Blastocystis hominis and Dientamoeba fragilis
Two common parasites often present include Blastocystis hominis and Dientamoeba fragilis of which little is known.
It is suspected that they spread between humans by faecal-oral. Apart from the usual gastrointestinal symptoms such as abdominal pain, bloating, diarrhoea and flatulence they can also produce fatigue. Studies have linked their presence to chronic fatigue syndrome. Many studies are now confirming the gut-brain link which suggests digestive problems may be responsible for emotional and mental imbalances.
Blastocystis hominis can be extremely resistant to treatment, and like D.fragilis readily survives Flagyl. Despite the
high failure rate of this drug it continues to be the drug of choice for many doctors. Thankful y the work performed at an Australian gastroenterology clinic, The Centre for Digestive Diseases, who specialise in the treatment of these parasites have developed an effective combination of drugs to treat these parasites with a success rate of around 82%.
Treatment Protocol includes:
Nitazoxinide 500mg 20 Caps– 1 Capsule morning and night for 10 daysSecnidazole 400mg 30 Caps – 1 Capsule three times a day for 10 daysFurazolidone 100mg 30 Caps – 1 Capsule three times a day for 10 days
The anti-parasitic drugs above are available through us and require a private (non-PBS) script from your doctor according to the instructions above.
(2) Blastocystis and D. Fragilis combined
Nitazoxinide 500mg 20 Caps– 1 Capsule morning and night for 10 daysSecnidazole 400mg 30 Caps – 1 Capsule three times a day for 10 daysFurazolidone 100mg 30 Caps – 1 Capsule three times a day for 10 daysDoxycycline 50mg 20 Caps – 1 Capsule morning and night for 10 days
The anti-parasitic drugs above are available through us and require a private (non-PBS) script from your doctor according to the instructions above. Doxycycline is available from any retail pharmacy. Stemetil may also be prescribed for nausea whilst on this treatment.
Due to the resistance of these parasites you cannot assume that the treatment was successful. Therefore it is essential that the patient is re-tested 4 weeks or so after the treatment.
If this treatment fails the clinic suggests:
Septrin DS – 1 tablet morning and night for 10 days. (NB: Use Noroxin 400mg twice a day if al ergic to Sulphur drugs) Tetracycline HCl 500mg – 1 Capsule three times a day for 10 daysNitazoxanide 500mg – 1 Capsule three times a day for 10 days
We recommend that the stool analysis be performed by Metametrix specialist pathologists as they are the only laboratory we are aware of that uses DNA analysis to identify microbiota which is far more accurate and sensitive (5000 fold) compared to old stool technology used by most other labs. This type of testing is stil not routinely used by most pathologists and is the major cause of many false negative results. Parasites rapidly breakdown once they leave the body. This breakdown changes the structure (morphology) of the parasite and thus makes identification very difficult using old techniques. By measuring the presence of their DNA greatly increases the parasite being correctly identified even if it has already broken down.
The Centre for Digestive Diseases 144 Great North Rd, Five Dock, Sydney. Ph: 02 97134011 Prof. Tom Borody is the clinic director however contact Sister Sharyn Leis for advice. Metametrix PO Box 904, Crown Nest, Sydney Ph: 02 99669990
FINAL SCIENTIFIC PROGRAM THURSDAY, JUNE 08, 2006 12.00-15.00 Registration 14.00 SCUR Board members meeting/coffee, tea and sandwiches 14.45-15.00 Opening 15.00-15.30 INVITED LECTURE Chairman: S. Jablonska Slawomir Majewski (Warszawa, Poland) A possible role of epidermodysplasia verruciformis-associated human papillomaviruses in the pathogenesis of psoriasis. 15.30-16.30 FREE COM
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