, Verhagen PCMS, van Leenders GJLH, van Schaik RHN, van Woerden CS, Verhulst A, Verkoelen
CF. Tubular and interstitial nephrocalcinosis. J Urol 2007; 178: 1097-1103
57 Wolffenbuttel KP, de Jong BW, Scheepe JR, Kok DJ.Potential for recovery in bladder function after removing a urethral obstruction. Neurourol Urodyn.
2008 June 12.
58 de Jong BW, Wolffenbuttel KP, Scheepe JR, Kok DJ.The detrusor glycogen content of a de-obstructed bladder reflects the functional history of that bladder
during PBOO. Neurourol Urodyn. 2008; 27: 454-60.
59 de Jong BW, Scheepe JR, Wolffenbuttel KP, et al.Ischemia in the bladder upon outlet obstruction: The role of voiding pressure, contractility, detrusor
overactivity and compliance. J Urol 2008; 179: 221
60 van der Wielen GJ, Vermeij M, de Jong BWD, Schuit M, Marijnissen JPA, Kok DJ, van Weerden WM, Incrocci L. Changes in the penile arteries of the rat after
fractionated irradiation of the prostate: a pilot study. J Sex Med 2009;
Book (chapter)s B1 Kok DJ. The role of crystallization processes in calcium oxalate urolithiasis. Thesis, Leiden 30-1-1991. B2 Hess B, Kok DJ. Nucleation, Growth and aggregation of stone forming crystals. In: Kidney stones: Medical and surgical management. Coe FL, Favus M, Pak CYC, Parks J and Preminger G. (eds.) Lippincott-Raven. Philidelphia. 1996; Chapter 1; 3-32. ISBN 0-7817-0263-1 B3 Kok DJ. Inhibitors of calcium oxalate Calcium oxalate in biological systems. Editor Khan SR, CRC press of Boca Raton, Fl USA. 1995, chapter 2, pp 23-36. B4 EUROLITHIASIS. editors: DJ Kok, HC Romijn, PCMS Verhagen, CF Verkoelen. Shaker Verlag, Maastricht 2001. ISBN 90-423-0171-6 B5 Khan SR, Kok DJ. Modulators of crystallization of stone salts. In: Current clinical urology, Urinary Stone disease, a practical guide to medical and surgical management. Eds. M.L. Stoller, M.V. Meng. Humana press Inc, Totowa, NJ, 2007. chapter 10 B6 Kok DJ. Crystallisation and other studies. In: Urinary Tract Stone Disease. Eds. Nagaraja Rao, John Kavanagh & Glenn Preminger. Springer Books 2010, in press


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