Homework 3 Solutions - 90 total pointsSTAT 201-502
1 It is believed that smokers may have a more difficult time quitting smoking if they live with an-
other smoker. How can an experiment explore the effects of Zyban with a placebo on quittingsmoking with subjects in different living situations? Suppose the researchers split the subjetsinto two groups: those who live with another smoker and those who do not live with smok-ers. Within each group, the subjects are randomly assigned to take Zyban or a placebo. Inthis study 250 of the 429 study subjects live with nonsmokers and 179 live with another smoker.
a. What are the explanatory and response variables?
The explanatory variable is medicine and the response variable is success in quitting smok-ing.
They divide the subjects into groups first: “those who live with another smoker and thosewho do not live with smokers”. The blocking factor is smoking living situation.
c. How many factors are there? How many levels for each factor?
The factor is medicine with two levels: Zyban or placebo(no Zyban).
d. Draw a diagram of the experiment design.
2 Do textbook problems 3.4, 3.25, 3.37, 3.47a, 3.81, 3.84, 3.92
3.4:(a) This is an observational study because no treatment is imposed on the subjects (children);they (or their parents) choose how much TV they watch. The explanatory variable i hourswatching TV and the response variable is “later agressive behavior”.
(b) A child who watches a lot of television is probably more likely to spend less time doinghomework, playing sports, or having social interactions with peers. He or she may also have lesscontact with or guidance from his/her parents.
(a)”Randomized” = patients were randomly assigned the treatment (to recieve St-John’s-wort orplacebo), ”double-blind” = treatment assigned to subject was unknown by doctors, administra-tors or subjects, ”placebo-controlled” = one treatment was a placebo used to show phycologicaleffect of taking any medicine(b)
3.37:(a)population = adults age 18+ in the US, sample size = 1002(b)Perhaps people are more inclined to respond with the first or last option they hear becauseit is what they remember best. Rotating the order of the options would cancel out any effect onthe response of such inclinations.
(a)We divide the population of 9,000 into 200 groups where we will choose 1 person from eachgroup randomly. 9 000
= 45 people in each group. So choose 1 person from the first group at
random using Table B and then choose every 45th person from there.
(a)matched-pairs design(b)sample survey with a stratified sample: smokers and non-smokers(c)randomized experiment with block on gender
(a)sample survey(b)experiment(c)observational study
3.92 Use a block design: Separate men and women, and randomly allocate each gender amongthe six treatments.
Journal of Antimicrobial Chemotherapy (2009) 63, 389 – 395doi:10.1093/jac/dkn489Advance Access publication 28 November 2008Cranberry or trimethoprim for the prevention of recurrent urinarytract infections? A randomized controlled trial in older womenMarion E. T. McMurdo1*, Ishbel Argo1, Gabby Phillips2, Fergus Daly3 and Peter Davey31Ageing and Health, Division of Medicine and Therapeutics,
Yorkshire and the Humber Specialised Commissionning Group Board Meeting - 24th September 2010 Decision Summary for PCT Boards 1. Policies: General Commissioning Policies for Medicines and Treatments The following four policies were approved for adoption by the SCG:- Imatinib for the adjuvant treatment of gastrointestinal stromal tumours - To be not routinely funde